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64 papers found.
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Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway

Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway Xiaofeng Zhu,1,* Ronghua Zhu2,* 1Department of ... OncoTargets and Therapy curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of mir-145 and inhibition of the Pi3K/akt/mTOr pathway Xiaofeng Zhu 1 0

The cold tolerance of the northern root-knot nematode, Meloidogyne hapla

: Xiaojing Wu, Xiaofeng Zhu. Funding acquisition: Lijie Chen. Investigation: Xiaojing Wu. Methodology: Xiaojing Wu. Project administration: Xiaofeng Zhu, Yuanyuan Wang, Xiaoyu Liu, Lijie Chen, Yuxi Duan ... . Resources: Xiaojing Wu. Software: Xiaojing Wu, Xiaofeng Zhu, Yuanyuan Wang, Xiaoyu Liu. Supervision: Lijie Chen, Yuxi Duan. Validation: Xiaojing Wu, Yuxi Duan. Visualization: Xiaojing Wu, Xiaofeng Zhu

The similarities between smDCs and regDCs in alleviating the immune injury caused by transplantation of hepatocytes differentiated from ESCs

Background This study aimed to investigate the tolerogenic mechanisms induced by semimature dendritic cells (smDCs) and regulatory dendritic cells (regDCs) after transplantation of hepatocytes differentiated from mouse embryonic stem cells (ESCs) and to confirm the low immunogenicity of hepatocytes differentiated from ESCs. Methods Green fluorescent protein-labeled ESCs collected...

Active immunization in patients transplanted for hepatitis B virus related liver diseases: A prospective study

He. Investigation: Zhiyong Guo. Methodology: Zhiyong Guo, Anbin Hu. Project administration: Anli Yang, Zhiyong Guo, Qingqi Ren, Haidan Ye. Resources: Anbin Hu, Xiaofeng Zhu. Software: Dongping ... Wang. Validation: Qingqi Ren. Visualization: Qingqi Ren. Writing ± original draft: Anli Yang. Supervision: Zhiyong Guo, Linwei Wu, Dongping Wang, Xiaofeng Zhu. Writing ± review & editing: Anli Yang

Learning high-dimensional multimedia data

The internet revolution has made information acquisition easy and cheap and has been producing massive high-dimensional multimedia data, including text, audio, images, animation, video, etc. High-dimensional multimedia data bring new opportunities to modern society and challenges to researchers of the multimedia domain as well. The goal of this special issue is bridging the gap...

Management of the soybean cyst nematode Heterodera glycines with combinations of different rhizobacterial strains on soybean

suggestions on the manuscript. 12 / 14 Author Contributions Conceptualization: Xiaofeng Zhu, Xiaoyu Liu, Yuxi Duan. Data curation: Yuanyuan Zhou, Yuanyuan Wang, Xiaofeng Zhu. Formal analysis: Yuanyuan Zhou ... Wang, Xiaofeng Zhu. Writing ± original draft: Yuanyuan Zhou. Writing ± review & editing: Yuxi Duan, Lijie Chen. 13 / 14 1. Duan Y , Chen L , Liu G , Li H , Wang X , Wang Y , etal. Plant pathogenic

Head Injury as a Risk Factor for Dementia and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of 32 Observational Studies

Background Head injury is reported to be associated with increased risks of dementia and Alzheimer’s disease (AD) in many but not all the epidemiological studies. We conducted a systematic review and meta-analysis to estimate the relative effect of head injury on dementia and AD risks. Methods Relevant cohort and case-control studies published between Jan 1, 1990, and Mar 31...

De novo mutations discovered in 8 Mexican American families through whole genome sequencing

De novo mutations enrich the sequence diversity and carry the clue of evolutional selection. Recent studies suggest the de novo mutations could be one of the risk factors for complex diseases. We conducted a survey of de novo mutations using the whole genome sequence data but only available on the odd autosomes of Mexican American families provided by Genetic Analysis Workshop 18...

