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The Nuclear Orphan Receptor Nur77 Alleviates Palmitate-induced Fat Accumulation by Down-regulating G0S2 in HepG2 Cells

Excessive triglyceride accumulation in hepatocytes is the hallmark of obesity-associated nonalcoholic fatty liver disease (NAFLD). Elevated levels of the saturated free fatty acid palmitate in obesity are a major contributor to excessive hepatic lipid accumulation. The nuclear orphan receptor Nur77 is a transcriptional regulator and a lipotoxicity sensor. Using human HepG2...

Epidemiology, microbiology, and treatment patterns of pediatric patients hospitalized with pneumonia at two hospitals in China: a patient chart review study

Yunqin Chen,2 David Melnick,3 Jesus Gonzalez,4 Judith Hackett,5 Xiaoyan Li,1 Zhaolong Cao6 1Key Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou ... , MD, Usa , USA 5 astraZeneca , Manchester , UK PowerdbyTCPDF(ww.tcpdf.org) O R i g i n a l R e s e a R C h huiling Xue 2 Jesus gonzalez 4 Judith hackett 5 Xiaoyan li 1 Background: The etiology

Nitric oxide balances osteoblast and adipocyte lineage differentiation via the JNK/MAPK signaling pathway in periodontal ligament stem cells

BackgroundCritical tissues that undergo regeneration in periodontal tissue are of mesenchymal origin; thus, investigating the regulatory mechanisms underlying the fate of periodontal ligament stem cells could be beneficial for application in periodontal tissue regeneration. Nitric oxide (NO) regulates many biological processes in developing embryos and adult stem cells. The...

A 6-year study of complicated urinary tract infections in southern China: prevalence, antibiotic resistance, clinical and economic outcomes

A 6-year study of complicated urinary tract infections in southern China: prevalence, antibiotic resistance, clinical and economic outcomes Xiaoyan Li,1,* Yunqin Chen,2,3,* Weiguo Gao,2 Hao Ye,2

Huaier extract restrains the proliferative potential of endocrine-resistant breast cancer cells through increased ATM by suppressing miR-203

, Qilu Hospital, Shandong University, Jinan, P.R. ChinaSumei Gao, Xiaoyan Li, Liyu Jiang & Qifeng YangDepartment of Oncology, Qilu Hospital, Shandong University, Jinan, P.R. ChinaXia DingPathology Tissue ... Bank, Qilu Hospital, Shandong University, Jinan, P.R. ChinaQifeng Yang AuthorsSearch for Sumei Gao in:Nature Research journals • PubMed • Google Scholar Search for Xiaoyan Li in:Nature Research journals

Veritable antiviral capacity of natural killer cells in chronic HBV infection: an argument for an earlier anti-virus treatment

There is limited information on innate immunity, especially natural killer (NK) cell function, in different chronic hepatitis B (CHB) stages. Therefore, we examined whether the clinical staging strategy accurately reflects veritable NK cell immunity. A total of 237 eligible CHB patients and 22 healthy controls were enrolled in our study. Demographic and clinical data were...

Assessing muscle spasticity with Myotonometric and passive stretch measurements: validity of the Myotonometer

Hermann Research Center, Houston, TX, USAXiaoyan Li, Henry Shin, Sheng Li & Ping Zhou AuthorsSearch for Xiaoyan Li in:Nature Research journals • PubMed • Google ScholarSearch for Henry Shin in:Nature ... . wrote the manuscript. All authors reviewed the manuscript. Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Xiaoyan Li. Rights and

Apixaban 5 and 2.5 mg twice-daily versus warfarin for stroke prevention in nonvalvular atrial fibrillation patients: Comparative effectiveness and safety evaluated using a propensity-score-matched approach

, Steve Deitelzweig. Writing ± original draft: Xiaoyan Li, Allison Keshishian, Keith Friend. Writing ± review & editing: Allison Keshishian, Melissa Hamilton, Ruslan Horblyuk, Kiran Gupta, Xuemei Luo

A Practical Model Evaluating Antiviral Cytokines by Natural Killer Cells in Treatment Naïve Patients with Chronic Hepatitis B Virus Infection

for Immunology and Immunotherapy and NIHR Biomedical Research Centre, University of Birmingham , Birmingham , United Kingdom. Xiaoyan Li, Xiaobo Guo andYurong Gu contributed mail.sysu.edu.cn) 4

Effect of intravenous immunoglobulin on the function of Treg cells derived from immunosuppressed mice with Pseudomonas aeruginosa pneumonia

Aim The present study aimed to investigate the effect of intravenous immunoglobulin (IVIG) on regulatory T (Treg) cells derived from immunosuppressed mice with Pseudomonas aeruginosa (PA) pneumonia. Methods A total of 108 BALB/c mice were randomly divided into the following groups: control group (Control), immunosuppressed group (IS), PA pneumonia group (PA), PA pneumonia in...

