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Electrophysiological characteristics of pressure overload-induced cardiac hypertrophy and its influence on ventricular arrhythmias

checklist. (PDF) Author Contributions Conceptualization: Mu Qin, Xu Liu. Data curation: Xiaowei Chen, Mu Qin, Xu Liu. Formal analysis: Xiaowei Chen, Mu Qin, Xu Liu. Funding acquisition: Xu Liu ... . Investigation: Weifeng Jiang, Yu Zhang. Resources: Xiaowei Chen, Mu Qin, Weifeng Jiang, Yu Zhang. Supervision: Xu Liu. Writing ± original draft: Xiaowei Chen, Mu Qin. Writing ± review & editing: Xiaowei Chen

Special issue on computational optimization and intelligence in uncertain environment

Xiaowei Chen 2 School of Information Technology and Management, University of International Business and Economics , Beijing , China 3 School of Management, University of Chinese Academy of Sciences

Asian Option Pricing Formula for Uncertain Financial Market

Asian option is an important financial derivative instrument. It has been widely accepted by investors for its risk management property. Uncertain finance is a new field where the risk processes are described by uncertain processes. An asset price is assumed to follow a specific uncertain differential equation other than a stochastic differential equation. In this paper, Asian ...

Uncertain Multiobjective Programming and Uncertain Goal Programming

Multiobjective programming, known as multi-criteria or multi-attribute optimization, is the process of simultaneously optimizing two or more conflicting objectives. This paper aims to provide a new multiobjective programming named uncertain multiobjective programming that is a type of multiobjective programming involving uncertain variables. Some mathematical properties are also ...

Uncertain systems are universal approximators

Uncertain inference is a process of deriving consequences from uncertain knowledge or evidences via the tool of conditional uncertain set. Based on uncertain inference, uncertain system is a function from its inputs to outputs. This paper proves that uncertain systems are universal approximators, which means that uncertain systems are capable of approximating any continuous ...

A novel approach identifies the first transcriptome networks in bats: a new genetic model for vocal communication

Background Bats are able to employ an astonishingly complex vocal repertoire for navigating their environment and conveying social information. A handful of species also show evidence for vocal learning, an extremely rare ability shared only with humans and few other animals. However, despite their potential for the study of vocal communication, bats remain severely understudied at ...

Sensory Response of Transplanted Astrocytes in Adult Mammalian Cortex In Vivo

Glial precursor transplantation provides a potential therapy for brain disorders. Before its clinical application, experimental evidence needs to indicate that engrafted glial cells are functionally incorporated into the existing circuits and become essential partners of neurons for executing fundamental brain functions. While previous experiments supporting for their functional ...

Liu process and uncertain calculus

Uncertain calculus is a branch of mathematics that deals with the integral and differential of functions of uncertain processes. This paper first introduces the Liu process as an uncertain process defined by the Liu integral. Some properties of Liu processes are investigated such as sample continuity property, finite variation property, and the fact that a continuously ...

Joint analysis of expression profiles from multiple cancers improves the identification of microRNA–gene interactions

Motivation: MicroRNAs (miRNAs) play a crucial role in tumorigenesis and development through their effects on target genes. The characterization of miRNA–gene interactions will lead to a better understanding of cancer mechanisms. Many computational methods have been developed to infer miRNA targets with/without expression data. Because expression datasets are in general limited in ...

Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma

During a survey of clinical rectal prolapse (RP) cases in the mouse population at MIT animal research facilities, a high incidence of RP in the lamellipodin knock-out strain, C57BL/6-Raph1tm1Fbg (Lpd-/-) was documented. Upon further investigation, the Lpd-/- colony was found to be infected with multiple endemic enterohepatic Helicobacter species (EHS). Lpd-/- mice, a transgenic ...

Adjustment of familial relatedness in association test for rare variants

High-throughput sequencing technology allows researchers to test associations between phenotypes and all the variants identified throughout the genome, and is especially useful for analyzing rare variants. However, the statistical power to identify phenotype-associated rare variants is very low with typical genome-wide association studies because of their low allele frequencies ...

A penalized linear mixed model for genomic prediction using pedigree structures

Genetic Analysis Workshop 18 provided a platform for evaluating genomic prediction power based on single-nucleotide polymorphisms from single-nucleotide polymorphism array data and sequencing data. Also, Genetic Analysis Workshop 18 provided a diverse pedigree structure to be explored in prediction. In this study, we attempted to combine pedigree information with single-nucleotide ...

Admixture mapping analysis in the context of GWAS with GAW18 data

Admixture mapping is a disease-mapping strategy to identify disease susceptibility variants in an admixed population that is a result of mating between 2 historically separated populations differing in allele frequencies and disease prevalence. With the increasing availability of high-density genotyping data generated in genome-wide association studies, it is of interest to ...

Large-scale study of long non-coding RNA functions based on structure and expression features

Mammals and other complex organisms can transcribe an abundance of long non-coding RNAs (lncRNAs) that fulfill a wide variety of regulatory roles in many biological processes. These roles, including as scaffolds and as guides for protein-coding genes, mainly depend on the structure and expression level of lncRNAs. In this review, we focus on the current methods for analyzing lncRNA ...

Deep Profiling of the Novel Intermediate-Size Noncoding RNAs in Intraerythrocytic Plasmodium falciparum

Intermediate-size noncoding RNAs (is-ncRNAs) have been shown to play important regulatory roles in the development of several eukaryotic organisms. However, they have not been thoroughly explored in Plasmodium falciparum, which is the most virulent malaria parasite infecting human being. By using Illumina/Solexa paired-end sequencing of an is-ncRNA-specific library, we performed a ...

Identifying a Highly-Aggressive DCIS Subgroup by Studying Intra-Individual DCIS Heterogeneity among Invasive Breast Cancer Patients

The heterogeneity among multiple ductal carcinoma in situ (DCIS) lesions within the same patient also diagnosed with invasive ductal carcinoma (IDC) has not been well evaluated, leaving research implications of intra-individual DCIS heterogeneity yet to be explored. In this study formalin-fixed paraffin embedded sections from 36 patients concurrently diagnosed with DCIS and IDC ...

Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome

Background The significant mortality associated with breast cancer (BCa) suggests a need to improve current research strategies to identify new genes that predispose women to breast cancer. Differential allele-specific expression (DASE) has been shown to contribute to phenotypic variables in humans and recently to the pathogenesis of cancer. We previously reported that ...

Predicting Housekeeping Genes Based on Fourier Analysis

Housekeeping genes (HKGs) generally have fundamental functions in basic biochemical processes in organisms, and usually have relatively steady expression levels across various tissues. They play an important role in the normalization of microarray technology. Using Fourier analysis we transformed gene expression time-series from a Hela cell cycle gene expression dataset into ...

A baculovirus dual expression system-based vaccine confers complete protection against lethal challenge with H9N2 avian influenza virus in mice

Background Avian influenza viruses of H9N2 subtype have become highly prevalent in avian species. Although these viruses generally cause only mild to moderate disease, they can infect a wide variety of species, including chickens, quail, turkeys, ducks, geese, pheasant, partridge, and pigeon, even transmitted to mammalian species, including humans, accelerating the efforts to ...

The novel long non-coding RNA CRG regulates Drosophila locomotor behavior

Long non-coding RNAs (lncRNAs) that have no protein-coding capacity make up a large proportion of the transcriptome of various species. Many lncRNAs are expressed within the animal central nervous system in spatial- and temporal-specific patterns, indicating that lncRNAs play important roles in cellular processes, neural development, and even in cognitive and behavioral processes. ...