Whole genome sequencing data from pedigrees suggests linkage disequilibrium among rare variants created by population admixture

Next-generation sequencing technologies have been designed to discover rare and de novo variants and are an important tool for identifying rare disease variants. Many statistical methods have been developed to test, using next-generation sequencing data, for rare variants that are associated with a trait. However, many of these methods make assumptions that rare variants are in...

Multivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT Consortium

Meta-analysis of single trait for multiple cohorts has been used for increasing statistical power in genome-wide association studies (GWASs). Although hundreds of variants have been identified by GWAS, these variants only explain a small fraction of phenotypic variation. Cross-phenotype association analysis (CPASSOC) can further improve statistical power by searching for variants...

Disparities between Ophthalmologists and Patients in Estimating Quality of Life Associated with Diabetic Retinopathy

Background This study aimed to evaluate and compare the utility values associated with diabetic retinopathy (DR) in a sample of Chinese patients and ophthalmologists. Methods Utility values were evaluated by both the time trade-off (TTO) and rating scale (RS) methods for 109 eligible patients with DR and 2 experienced ophthalmologists. Patients were stratified by Snellen best...

Genomic regions associated with susceptibility to Barrett’s esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study

, Amitabh Chak. Formal analysis: Xiangqing Sun, Kishore Guda, Xiaofeng Zhu, Robert Elston, Amitabh Chak. Funding acquisition: Amitabh Chak. Investigation: Xiangqing Sun, Martina Veigl, Alexander Miron ... , Amitabh Chak. Methodology: Xiangqing Sun, Martina Veigl, Alexander Miron, Joseph Willis, Deepa T. Patil, Kishore Guda, Sanford D. Markowitz, Xiaofeng Zhu, Amitabh Chak. Project administration: Apoorva K

Corneal Thickness Profile and Associations in Chinese Children Aged 7 to 15 Years Old

Corneal thickness (CT) maps of the central (2-mm diameter), para-central (2 to 5-mm diameter), peripheral (5 to 6-mm diameter), and minimum (5-mm diameter) cornea were measured in normal Chinese school children aged 7 to 15 years old using Fourier-domain optical coherence tomography. Multiple regression analyses were performed to explore the effect of associated factors [age...

Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling

Gallbladder carcinoma is an aggressive malignancy with high mortality mainly due to the limited potential for curative resection and its resistance to chemotherapeutic agents. Here, we show that the histone deacetylase inhibitors (HDACIs) trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA) reduce the proliferation and induce apoptosis of gallbladder carcinoma cells by...

Target dose conversion modeling from pencil beam (PB) to Monte Carlo (MC) for lung SBRT

Background A challenge preventing routine clinical implementation of Monte Carlo (MC)-based lung SBRT is the difficulty of reinterpreting historical outcome data calculated with inaccurate dose algorithms, because the target dose was found to decrease to varying degrees when recalculated with MC. The large variability was previously found to be affected by factors such as tumour...

Rare variant density across the genome and across populations

heterogeneity across different populations. Acknowledgments This study was born out of the stimulating discussions held with Robert Elston and Xiaofeng Zhu and their colleagues in the Department of Epidemiology

Updated sesame genome assembly and fine mapping of plant height and seed coat color QTLs using a new high-density genetic map

Background Sesame is an important high-quality oil seed crop. The sesame genome was de novo sequenced and assembled in 2014 (version 1.0); however, the number of anchored pseudomolecules was higher than the chromosome number (2n = 2x = 26) due to the lack of a high-density genetic map with 13 linkage groups. Results We resequenced a permanent population consisting of 430...

Determinants of hypertension in a young adult Ugandan population in epidemiological transition—the MEPI-CVD survey

Background High blood pressure is the principal risk factor for stroke, heart failure and kidney failure in the young population in Africa. Control of hypertension is associated with a larger reduction in morbidity and mortality in younger populations compared with the elderly; however, blood pressure control efforts in the young are hampered by scarcity of data on prevalence and...

A variance component based multi-marker association test using family and unrelated data

Background Incorporating family data in genetic association studies has become increasingly appreciated, especially for its potential value in testing rare variants. We introduce here a variance-component based association test that can test multiple common or rare variants jointly using both family and unrelated samples. Results The proposed approach implemented in our R package...