Oral administration of sunitinib malate for long-term survival of a patient with multiple lung metastases from renal leiomyosarcoma

Oral administration of sunitinib malate for long-term survival of a patient with multiple lung metastases from renal leiomyosarcoma Xiaoyan Li, Hongjun Gao, Chuanhao Tang, Xiaoqing Liu Department of

Risk of chemotherapy-induced febrile neutropenia with early discontinuation of pegfilgrastim prophylaxis in US clinical practice

research was provided by Amgen Inc. to Policy Analysis Inc. (PAI). Declaration of financial/other relationships Derek Weycker, Alex Kartashov, and Jacqueline Figueredo are employed by PAI. Xiaoyan Li, Rich

Genetic Diversity and Structure Analysis of Percocypris pingi (Cypriniformes: Cyprinidae): Implications for Conservation and Hatchery Release in the Yalong River

Percocypris pingi is a near threatened cyprinid species, which has suffered a dramatic decline due to anthropogenic factors. As one response to this decline, hatchery release for P. pingi has been conducted in the lower reaches of the Yalong River since 2012. To understand the conservation status of this species and the potential impact of the release of hatchery-reared fish, we...

Decreased complexity of glucose dynamics preceding the onset of diabetes in mice and rats

collaboration. Author Contributions Conceptualization: Zuliang Yao, Rumin Zhang, Nina Xiaoyan Li, Jonathan Connick, Manu Data curation: Xiaohua Douglas Zhang, David Pechter, Liming Yang, Xiaoli Ping, Zuliang ... Formal analysis: Xiaohua Douglas Zhang, David Pechter, Liming Yang, Zuliang Yao, Manu Investigation: Xiaoli Ping, Zuliang Yao, Rumin Zhang, Xiaolan Shen, Nina Xiaoyan Li, Jonathan Connick, Manu

The Effect of Subcutaneous Fat on Electrical Impedance Myography: Electrode Configuration and Multi-Frequency Analyses

This study investigates the impact of the subcutaneous fat layer (SFL) thickness on localized electrical impedance myography (EIM), as well as the effects of different current electrodes, varying in distance and direction, on EIM output. Twenty-three healthy subjects underwent localized multi-frequency EIM on their biceps brachii muscles with a hand-held electrode array. The EIM...

Mass spectrometry-based serum peptidome profiling accurately and reliably predicts outcomes of pemetrexed plus platinum chemotherapy in patients with advanced lung adenocarcinoma

Background Although pemetrexed plus cis/carboplatin has become the most effective chemotherapy regimen for patients with advanced lung adenocarcinoma, predictive biomarkers are not yet available, and new tools to identify chemosensitive patients who would likely benefit from this treatment are desperately needed. In this study, we constructed and validated predictive peptide...

Automatic diagnosis of imbalanced ophthalmic images using a cost-sensitive deep convolutional neural network

Ocular images play an essential role in ophthalmological diagnoses. Having an imbalanced dataset is an inevitable issue in automated ocular diseases diagnosis; the scarcity of positive samples always tends to result in the misdiagnosis of severe patients during the classification task. Exploring an effective computer-aided diagnostic method to deal with imbalanced...

Advanced lung adenocarcinoma with spinal cord metastasis successfully treated with second EGFR-TKI treatment: a case report and literature review

Advanced lung adenocarcinoma with spinal cord metastasis successfully treated with second EGFR-TKI treatment: a case report and literature review Xiaoyan Li, Hui Yang, Jing Zhao, Hongjun Gao

Fluid Intelligence and Automatic Neural Processes in Facial Expression Perception: An Event-Related Potential Study

The relationship between human fluid intelligence and social-emotional abilities has been a topic of considerable interest. The current study investigated whether adolescents with different intellectual levels had different automatic neural processing of facial expressions. Two groups of adolescent males were enrolled: a high IQ group and an average IQ group. Age and parental...