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Demographic and socioeconomic factors influencing the incidence of ankle fractures, a national population-based survey of 512187 individuals

Chen in:Nature Research journals • PubMed • Google Scholar Search for Lin Wang in:Nature Research journals • PubMed • Google Scholar Search for Xiaolin Zhang in:Nature Research journals • PubMed ... • Google Scholar Search for Yingze Zhang in:Nature Research journals • PubMed • Google Scholar Contributions Yingze Zhang designed the study. Wei Chen and Lin Wang searched relevant studies. Xiaolin Zhang

Optimization Design of IGV Profile in Centrifugal Compressor

Variable inlet guide vane (IGV) is used to control the mass flow and generate prewhirl in centrifugal compressors. The efficient operation of IGV is limited to the range of aerodynamic characteristics of their vane profiles. In order to find out the best vane profile for IGV regulation, the modern optimization method was adopted to optimize the inlet guide vane profile. The main...

Identification of new type I interferon-stimulated genes and investigation of their involvement in IFN-β activation

-stimulated genes; IFN-β signaling; PIM1; RIG-I; MDA5 - Xiaolin Zhang and Wei Yang have contributed equally to this work. specifically inhibits RIG-I- and MDA5-mediated IFN-β signaling. Our results expand the

Mid-Cretaceous carbon cycle perturbations and Oceanic Anoxic Events recorded in southern Tibet

Academy of Sciences, Nanjing 210008, ChinaJingeng Sha AuthorsSearch for Xiaolin Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Kefan Chen in:Nature Research journals • PubMed • Google ... Correspondence to Xiaolin Zhang. Supplementary information PDF files1.Supplementary Information Rights and permissions This work is licensed under a Creative Commons Attribution 4.0 International

An AGC system with a PGA for GPS/BDS dual system compatible receiver

University, Beijing, P. R. China. His research interests include RF integrated-circuit design. Xiaolin Zhang received the Ph.D. degree in electronic information engineering from Beihang University, Beijing, P

M2BP inhibits HIV-1 virion production in a vimentin filaments-dependent manner

AffiliationsCAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, ChinaQin Wang, Xiaolin Zhang, Yuling Han, Xinlu Wang & Guangxia GaoUniversity of ... Chinese Academy of Sciences, Beijing, 100049, ChinaQin Wang, Xiaolin Zhang & Yuling Han AuthorsSearch for Qin Wang in:Nature Research journals • PubMed • Google ScholarSearch for Xiaolin Zhang in:Nature

Flame Image Segmentation Based on the Bee Colony Algorithm with Characteristics of Levy Flights

of Science and Technology, Baotou 014010, China Received 21 April 2015; Accepted 26 May 2015 Academic Editor: Xiaoyu Song Copyright © 2015 Xiaolin Zhang et al. This is an open access article

Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus

Background The mechanisms leading to the high on-treatment platelet reactivity in diabetes patients are not fully elucidated. The genetic factors may be associated with the diminished antiplatelet efficacy of dual antiplatelet therapy. We investigated the possible association between insulin receptor substrate-1 (IRS-1) polymorphisms and high platelet reactivity in coronary...

Adaptive Evolution of Synthetic Cooperating Communities Improves Growth Performance

Symbiotic interactions between organisms are important for human health and biotechnological applications. Microbial mutualism is a widespread phenomenon and is important in maintaining natural microbial communities. Although cooperative interactions are prevalent in nature, little is known about the processes that allow their initial establishment, govern population dynamics and...

Development of open access in China: strategies, practices, challenges

China's rapid growth in scientific R&D in recent years provides solid evidence for the country's innovation-driven development strategy, but also puts increasing demand on open access (OA) to publicly funded research results. This article looks at ways in which the Chinese government, funders, research and library communities are all rising to this challenge, and at future...

