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58 papers found.
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Exploratory analysis of protein translation regulatory networks using hierarchical random graphs

=S3. Authors contributions DDW designed the study, performed the computational experiments, and drafted the manuscript. XH supervised the study. E.K. Park, Xiaofeng Wang, Jiali Feng, and Xindong Wu

A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65)

Background Human glutamic acid decarboxylase 65 (hGAD65) is a key autoantigen in type 1 diabetes, having much potential as an important marker for the prediction and diagnosis of type 1 diabetes, and for the development of novel antigen-specific therapies for the treatment of type 1 diabetes. However, recombinant production of hGAD65 using conventional bacterial or mammalian cell...

A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population

Background To investigate whether genetic variants of the HBV receptor gene NTCP are associated with HBV infection in the Han Chinese population. Methods We sequenced the entire 23 kb NTCP gene from 111 HBeAg-positive HBsAg carriers (PSE group), 110 HBeAg-negative HBsAg carriers (PS group), and 110 control subjects. Then, we performed association analyses of suggestively...

Prevalence and risk factors of gastroesophageal reflux symptoms in a Chinese retiree cohort

Background Data about prevalence of gastroesophageal reflux diseases (GERD) from Asian populations are still scarce. To provide additional data on prevalence of GERD and investigate its potential risk factors, we performed this cross-sectional study in the Taizhou Retiree Cohort. Methods After physical examination, the participants were asked whether they suffered with heartburn...

Predicting gene function using few positive examples and unlabeled ones

& Computational Biology (BioComp 2009). The full contents of the supplement are available online at http://www. biomedcentral.com/1471-2164/11?issue=S2. Authors contributions Zhoujun Li, Xiaofeng ... Wang and Jiali Feng conceived this research and applied project. Xiaohua Hu put forward some suggestion about two algorithms and revised the manuscript. Yiming Chen designed and coded algorithms, wrote

Construction of an integrated genetic linkage map for the A genome of Brassica napus using SSR markers derived from sequenced BACs in B. rapa

Background The Multinational Brassica rapa Genome Sequencing Project (BrGSP) has developed valuable genomic resources, including BAC libraries, BAC-end sequences, genetic and physical maps, and seed BAC sequences for Brassica rapa. An integrated linkage map between the amphidiploid B. napus and diploid B. rapa will facilitate the rapid transfer of these valuable resources from B...

Protecting genomic data analytics in the cloud: state of the art and opportunities

The outsourcing of genomic data into public cloud computing settings raises concerns over privacy and security. Significant advancements in secure computation methods have emerged over the past several years, but such techniques need to be rigorously evaluated for their ability to support the analysis of human genomic data in an efficient and cost-effective manner. With respect...

A community assessment of privacy preserving techniques for human genomes

To answer the need for the rigorous protection of biomedical data, we organized the Critical Assessment of Data Privacy and Protection initiative as a community effort to evaluate privacy-preserving dissemination techniques for biomedical data. We focused on the challenge of sharing aggregate human genomic data (e.g., allele frequencies) in a way that preserves the privacy of the...

Rationales, design and recruitment of the Taizhou Longitudinal Study

Background Rapid economic growth in China in the past decades has been accompanied by dramatic changes in lifestyle and environmental exposures. The burdens of non-communicable diseases, such as cardiovascular diseases, diabetes and cancer, have also increased substantially. Methods/design We initiated a large prospective cohort–the Taizhou Longitudinal Study–in Taizhou (a medium...

Biodetoxification of toxins generated from lignocellulose pretreatment using a newly isolated fungus, Amorphotheca resinae ZN1, and the consequent ethanol fermentation

Background Degradation of the toxic compounds generated in the harsh pretreatment of lignocellulose is an inevitable step in reducing the toxin level for conducting practical enzymatic hydrolysis and ethanol fermentation processes. Various detoxification methods have been tried and many negative outcomes were found using these methods, such as the massive freshwater usage and...

A study of laparoscopic extraperitoneal sigmoid colostomy after abdomino-perineal resection for rectal cancer

Objective: To established a procedure for laparoscopic extraperitoneal ostomy after abdomino-perineal resection (APR) and study safety aspects and complications.

A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia

Gain-of-function mutations in fibroblast growth factor receptor-3 (FGFR3) lead to several types of human skeletal dysplasia syndromes including achondroplasia, hypochondroplasia and thanatophoric dysplasia (TD). Currently, there are no effective treatments for these skeletal dysplasia diseases. In this study, we screened, using FGFR3 as a bait, a random 12-peptide phage library...

Analysis of Charge Redistribution During Self-discharge of Double-Layer Supercapacitors

Self-discharge is an important factor that severely affects the performance of double-layer supercapacitors. This paper studies the self-discharge behavior of double-layer supercapacitors with experimental and modeling methods. The movement of ions, side-reactions, and instability of the double layer are taken into consideration. The influence of various factors, such as the...

Involvement of reactive oxygen species in endosperm cap weakening and embryo elongation growth during lettuce seed germination

Endosperm cap (CAP) weakening and embryo elongation growth are prerequisites for the completion of lettuce seed germination. Although it has been proposed that the cell wall loosening underlying these processes results from an enzymatic mechanism, it is still unclear which enzymes are involved. Here it is shown that reactive oxygen species (ROS), which are non-enzymatic factors...

Bmi-1 regulates stem cell-like properties of gastric cancer cells via modulating miRNAs

Background B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) plays an important role in regulating stemness in some kinds of cancer. However, the mechanisms remain unclear. This study was to investigate whether and how Bmi-1 regulates stemness of gastric cancer. Methods We firstly explored the role of Bmi-1 in regulating stem cell-like features in gastric...

Association of the angiotensinogen M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillation

Purpose: Previous studies showed that genetic variants of the angiotensinogen (AGT) gene conferred higher risk for acquired atrial fibrillation (AF). The present study investigated whether AGT variants correlate with the clinical outcome in patients with acquired AF after catheter ablation (CA).

Apolipoprotein E gene polymorphism and the risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies

Background Studies investigating the association between the apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. Methods Published literature from the...

mtDNA Lineage Expansions in Sherpa Population Suggest Adaptive Evolution in Tibetan Highlands

Sherpa population is an ethnic group living in south mountainside of Himalayas for hundreds of years. They are famous as extraordinary mountaineers and guides, considered as a good example for successful adaptation to low oxygen environment in Tibetan highlands. Mitochondrial DNA (mtDNA) variations might be important in the highland adaption given its role in coding core subunits...

Berkeley Supernova Ia Program – I. Observations, data reduction and spectroscopic sample of 582 low-redshift Type Ia supernovae

Sung Park Daniel A. Perley Dovi Poznanski Cassie A. Reuter James Scala Franklin J. D. Serduke Joseph C. Shields Brandon J. Swift John L. Tonry Schuyler D. Van Dyk Xiaofeng Wang Diane S. Wong 0 Marc J