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EARLY EFFECTS OF LOW DOSE 12C6+ ION OR X-RAY IRRADIATION ON PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH ALIMENTARY TRACT CANCER

China Xiaowei Zhang Central Laboratory of the First Hospital of Lanzhou University, People’s Republic of China Huizi Ren Tumor Hospital of Institute of Medical Science of Gansu Province, People’s Republic

Synthetic regulatory RNAs selectively suppress the progression of bladder cancer

The traditional treatment for cancer is lack of specificity and efficacy. Modular synthetic regulatory RNAs, such as inhibitive RNA (iRNA) and active RNA (aRNA), may overcome these limitations. Here, we synthesize a new iRNA to bind the upstream activating sequence (UAS) of a minimal promoter that drives expression of artificial miRNAs (amiRNAs) targeting MYC, which represses the...

Indigenous species barcode database improves the identification of zooplankton

supported by the Collaborative Innovation Center for Regional Environmental Quality. 12 / 15 Author Contributions Conceptualization: Xiaowei Zhang, G. Allen Burton, Jr. Data curation: Jianghua Yang, Yuwei ... Xie. Formal analysis: Wanwan Zhang. Funding acquisition: Xiaowei Zhang. Investigation: Jingying Sun, Yuwei Xie. Methodology: Wanwan Zhang, Jingying Sun. Project administration: Jianghua Yang

Regeneration of hyaline-like cartilage in situ with SOX9 stimulation of bone marrow-derived mesenchymal stem cells

Microfracture, a common procedure for treatment of cartilage injury, induces fibrocartilage repair by recruiting bone marrow derived mesenchymal stem cells (MSC) to the site of cartilage injury. However, fibrocartilage is inferior biomechanically to hyaline cartilage. SRY-type high-mobility group box-9 (SOX9) is a master regulator of chondrogenesis by promoting proliferation and...

Bmi-1 regulates stem cell-like properties of gastric cancer cells via modulating miRNAs

Background B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) plays an important role in regulating stemness in some kinds of cancer. However, the mechanisms remain unclear. This study was to investigate whether and how Bmi-1 regulates stemness of gastric cancer. Methods We firstly explored the role of Bmi-1 in regulating stem cell-like features in gastric...

Estimate Hand Poses Efficiently from Single Depth Images

This paper aims to tackle the practically very challenging problem of efficient and accurate hand pose estimation from single depth images. A dedicated two-step regression forest pipeline is proposed: given an input hand depth image, step one involves mainly estimation of 3D location and in-plane rotation of the hand using a pixel-wise regression forest. This is utilized in step...

Hyperuricemia and the risk for coronary heart disease morbidity and mortality a systematic review and dose-response meta-analysis

, Nanchang 330006, People’s Republic of ChinaMin Li, Kun Li, Xiaowei Zhang, Wenshang Hou & Zhenyu TangDepartment of Anaesthesiology, The Second Affiliated Hospital to Nanchang University, Nanchang 330006 ... Li in:Nature Research journals • PubMed • Google ScholarSearch for Xiaowei Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Wenshang Hou in:Nature Research journals • PubMed

DELLA proteins are common components of symbiotic rhizobial and mycorrhizal signalling pathways

for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, ChinaYue Jin, Huan Liu, Dexian Luo, Wentao Dong, Chao Wang, Xiaowei Zhang, Huiling Dai, Jun Yang & Ertao WangUniversity of Chinese ... journals • PubMed • Google ScholarSearch for Xiaowei Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Huiling Dai in:Nature Research journals • PubMed • Google ScholarSearch for Jun Yang

Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway

Background Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines in TBEV-mediated neurological disease are poorly understood...

A One-Layer Recurrent Neural Network for Solving Pseudoconvex Optimization with Box Set Constraints

A one-layer recurrent neural network is developed to solve pseudoconvex optimization with box constraints. Compared with the existing neural networks for solving pseudoconvex optimization, the proposed neural network has a wider domain for implementation. Based on Lyapunov stable theory, the proposed neural network is proved to be stable in the sense of Lyapunov. By applying...

