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Zircon U-Pb geochronology of crystal tuff on Lingshan Island and its geological implications for magmatism, stratigraphic age and geological events

, Shaanxi, 710069, ChinaJindong Gao, Xiaoli Zhang, Lifa Zhou & Yu QinQingdao National Laboratory for Marine Science and Technology, College of Earth Science and Engineering, Shandong University of Science and ... • Google Scholar Search for Xiaoli Zhang in:Nature Research journals • PubMed • Google Scholar Search for Lifa Zhou in:Nature Research journals • PubMed • Google Scholar Search for Zunsheng Jiao in:Nature

The efficacy and safety of alectinib in the treatment of ALK+ NSCLC: a systematic review and meta-analysis

The efficacy and safety of alectinib in the treatment of ALK+ NSCLC: a systematic review and meta-analysis Junsheng Fan,1,2,* Zengfei Xia,1,* Xiaoli Zhang,1,* Yuqing Chen,1 Ruolan Qian,1 Sihan Liu,1

The applications of liquid biopsy in resistance surveillance of anaplastic lymphoma kinase inhibitor

The applications of liquid biopsy in resistance surveillance of anaplastic lymphoma kinase inhibitor Yating Chen,1,* Wenjie Guo,1,* Junsheng Fan,2,* Yuqing Chen,1 Xiaoli Zhang,1 Xin Chen,1 Peng Luo1

The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer

The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer Wenjie Guo,1,* Sihan Liu,2,* Xiaoli Zhang,1,* Yating Chen,1 Ruolan Qian,1 Ziyuan Zou,2 Xin

MiR-34a regulates the invasive capacity of canine osteosarcoma cell lines

acquisition. Author Contributions Conceptualization: Cheryl A. London, Joelle M. Fenger. Data curation: Cecilia M. Lopez, Peter Y. Yu, Joelle M. Fenger. Formal analysis: Peter Y. Yu, Xiaoli Zhang, Ayse

Assessing the Economic Costs of Water Pollution in the Yangtze River, China

Water pollution of the Yangtze River basin is very serious. Studies have shown that from the upper to the lower river, the water volume decreases and development and pollution increase, especially in trans-boundary areas. The Yangtze Estuary is located at the intersection of Jiangsu Province and Shanghai where the waters flow directly into the East China Sea. The estuary provides...

CLDN6 promotes chemoresistance through GSTP1 in human breast cancer

Claudin-6 (CLDN6), a member of CLDN family and a key component of tight junction, has been reported to function as a tumor suppressor in breast cancer. However, whether CLDN6 plays any role in breast cancer chemoresistance remains unclear. In this study, we investigated the role of CLDN6 in the acquisition of chemoresistance in breast cancer cells. We manipulated the expression...

Dysregulation of hepatic microRNA expression profiles with Clonorchis sinensis infection

Xiaoli Zhang 1 Jianping Cao 0 3 0 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, Ministry of Health, MOH

[68Ga]Pentixafor-PET/MRI for the detection of Chemokine receptor 4 expression in atherosclerotic plaques

PurposeThe expression of chemokine receptor type 4 (CXCR4) was found co-localized with macrophages on the atherosclerotic vessel wall and participated in the initial emigration of leukocytes. Gallium-68 [68Ga]Pentixafor has recently been introduced for the imaging of atherosclerosis by targeting CXCR4. We sought to evaluate human atherosclerotic lesions using [68Ga]Pentixafor PET...

Development and Evaluation of Up-Converting Phosphor Technology-Based Lateral Flow Assay for Quantitative Detection of NT-proBNP in Blood

A newly assay, up-converting phosphor technology-based lateral flow (UPT-LF) assay, was developed for rapid and quantitative detection of N-terminal fragment of B-type natriuretic peptide precursor (NT-proBNP), one of the most important serum molecular maker of heat failure, in plasma samples as a point of care testing (POCT) method for diagnosis of acute heart failure. Human...

MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines

Background MicroRNAs (miRNAs) regulate the expression of networks of genes and their dysregulation is well documented in human malignancies; however, limited information exists regarding the impact of miRNAs on the development and progression of osteosarcoma (OS). Canine OS exhibits clinical and molecular features that closely resemble the corresponding human disease and it is...

Involved-field radiotherapy for esophageal squamous cell carcinoma: theory and practice

Esophageal carcinoma (EC) is characterized by a high rate of lymph node metastasis and its spread pattern is not always predictable. Chemoradiotherapy has an important role in the treatment of EC in both the inoperable and the pre-operative settings. However, regarding the target volume for radiation, different clinical practices exist. Theoretically, in addition to the clinical...

Decreased Functional Connectivity of Homotopic Brain Regions in Chronic Stroke Patients: A Resting State fMRI Study

The recovery of motor functions is accompanied by brain reorganization, and identifying the inter-hemispheric interaction post stroke will conduce to more targeted treatments. However, the alterations of bi-hemispheric coordination pattern between homologous areas in the whole brain for chronic stroke patients were still unclear. The present study focuses on the functional...

Immunohistochemical Study of Expression of Sohlh1 and Sohlh2 in Normal Adult Human Tissues

The expression pattern of Sohlh1 (spermatogenesis and oogenesis specific basic helix-loop-helix 1) and Sohlh2 in mice has been reported in previous studies. Sohlh1 and Sohlh2 are specifically expressed in spermatogonia, prespermatogonia in male mice and oocytes of primordial and primary follicles in female mice. In this report, we studied the expression pattern of Sohlh1 and...

Immunization with Heat Shock Protein A and γ-Glutamyl Transpeptidase Induces Reduction on the Helicobacter pylori Colonization in Mice

The human gastric pathogen Helicobacter pylori (H. pylori) is a successful colonizer of the stomach. H. pylori infection strongly correlates with the development and progression of chronic gastritis, peptic ulcer disease, and gastric malignances. Vaccination is a promising strategy for preventing H. pylori infection. In this study, we evaluated the candidate antigens heat shock...

Whole Brain Radiotherapy Plus Concurrent Chemotherapy in Non-Small Cell Lung Cancer Patients with Brain Metastases: A Meta-Analysis

Objective The aim of the present meta-analysis is to evaluate the response rate, median survival time (MST) and toxicity in patients with brain metastases (BM) originating from non-small cell lung cancer (NSCLC) and who were treated using either whole brain radiotherapy (WBRT) plus concurrent chemotherapy or WBRT alone. Methods PubMed, EMBASE, Web of Science, The Cochrane Library...

A Protein-Based Hydrogel for In Vitro Expansion of Mesenchymal Stem Cells

Hydrogels are widely used as scaffolds in tissue engineering because they can provide excellent environments for bioactive components including growth factors and cells. We reported in this study on a physical hydrogel formed by a specific protein-peptide interaction, which could be used for the three dimensional (3D) cell culture of murine mesenchymal stem cells (mMSC). The mMSC...

PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

Background The therapeutic and prognostic value of the glycolytic enzymes hexokinase, phosphofructokinase, and pyruvate kinase (PK) has been implicated in a variety of cancers, while their roles in treatment of and prognosis for hilar cholangiocarcinoma (HC) remain unclear. In this study, we determined the expression of PKM2 in and its impact on biology and clinical outcome of...

Twist 1 regulates the expression of PPARγ during hormone-induced 3T3-L1 preadipocyte differentiation: a possible role in obesity and associated diseases

Background Twist 1 is highly expressed in adipose tissue and has been associated with obesity and related disorders. However, the molecular function of Twist 1 in adipose tissue is unclear. Twist 1 has been implicated in cell lineage determination and differentiation. Therefore, we investigated both the role of Twist 1 in adipocyte precursor mobilization and the relationship of...

Erratum to: Quantitative assessment of atherosclerotic plaques on 18F-FDG PET/MRI: comparison with a PET/CT hybrid system

, Vienna , Austria Markus Hartenbach 1 & Alexander Haug 1 & Xiaoli Zhang 6 & Christian Loewe 2 & in the name of Markus Mitthauser. It should have been