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Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population

donating blood samples. Author Contributions Conceptualization: Yi Zhao, Yuhong Zhang. Data curation: Yi Zhao. Formal analysis: Xiaoxia Li. Funding acquisition: Yuhong Zhang. Investigation: Xiaoxia Li ... : Xiaoxia Li, Yi Zhao. Writing ± review & editing: Jianjun Zhang, Yuhong Zhang. 10 / 12 24. Wasim H, Aldaghri NM, Chetty R, McTernan PG, Barnett AH, Kumar S. Relationship of serum adiponectin and resistin

Variation of DNA Methylome of Zebrafish Cells under Cold Pressure

DNA methylation is an essential epigenetic mechanism involved in multiple biological processes. However, the relationship between DNA methylation and cold acclimation remains poorly understood. In this study, Methylated DNA Immunoprecipitation Sequencing (MeDIP-seq) was performed to reveal a genome-wide methylation profile of zebrafish (Danio rerio) embryonic fibroblast cells (ZF4) ...

Carex jianfengensis (Carex sect. Rhomboidales, Cyperaceae), a New Species from Hainan, China

A new species of Carex sect. Rhomboidales, C. jianfengensis, is described and illustrated from Hainan, China. The new species is similar to C. zunyiensis but differs in having involucral bracts sparsely hispid and with ca.1 cm long sheaths; inflorescence with 4 spikes, terminal spike ca. 2.5 cm long, lateral spikes 2–3.5 × 0.7–1 cm; staminate glumes narrowly ovate, ca. 5 mm; ...

Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway

Background In tumor microenvironment, a continuous cross-talk between cancer cells and other cellular components is required to sustain tumor progression. Accumulating evidence suggests that exosomes, a novel way of cell communication, play an important role in such cross-talk. Exosomes could facilitate the direct intercellular transfer of proteins, lipids, and miRNA/mRNA/DNAs ...

Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis

adenomatous polyposis; Adenomatous polyposis coli; Colorectal cancer; Mutation analysis; Immunohistochemistry - Qi Liu and Xiaoxia Li contributed equally to this work. Introduction Familial adenomatous

Analysis of 116 cases of rectal cancer treated by transanal local excision

Background The purpose of this research was to evaluate the therapeutic effects and prognostic factors of transanal local excision (TAE) for rectal cancer. Methods We retrospectively analyzed 116 cases that underwent TAE for rectal cancer from 1995 to 2008. A Cox regression analysis was used to analyze prognostic factors. Results The survival times for the patients were from 14 to ...

Carex diaoluoshanica (Carex sect. Lageniformes, Cyperaceae), a New Species from Hainan, China

Carex diaoluoshanica, a new species of Carex sect. Lageniformes from Hainan, China, is described and illustrated. The new species is similar to C. breviscapa but differs in having wider leaves with the leaf base gradually narrowed, 5–10 cm long and petiolelike, culms subfiliform, with only two spikes, the lateral female spikes from near the culm base.

Regeneration Capacity of Small Clonal Fragments of the Invasive Mikania micrantha H.B.K.: Effects of Burial Depth and Stolon Internode Length

The perennial stoloniferous herbaceous vine Mikania micrantha H.B.K. is among the most noxious exotic invaders in China and the world. Disturbance can fragment stolons of M. micrantha and disperse these fragments over long distances or bury them in soils at different depths. To test their regeneration capacity, single-node stolon fragments with stolon internode lengths of 0, 3, 6 ...

The large-scale investigation of gene expression in Leymus chinensis stigmas provides a valuable resource for understanding the mechanisms of poaceae self-incompatibility

Background Many Poaceae species show a gametophytic self-incompatibility (GSI) system, which is controlled by at least two independent and multiallelic loci, S and Z. Until currently, the gene products for S and Z were unknown. Grass SI plant stigmas discriminate between pollen grains that land on its surface and support compatible pollen tube growth and penetration into the ...

Transcriptome Analysis Reveals Common and Distinct Mechanisms for Sheepgrass (Leymus chinensis) Responses to Defoliation Compared to Mechanical Wounding

Background Herbivore grazing is a multiple-component process that includes wounding, defoliation, and saliva deposition. Despite the extensive published research on mechanical wounding and defoliation, no analysis to identify the genes that specify defoliation and mechanical wounding has been performed. Moreover, the influence of the expression of these genes on plant regrowth ...