Up-Regulation of CREG Expression by the Transcription Factor GATA1 Inhibits High Glucose- and High Palmitate-Induced Apoptosis in Human Umbilical Vein Endothelial Cells

Background Endothelial cell (EC) apoptosis plays a vital role in the pathogenesis of atherosclerosis in patients with diabetes mellitus (DM), but the underlying mechanism remains unclear. Cellular repressor of E1A-stimulated genes (CREG) is a novel gene reported to be involved in maintaining the homeostasis of ECs. Therefore, in the present study, we investigated the role of CREG...

Genotoxicity Evaluation of Irrigative Wastewater from Shijiazhuang City in China

In the present study, the wastewater sample collected from the Dongming discharging river in Shijiazhuang city was analysed using both chemical analysis and biological assays including the Salmonella mutagenicity test, micronucleus test and single-cell gel electrophoresis. Chemical analysis of the sample was performed using gas chromatography mass spectrometry and inductively...

Elevated Levels of Dickkopf-1 Are Associated with β-Catenin Accumulation and Poor Prognosis in Patients with Chondrosarcoma

Background Dickkopf-1 (DKK1) is an antagonist of Wnt/β-catenin signaling implicated in tumorigenesis. However, the biological role of DKK1 and β-catenin involved in chondrosarcoma has not been sufficiently investigated. This study was designed to investigate the expression profiles of DKK1 and β-catenin, and to clarify their clinical values in chondrosarcoma. Methods The mRNA and...

Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization

Background Tumor-associated macrophages (TAMs) are the major component of tumor-infiltrating leukocytes. TAMs are heterogeneous, with distinct phenotypes influenced by the microenvironment surrounding tumor tissues, but relatively little is known about the key molecular in these cells that contribute to malignant phenotypes. Autophagic activity is a critical factor in tumor...

An Analysis of 1256 Cases of Sporadic Ruptured Cerebral Aneurysm in a Single Chinese Institution

Background To review the epidemiology of sporadic ruptured cerebral aneurysm. Methods This is a retrospective study of consecutive 1256 Chinese patients between January 2006 and January 2013, who were admitted to the Second Hospital of Hebei Medical University, China, for spontaneous subarachnoid hemorrhage due to a rupture of cerebral artery aneurysm. In 288 males and 478...

A 14C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague–Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite

Leucine is an essential branched-chain amino acid that acts as a substrate for protein synthesis and as a signaling molecule. Leucine not incorporated into muscle protein is ultimately oxidized through intermediates such as β-hydroxy-β-methylbutyrate (HMB) which itself is reported to enhance muscle mass and function in rats and humans. HMB has been reported in the plasma...

Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic, for topical skin therapy

Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic, for topical skin therapy Chong Li, Xiaolin Zhang, Xinliang Huang, Xiaoying Wang, Guojian Liao

Tumor-targeted liposomal drug delivery mediated by a diseleno bond-stabilized cyclic peptide

Tumor-targeted liposomal drug delivery mediated by a diseleno bond-stabilized cyclic peptide Chong Li,1,2 Yixin Wang,3 Xiaolin Zhang,1 Li Deng,1 Yan Zhang,1 Zhangbao Chen1 1Key Laboratory on

Development and validation of a chromatographic method for determining Clematichinenoside AR and related impurities

Background Clematichinenoside AR is a promising lead compound for the treatment of rheumatoid arthritis. A systematic research for the related impurities in AR bulk samples is still lacking. For the safe use of this natural product in future clinical practice, the structure and content of each constituent, including the main ingredient as well as the impurities in AR bulk sample...

Integrative Computational and Experimental Approaches to Establish a Post-Myocardial Infarction Knowledge Map

Vast research efforts have been devoted to providing clinical diagnostic markers of myocardial infarction (MI), leading to over one million abstracts associated with “MI” and “Cardiovascular Diseases” in PubMed. Accumulation of the research results imposed a challenge to integrate and interpret these results. To address this problem and better understand how the left ventricle...