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Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa

: Uma Gaur, Jianbo Tu, Yue Gao, Ting Lian, Xiaolan Fan. Formal analysis: Jianbo Tu, Diyan Li, Boyuan Sun. Funding acquisition: Mingyao Yang. Investigation: Jianbo Tu, Diyan Li, Ting Lian. Methodology ... : Boyuan Sun, Deying Yang. Resources: Deying Yang, Xiaolan Fan. Supervision: Mingyao Yang. Validation: Yue Gao. Visualization: Xiaolan Fan. Writing ± original draft: Uma Gaur. Writing ± review

Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development

The Jun N-terminal kinase pathway plays an important role in inducing programmed cell death (apoptosis) and is activated in a variety of contexts. The deubiquitinating enzymes (DUBs) are proteases regulating the protein stability by ubiquitin-proteasome system. Here, for the first time, we report the phenotypes observed during eye development that are induced by deleting...

Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease

Background New strategies for the treatment of Parkinson's disease (PD) are shifted from dopamine (DA) replacement to regeneration or restoration of the nigro-striatal system. A cell therapy using human retinal pigment epithelial (RPE) cells as substitution for degenerated dopaminergic (DAergic) neurons has been developed and showed promising prospect in clinical treatment of PD...