Therapeutic Role of Ursolic Acid on Ameliorating Hepatic Steatosis and Improving Metabolic Disorders in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Rats

Background Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases around the world, and is closely associated with obesity, diabetes, and insulin resistance. Ursolic acid (UA), an ubiquitous triterpenoid with multifold biological roles, is distributed in various plants. This study was conducted to investigate the therapeutic effect and potential ...

Nuciferine Prevents Hepatic Steatosis and Injury Induced by a High-Fat Diet in Hamsters

Background Nuciferine is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn that possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. However, it is currently unknown whether nuciferine can benefit hepatic lipid metabolism. Methodology/Principal Findings In the current study, male golden hamsters were randomly ...

A Novel Mouse Model of Campylobacter jejuni Gastroenteritis Reveals Key Pro-inflammatory and Tissue Protective Roles for Toll-like Receptor Signaling during Infection

Campylobacter jejuni is a major source of foodborne illness in the developed world, and a common cause of clinical gastroenteritis. Exactly how C. jejuni colonizes its host's intestines and causes disease is poorly understood. Although it causes severe diarrhea and gastroenteritis in humans, C. jejuni typically dwells as a commensal microbe within the intestines of most animals, ...

Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study

Background Lipoprotein lipase (LPL) and serum 25-hydroxyvitamin D [25(OH)D] play important roles in the regulation of lipid metabolism. Although dyslipidemia is associated with insulin resistance (IR) and type 2 diabetes (T2D), there are limited data available regarding the relationship of LPL and 25(OH)D to IR and T2D at a population level. The objective of the present study is to ...

Uroplakin Peptide-Specific Autoimmunity Initiates Interstitial Cystitis/Painful Bladder Syndrome in Mice

The pathophysiology of interstitial cystitis/painful bladder syndrome (IC/PBS) is enigmatic. Autoimmunity and impaired urothelium might lead the underlying pathology. A major shortcoming in IC/PBS research has been the lack of an appropriate animal model. In this study, we show that the bladder specific uroplakin 3A-derived immunogenic peptide UPK3A 65–84, which contains the ...

Duck Tembusu virus exhibits neurovirulence in BALB/c mice

Background Duck Tembusu virus is a member of the Ntaya group in the genus Flavivirus. The virus has been responsible for severe duck egg-drop syndrome in China since 2010. Its emergence and rapid spread have caused great economic loss for the poultry industry. The epidemiology of the virus infection and the potential threat to public health is of great concern because of the ...

Factors associated with willingness to participate in free HIV test among general residents in Heilongjiang, Northeast China

Background The human immunodeficiency virus (HIV) is spreading from high-risk groups, such as men who have sex with men (MSM) and sex workers, to the general population in China. This study examined the willingness of general residents in Heilongjiang, Northeast China, to participate in free HIV testing in the nearest health care setting, and the factors that may affect ...

Toll-Like Receptors are critical in controlling colonic inflammation and cancer

Li 1 0 Division of Gastroenterology, University of British Columbia and BC Children's Hospital , Vancouver, BC V6T 1Z4 , Canada 1 Department of Immunology, Cleveland Clinic Foundation , Cleveland, OH

Prostaglandin E2 Promotes Endothelial Differentiation from Bone Marrow-Derived Cells through AMPK Activation

Prostaglandin E2 (PGE2) has been reported to modulate angiogenesis, the process of new blood vessel formation, by promoting proliferation, migration and tube formation of endothelial cells. Endothelial progenitor cells are known as a subset of circulating bone marrow mononuclear cells that have the capacity to differentiate into endothelial cells. However, the mechanism underlying ...

Cadherin-11 in Renal Cell Carcinoma Bone Metastasis

Bone is one of the common sites of metastases from renal cell carcinoma (RCC), however the mechanism by which RCC preferentially metastasize to bone is poorly understood. Homing/retention of RCC cells to bone and subsequent proliferation are necessary steps for RCC cells to colonize bone. To explore possible mechanisms by which these processes occur, we used an in vivo metastasis ...