Enhanced photovoltaic property by forming p-i-n structures containing Si quantum dots/SiC multilayers

Si quantum dots (Si QDs)/SiC multilayers were fabricated by annealing hydrogenated amorphous Si/SiC multilayers prepared in a plasma-enhanced chemical vapor deposition system. The thickness of amorphous Si layer was designed to be 4 nm, and the thickness of amorphous SiC layer was kept at 2 nm. Transmission electron microscopy observation revealed the formation of Si QDs after...

Theoretical and numerical analysis of coal dust separated by centrifugal force for working and heading faces

In order to meet engineering needs of Chinese underground coal mines, a new dust-collecting fan, a device of dust separated by centrifugal force in driven cyclone passageway (DCCP) was designed. In centrifugal dust removal section (CDRS) of DCCP, a general equation is derived from the principle of force equilibrium. According to CDRS structure parameters and fan running...

A Comprehensive Alanine-Scanning Mutagenesis Study Reveals Roles for Salt Bridges in the Structure and Activity of Pseudomonas aeruginosa Elastase

The relationship between salt bridges and stability/enzymatic activity is unclear. We studied this relationship by systematic alanine-scanning mutation analysis using the typical M4 family metalloprotease Pseudomonas aeruginosa elastase (PAE, also known as pseudolysin) as a model. Structural analysis revealed seven salt bridges in the PAE structure. We constructed ten mutants for...

Where less may be more: how the rare biosphere pulls ecosystems strings

journals • PubMed • Google ScholarSearch for Xiaowei Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Zhong Wei in:Nature Research journals • PubMed • Google ScholarSearch for W H Gera

Tunable nonlinear optical properties in nanocrystalline Si/SiO2 multilayers under femtosecond excitation

The nonlinear optical properties of nanocrystalline-Si/SiO2 (nc-Si/SiO2) multilayers have been investigated through Z-scan technique by using a Ti-sapphire laser with 50-fs pulse duration at 800 nm as a pump laser. It is interesting to note that with increasing the annealing temperature to make the sample change from amorphous phase to nanocrystalline state, the nonlinear...

Prognostic Value of FGFR Gene Amplification in Patients with Different Types of Cancer: A Systematic Review and Meta-Analysis

Zhang 0 Jin Li 0 Pirkko L. Harko nen, Institute of Biomedicine, Finland 0 Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan

MUC1 gene polymorphism rs4072037 and susceptibility to gastric cancer: a meta-analysis

The association between MUC1 polymorphism rs4072037 and the risk of gastric cancer has been described in several studies. However, these studies yielded inconsistent results, especially in different pathological type of gastric cancer. Therefore, we performed this meta-analysis to evaluate the relationship between MUC1 gene polymorphism and gastric cancer susceptibility. A...

Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4

Shortage of red blood cells (RBCs, erythrocytes) can have potentially life-threatening consequences for rare or unusual blood type patients with massive blood loss resulting from various conditions. Erythrocytes have been derived from human pluripotent stem cells (PSCs), but the risk of potential tumorigenicity cannot be ignored, and a majority of these cells produced from PSCs...

Perception, Price and Preference: Consumption and Protection of Wild Animals Used in Traditional Medicine

A wide array of wildlife species, including many animals, are used in traditional medicines across many medicinal systems, including in Traditional Chinese Medicine (TCM). Due to over-exploitation and habitat loss, the populations of many animals commonly used in TCM have declined and are unable to meet market demand. A number of measures have been taken to try to reduce the...

Differential reconstructed gene interaction networks for deriving toxicity threshold in chemical risk assessment

Background Pathway alterations reflected as changes in gene expression regulation and gene interaction can result from cellular exposure to toxicants. Such information is often used to elucidate toxicological modes of action. From a risk assessment perspective, alterations in biological pathways are a rich resource for setting toxicant thresholds, which may be more sensitive and...