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Enhanced production of polysaccharides and triterpenoids in Ganoderma lucidum fruit bodies on induction with signal transduction during the fruiting stage

. Investigation: Liyun Ye, Fan Xie, Lili Zhao. Supervision: Xiaoping Wu. Validation: Xiaoping Wu. Writing ± original draft: Liyun Ye, Shengrong Liu. Writing ± review & editing: Shengrong Liu. 13 / 15 14 / 15

Genetic structure and diversity of Nodularia douglasiae (Bivalvia: Unionida) from the middle and lower Yangtze River drainage

Project (No. 18000041). This article is contribution 92 of the Central Michigan University Institute for Great Lakes Research. Author Contributions Conceptualization: Xiongjun Liu, Xiaoping Wu. Data ... curation: Xiongjun Liu, David T. Zanatta, Xiaoping Wu. Formal analysis: Xiongjun Liu, David T. Zanatta, Xiaoping Wu. Funding acquisition: Shan Ouyang, Xiaoping Wu. Investigation: Xiongjun Liu, Taotao Xue

A 0.5-Mbp deletion on bovine chromosome 23 is a strong candidate for stillbirth in Nordic Red cattle

Background A whole-genome association study of 4631 progeny-tested Nordic Red dairy cattle bulls using imputed next-generation sequencing data revealed a major quantitative trait locus (QTL) that affects birth index (BI) on Bos taurus autosome (BTA) 23. We analyzed this QTL to identify which of the component traits of BI are affected and understand its molecular basis. Results A...

The effect of dams on the larval abundance and composition of four carp species in key river systems in China

The four species of carp present in China (grass carp, black carp, silver carp and bighead carp) are all commercially important freshwater fish species. However, the construction of large-scale hydraulic projects, such as dams, along with other anthropogenic changes to river systems has resulted in the rapid decline in abundance of all four carp species. Indeed, the effect of...

Association analysis for udder health based on SNP-panel and sequence data in Danish Holsteins

Background The sensitivity of genome-wide association studies for the detection of quantitative trait loci (QTL) depends on the density of markers examined and the statistical models used. This study compares the performance of three marker densities to refine six previously detected QTL regions for mastitis traits: 54 k markers of a medium-density SNP (single nucleotide...

Water solubility in orthopyroxene: Dependence on temperature and Al content

The water solubility in Al-Fe-Mg orthopyroxene [(Mg,Fe,Al)(Si,Al)O3: X Fe = 0.1] was investigated as a function of temperature and Al contents. Experiments were performed at 10 kbar with temperatures ranging from 800 to 1200°C under water-saturated conditions. Water contents in the (Mg,Fe)SiO3-H2O-Al2O3 system were determined using unpolarized Fourier transform infrared...

Apolipoprotein E polymorphism is associated with lower extremity deep venous thrombosis: color-flow Doppler ultrasound evaluation

Introduction Apolipoprotein E (apoE) is a member of apolipoprotein family, and its gene polymorphisms seem to have some impact among patients with cardiovascular disease. However, its role in the lower extremity deep venous thrombosis (LEDVT) has not been well studied. The objective of this study was to investigate the potential association between APOE gene polymorphisms and...

Correction: Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†

Ken Hull Zhou Zhou Mingzhao Zhu Xiaoping Wu David J. Tweardy Daniel Romo Xiaoyun Fu Yanjun Zhang Jianning Zhang Jing-fei Dong The seventh author's name is incorrect. The correct name is: Mingzhao Zhu

Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†

Background Piperlongumine (PL) is a compound isolated from the piper longum plant. It possesses anti-cancer activities through blocking the transcription factor STAT3 and by inducing reactive oxygen species (ROS) in cancer, but not normal cells. It also inhibits platelet aggregation induced by collagen, but the underlying mechanism is not known. Objective We conducted in vitro...

Correcting for Strong Eddy Current Induced B0 Modulation Enables Two-Spoke RF Pulse Design with Parallel Transmission: Demonstration at 9.4T in the Human Brain

Successful implementation of homogeneous slice-selective RF excitation in the human brain at 9.4T using 16-channel parallel transmission (pTX) is demonstrated. A novel three-step pulse design method incorporating fast real-time measurement of eddy current induced B0 variations as well as correction of resulting phase errors during excitation is described. To demonstrate the...

Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein

Detecting genes associated with milk fat composition could provide valuable insights into the complex genetic networks of genes underling variation in fatty acids synthesis and point towards opportunities for changing milk fat composition via selective breeding. In this study, we conducted a genome-wide association study (GWAS) for 22 milk fatty acids in 784 Chinese Holstein cows...

Genome wide association studies for body conformation traits in the Chinese Holstein cattle population

Background Genome-wide association study (GWAS) is a powerful tool for revealing the genetic basis of quantitative traits. However, studies using GWAS for conformation traits of cattle is comparatively less. This study aims to use GWAS to find the candidates genes for body conformation traits. Results The Illumina BovineSNP50 BeadChip was used to identify single nucleotide...

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid β (Aβ)-induced synaptic stress and the loss of synapses relevant to the pathogenesis of Alzheimer’s disease (AD). However, the mechanisms controlling axonal mitochondrial...

Elevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients

Background Elevation of soluble major histocompatibility complex class I chain-related gene A (sMICA) products in serum has been linked to tissue/organ transplantation, autoimmune diseases and some malignant disorders. Cells infected by microbiological pathogens may release sMICA, whereas less is known whether and to what extent serum sMICA levels may change in infectious...

Recombinant avian leukosis viruses of subgroup J isolated from field infected commercial layer chickens with hemangioma and myeloid leukosis possess an insertion in the E element

Xiaoping Wu Kun Qian Aijian Qin Haiyu Shen Pingping Wang Wenjie Jin Yassir Mohammed Eltahir K. Qian e-mail: Background Five isolates (JS09GY2, JS09GY3, JS09GY4, JS09GY5, and JS09GY6) of avian ... in any medium, provided the original author(s) and source are credited. Dr Qin supervised all of the research. Xiaoping Wu and Dr. Qin were responsible for the histopathological examination, virus

Developmental expression and function of DKKL1/Dkkl1 in humans and mice

BackgroundExperiments were designed to identify the developmental expression and function of the Dickkopf-Like1 (DKKL1/Dkkl1) gene in humans and mice.MethodsMouse testes cDNA samples were collected at multiple postnatal times (days 4, 9, 18, 35, and 54, as well as at 6 months) and hybridized to Affymetrix mouse whole genome Genechips. To further characterize the homologous gene...

A Better Anti-Diabetic Recombinant Human Fibroblast Growth Factor 21 (rhFGF21) Modified with Polyethylene Glycol

As one of fibroblast growth factor (FGF) family members, FGF21 has been extensively investigated for its potential as a drug candidate to combat metabolic diseases. In the present study, recombinant human FGF21 (rhFGF21) was modified with polyethylene glycol (PEGylation) in order to increase its in vivo biostabilities and therapeutic potency. At N-terminal residue rhFGF21 was...