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Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair

This review summarizes current advances in dental pulp stem cells (DPSCs) and their potential applications in the nervous diseases. Injured adult mammalian nervous system has a limited regenerative capacity due to an insufficient pool of precursor cells in both central and peripheral nervous systems. Nerve growth is also constrained by inhibitory factors (associated with central...

The global Minmax k-means algorithm

The global k-means algorithm is an incremental approach to clustering that dynamically adds one cluster center at a time through a deterministic global search procedure from suitable initial positions, and employs k-means to minimize the sum of the intra-cluster variances. However the global k-means algorithm sometimes results singleton clusters and the initial positions...

A Study on the Convergence of Family Particle Swarm Optimization

The sociological concept of family has been introduced in the particle swarm optimization (PSO) and the family PSO (FPSO) has been proposed, in which the particle swarm consisted of different families, each family consisted of different members, and there were different constraint relationships between family members. To further study the sensitivity of FPSO to the control...

Metabolomics in Cancer Biomarker Research

Purpose of Review As a research tool for quantitative measurement of small molecule metabolites, metabolomics has been devoted to search for biomarkers that can be used for diagnosis and prognosis of malignant tumors. The purpose of this review is to summarize recent literatures on metabolomic-based cancer biomarker research and to discuss the current issues and challenges in the...

Effects of research complexity and competition on the incidence and growth of coauthorship in biomedicine

Background Investigations into the factors behind coauthorship growth in biomedical research have mostly focused on specific disciplines or journals, and have rarely controlled for factors in combination or considered changes in their effects over time. Observers often attribute the growth to the increasing complexity or competition (or both) of research practices, but few...

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model

curation: Mahnaz Janghorban, Derek Zachman, Colin J. Daniel, Anupriya Agarwal. Formal analysis: Mahnaz Janghorban, Ellen M. Langer, Xiaoyan Wang, Derek Zachman, Jody Hooper, Rosalie C. Sears. Funding ... acquisition: Rosalie C. Sears. Investigation: Mahnaz Janghorban, Rosalie C. Sears. Methodology: Mahnaz Janghorban, Xiaoyan Wang, Derek Zachman. Project administration: Mahnaz Janghorban. Resources: Mahnaz

The decreased expression of TIPE2 protein in the decidua of patients with missed abortion and possible significance

Missed abortion is a common occurrence for otherwise healthy women. Immunological factor is one of the most important reasons. Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) is a novel negative immune regulator related to several human diseases. However, the expression level and clinical significance of TIPE2 in missed abortion remain unclear. The expression of TIPE2...

Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer

Though androgen deprivation therapy is the standard treatment for prostate cancer (PCa), most patients would inevitably progress to castration-resistant prostate cancer (CRPC) which is the main cause of PCa death. Therefore, the identification of novel molecular mechanism regulating cancer progression and achievement of new insight into target therapy would be necessary for...

Elevated tumor-to-liver uptake ratio (TLR) from 18F–FDG-PET/CT predicts poor prognosis in stage IIA colorectal cancer following curative resection

medical physicians (Dr. Zhanwen Zhang & Dr. Xiaoyan Wang) with more than 10 years of clinical experience in colorectal cancer imaging. The physicians identified visible lesions with high tracer uptake and

Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats

) and the Fundamental research funds for the central Universities(KYZ201526). Author information Author notes Yuanlong Hou, Xiaoyan Wang and Jihui Ping contributed equally to this work ... Search for Xiaoyan Wang in:Nature Research journals • PubMed • Google Scholar Search for Jihui Ping in:Nature Research journals • PubMed • Google Scholar Search for Zhihai Lei in:Nature Research journals

The effects of kisspeptin-10 on serum metabolism and myocardium in rats

Kisspeptin is a peptide encoded by the Kiss 1 gene and is also called metastin. Previous studies have generally focused on several functions of this peptide, including metastasis, puberty, vasoconstriction and reproduction. However, few studies have focused on the cardiac functions of kisspeptin. In the present study, cardiac histomorphology was observed via TEM (transmission...

Selection of the Inducer for the Differentiation of Chicken Embryonic Stem Cells into Male Germ Cells In Vitro

Several inducers have been used to differentiate embryonic stem cells (ESCs) into male germ cells but the induction process has been inefficient. To solve the problem of low efficiency of inducer for ESCs differentiation into male germ cells, all-trans retinoic acid (ATRA), Am80(the retinoic acid receptor agonist), and estradiol (E2) was used to induce ESCs to differentiate into...

Infliximab enhances the therapeutic effects of 5-fluorouracil resulting in tumor regression in colon cancer

Xiaoyan Wang 0 1 0 h unan Key Laboratory of Nonresolving Inflammation and Cancer , Changsha, Hunan , People's Republic of China 1 Department of Gastroenterology, The Third Xiangya Hospital of central south

Inhibition of HIV Virus by Neutralizing Vhh Attached to Dual Functional Liposomes Encapsulating Dapivirine

Although highly active antiretroviral therapy (HAART) has greatly improved the life expectancy of HIV/AIDS patients, the treatment is not curative. It is a global challenge which fosters an urgent need to develop an effective drug or neutralizing antibody delivery approach for the prevention and treatment of this disease. Due to the low density of envelope spikes with restricted...

Mesalazine-induced eosinophilic pneumonia with bone marrow infiltration: a case report and literature review

Mesalazine-induced eosinophilic pneumonia with bone marrow infiltration: a case report and literature review Yunjian Zhang,1 Ling Luo,1 Xiaofang Wang,1 Xiaoyang Liu,1 Xiaoyan Wang,1 Yi Ding2

Spatially-Distributed Cost–Effectiveness Analysis Framework to Control Phosphorus from Agricultural Diffuse Pollution

Best management practices (BMPs) for agricultural diffuse pollution control are implemented at the field or small-watershed scale. However, the benefits of BMP implementation on receiving water quality at multiple spatial is an ongoing challenge. In this paper, we introduce an integrated approach that combines risk assessment (i.e., Phosphorus (P) index), model simulation...

Profit Allocation in Fuzzy Cooperative Games in Manufacturing and Logistics Industry

Purpose: Alliance between manufacturing and logistics industry is a new model of the joint development of the two industries. A reasonable profit allocation mechanism is the key to ensure the stable operation of the alliance, as well as to achieve the desired objectives. Based on uncertainty of alliance expected return as well as the inherent features of the alliance, this...

Validation of the Chinese version of the FOUR score in the assessment of neurosurgical patients with different level of consciousness

Background The Glasgow Coma Scale (GCS) is currently the most widely used scoring system for comatose patients. A decade ago, the Full Outline of Unresponsiveness (FOUR) score was devised to better capture four functional aspects of consciousness (eye, motor responses, brainstem reflexes, and respiration). This study aimed to validate the Chinese version of the FOUR score in...

Dynamical Analysis of a Plateau Pika with Cross-Diffusion under Contraception Control

2013; Published 18 February 2014 Academic Editor: Seenith Sivasundaram Copyright © 2014 Xiaoyan Wang et al. This is an open access article distributed under the Creative Commons Attribution License

RNA-Seq-Mediated Transcriptome Analysis of a Fiberless Mutant Cotton and Its Possible Origin Based on SNP Markers

As the longest known single-celled trichomes, cotton (Gossypium L.) fibers constitute a classic model system to investigate cell initiation and elongation. In this study, we used a high-throughput transcriptome sequencing technology to identify fiber-initiation-related single nucleotide polymorphism (SNP) markers and differentially expressed genes (DEGs) between the wild-type (WT...