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17 papers found.
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Is CD47 an innate immune checkpoint for tumor evasion?

Cluster of differentiation 47 (CD47) (also known as integrin-associated protein) is a ubiquitously expressed glycoprotein of the immunoglobulin superfamily that plays a critical role in self-recognition. Various solid and hematologic cancers exploit CD47 expression in order to evade immunological eradication, and its overexpression is clinically correlated with poor prognoses. One ...

Enhanced therapeutic efficacy of LHRHa-targeted brucea javanica oil liposomes for ovarian cancer

Background Although brucea javanica oil liposomes (BJOLs) have been used clinically to treat ovarian cancer, its clinical efficacy is often limited by systemic side effects due to non-specific distribution. Luteinizing hormone releasing hormone receptor (LHRHR) is overexpressed in most ovarian cancers but negligibly expressed in most of the other visceral organs. In this study, we ...

Important role of N108 residue in binding of bovine foamy virus transactivator Tas to viral promoters

Background Bovine foamy virus (BFV) encodes the transactivator BTas, which enhances viral gene transcription by binding to the long terminal repeat promoter and the internal promoter. In this study, we investigated the different replication capacities of two similar BFV full-length DNA clones, pBS-BFV-Y and pBS-BFV-B. Results Here, functional analysis of several chimeric clones ...

Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell type-specific hypomethylation in the regulation of cell identity genes

DNA methylation is a key epigenetic mark that is critical for gene regulation in multicellular eukaryotes. Although various human cell types may have the same genome, these cells have different methylomes. The systematic identification and characterization of methylation marks across cell types are crucial to understand the complex regulatory network for cell fate determination. In ...

BTEB2 Prevents Neuronal Apoptosis via Promoting Bad Phosphorylation in Rat Intracerebral Hemorrhage Model

Krüppel-like zinc-finger transcription factor 5 (KLF5), known as BTEB2 or IKLF, has several biological functions that involve cell proliferation, development and apoptosis. Previous studies demonstrated that BTEB2 had anti-apoptotic effect in multiple diseases such as esophageal cancer and non-small cell lung cancers (NSCLCs). However, the distribution and function of BTEB2 in CNS ...

Dialdehyde starch nanoparticles as antitumor drug delivery system: An in vitro, in vivo, and immunohistological evaluation

Sustaining the release of therapeutic nanoparticles in a cell-, tissue-, or disease-specific manner is a potentially powerful technology. A new drug carrier-dialdehyde starch nanoparticle (DASNP) that can sustain the loading and release of 5-fluorouracil (5-Fu) antitumor drug is reported in this study. IR spectrophotometer and 1H NMR confirmed the formation of aldehyde groups, and ...

Up-Regulation of RACK1 by TGF-β1 Promotes Hepatic Fibrosis in Mice

Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injury, and activation of quiescent hepatic stellate cells (HSCs) into a myofibroblast-like phenotype is considered as the central event of liver fibrosis. RACK1, the receptor for activated C-kinase 1, is a classical scaffold protein implicated in numerous signaling pathways and ...

Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease

Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that sodium phenylbutyrate (NaPB), an FDA-approved therapy for reducing plasma ammonia and glutamine in urea cycle disorders, can suppress both proinflammatory molecules and reactive oxygen species (ROS) in activated glial cells. Interestingly, NaPB also ...

Tree Species Traits but Not Diversity Mitigate Stem Breakage in a Subtropical Forest following a Rare and Extreme Ice Storm

Future climates are likely to include extreme events, which in turn have great impacts on ecological systems. In this study, we investigated possible effects that could mitigate stem breakage caused by a rare and extreme ice storm in a Chinese subtropical forest across a gradient of forest diversity. We used Bayesian modeling to correct stem breakage for tree size and variance ...

Covariation in Plant Functional Traits and Soil Fertility within Two Species-Rich Forests

The distribution of plant species along environmental gradients is expected to be predictable based on organismal function. Plant functional trait research has shown that trait values generally vary predictably along broad-scale climatic and soil gradients. This work has also demonstrated that at any one point along these gradients there is a large amount of interspecific trait ...

QDMR: a quantitative method for identification of differentially methylated regions by entropy

DNA methylation plays critical roles in transcriptional regulation and chromatin remodeling. Differentially methylated regions (DMRs) have important implications for development, aging and diseases. Therefore, genome-wide mapping of DMRs across various temporal and spatial methylomes is important in revealing the impact of epigenetic modifications on heritable phenotypic variation. ...

Smoking and Major Depressive Disorder in Chinese Women

Pan Jicheng Dong Runde Pan Wei Zhang Zhenming Shen Zhengrong Liu Danhua Gu Xiaoping Wang Ying Liu Xiaojuan Liu Qiwen Zhang Yihan Li Yiping Chen Kenneth S. Kendler Xumei Wang Youhui Li Jonathan Flint

Associations of Educational Attainment, Occupation, Social Class and Major Depressive Disorder among Han Chinese Women

Wang Xiaojuan Liu Qiwen Zhang Yihan Li Yiping Chen Kenneth S. Kendler - Background: The prevalence of major depressive disorder (MDD) is higher in those with low levels of educational attainment, the

Childhood Sexual Abuse and the Development of Recurrent Major Depression in Chinese Women

Chen Min Cai Yan Song Jiyang Pan Jicheng Dong Runde Pan Wei Zhang Zhenming Shen Zhengrong Liu Danhua Gu Xiaoping Wang Xiaojuan Liu Qiwen Zhang Yihan Li Yiping Chen Kenneth S. Kendler Shenxun Shi Jonathan

Clinical Features of Patients with Dysthymia in a Large Cohort of Han Chinese Women with Recurrent Major Depression

Yunchun Chen Xiaohong Hong Wenyuan Wu Guibing Chen Min Cai Yan Song Jiyang Pan Jicheng Dong Runde Pan Wei Zhang Zhenming Shen Zhengrong Liu Danhua Gu Xiaoping Wang Xiaojuan Liu Qiwen Zhang Yihan Li Yiping

Suicidal Risk Factors of Recurrent Major Depression in Han Chinese Women

Xiaohong Hong Wenyuan Wu Guibing Chen Min Cai Yan Song Jiyang Pan Jicheng Dong Runde Pan Wei Zhang Zhenming Shen Zhengrong Liu Danhua Gu Xiaoping Wang Xiaojuan Liu Qiwen Zhang Yihan Li Yiping Chen Kenneth