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Liraglutide and Metformin alone or combined therapy for type 2 diabetes patients complicated with coronary artery disease

This study is to compare the effects of Liraglutide and Metformin alone or combined treatment on the cardiac function in T2DM patients complicated with CAD. 120 T2DM patients were included at Endocrinology Department of Tianjin First Center Hospital (Tianjin, China) from April 2012 to September 2013. The study contained two sections. Section 1: 30 patients in group 1 was treated ...

Integrating Cell Phones into a Chinese High School EFL Classroom: Students’ Attitudes, Technological Readiness, and Perceived Learning

-learning approach to a broader audience. Feihong Wang, Ph.D. Virginia Polytechnic Institute and State University Email: Xin Chen, Ph.D. Virginia Polytechnic Institute and State University Email: Weini

Aberrant baseline brain activity in psychogenic erectile dysfunction patients: a resting state fMRI study

Conflict of interest Chenwang Jin, Minghao Dong, Min Guan, Jia Wu, Zhen He, Xin Chen, Dapeng Shi, Junchan Ren, Guangming Shi, and Xiangsheng Zhang declared no conflict of interest. Ethical approval All

Treatment evaluation of Wharton’s jelly-derived mesenchymal stem cells using a chronic salpingitis model: an animal experiment

Background The present study was conducted to evaluate new methods to repair the reproductive function of the oviduct, thereby allowing gametes to combine and grow in vivo under natural circumstances. Methods Sixty pathogen-free female New Zealand rabbits were divided into three groups: a wild-type group, an untreated control group, and a treatment group. Disposable sterile newborn ...

Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents

Deubiquitinases (DUBs) play an important role in protein quality control in eukaryotic cells due to their ability to specifically remove ubiquitin from substrate proteins. Therefore, recent findings have focused on the relevance of DUBs to cancer development, and pharmacological intervention on these enzymes has become a promising strategy for cancer therapy. In particular, several ...

Prenatal Exposure to Lipopolysaccharide Induces PTX3 Expression and Results in Obesity in Mouse Offspring

: Shugang Qin, Xin Chen, and Meng Gao. Analyzed the data: Shugang Qin. Contributed reagents/materials/ analysis tools: Jianzhi Zhou and Xiaohui Li. Contributed to the writing of the manuscript: Shugang Qin

Converging and emerging threats to health security

Advances in biological sciences have outpaced regulatory and legal frameworks for biosecurity. Simultaneously, there has been a convergence of scientific disciplines such as synthetic biology, data science, advanced computing and many other technologies, which all have applications in health. For example, advances in cybercrime methods have created ransomware attacks on hospitals, ...

Backfilling behavior of a mixed aggregate based on construction waste and ultrafine tailings

To study the possibility of utilizing mixed construction waste and ultrafine tailings (CW&UT) as a backfilling aggregate that can be placed underground in a mine, physicochemical evaluation, proportioning strength tests, and pumpability experiments were conducted. It was revealed that mixed CW&UT can be used as a backfilling aggregate due to the complementarities of their ...

Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China

Human coronaviruses (HCoV) OC43, 229E, NL63, and HKU1 are common respiratory viruses which cause various respiratory diseases, including pneumonia. There is a paucity of evidence on the epidemiology and clinical manifestations of these four HCoV strains worldwide. We collected 11,399 throat swabs from hospitalized children with acute respiratory tract infection from July 2009 to ...

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

: Diego F. Calvisi, Xin Chen. Data curation: Jiaoyuan Jia, Yu Qiao, Maria G. Pilo, Antonio Cigliano, Xianqiong Liu, Zixuan Formal analysis: Jiaoyuan Jia, Yu Qiao, Diego F. Calvisi, Xin Chen. Funding ... acquisition: Xin Chen. Investigation: Jiaoyuan Jia, Yu Qiao, Maria G. Pilo, Antonio Cigliano, Xianqiong Liu, Zixuan Shao, Diego F. Calvisi, Xin Chen. Methodology: Jiaoyuan Jia, Yu Qiao, Maria G. Pilo

Effects of Bilayer Thickness on the Morphological, Optical, and Electrical Properties of Al2O3/ZnO Nanolaminates

This report mainly focuses on the investigation of morphological, optical, and electrical properties of Al2O3/ZnO nanolaminates regulated by varying bilayer thicknesses. The growth mechanism of nanolaminates based on atomic layer deposition and Al penetration into ZnO layer are proposed. The surface roughness of Al2O3/ZnO nanolaminates can be controlled due to the smooth effect of ...

Critical nodes identification in complex systems

performance metrics to B Xin Chen identify critical nodes in complex systems such as smart grid, social networks, information systems, and criminal organizations. For example, to protect an electrical power

A method for defensing against multi-source Sybil attacks in VANET

Sybil attack can counterfeit traffic scenario by sending false messages with multiple identities, which often causes traffic jams and even leads to vehicular accidents in vehicular ad hoc network (VANET). It is very difficult to be defended and detected, especially when it is launched by some conspired attackers using their legitimate identities. In this paper, we propose an event ...

Positive asymptotically almost periodic solutions for hematopoiesis model

By using the fixed point theory and Lyapunov functional, we establish the existence and stability of asymptotically almost periodic solution to hematopoiesis of the form x ′ ( t ) = − a ( t ) x ( t ) + ∑ i = 1 k b i ( t ) 1 + x n ( t − τ i ( t ) ) , t ∈ R . Unlike many previous related results, we do not assume the condition inf t ∈ R a ( t ) > 0 , which is a key assumption in ...

Better recognition, diagnosis and management of non-IgE-mediated cow’s milk allergy in infancy: iMAP—an international interpretation of the MAP (Milk Allergy in Primary Care) guideline

received lecture and consultancy fees from Nestle, Nutricia and Mead Johnson. Anna Nowak‑ Wegrzyn has received educational lecture fees from Mead Johnson, Nestle and Danone. Tong‑ Xin Chen has received has

Transcriptome analysis of hexaploid hulless oat in response to salinity stress

Background Oat is a cereal crop of global importance used for food, feed, and forage. Understanding salinity stress tolerance mechanisms in plants is an important step towards generating crop varieties that can cope with environmental stresses. To date, little is known about the salt tolerance of oat at the molecular level. To better understand the molecular mechanisms underlying ...

Effects of Defects on the Mechanical Properties of Kinked Silicon Nanowires

Kinked silicon nanowires (KSiNWs) have many special properties that make them attractive for a number of applications. The mechanical properties of KSiNWs play important roles in the performance of sensors. In this work, the effects of defects on the mechanical properties of KSiNWs are studied using molecular dynamics simulations and indirectly validated by experiments. It is found ...

Current computational transportation science

such as spatial human-computer interaction, network analysis, routing heuristics, and collaborative transportation and evacuation. Xin Chen is a Senior Engineering Manager and Research Scientist at HERE

A randomized controlled trial on effects of different hemostatic sponges in posterior spinal fusion surgeries

Background Spinal fusion surgery is associated with significant blood loss, which may result in potential clinical complications, it is necessary to take safe and effective measures to reduce blood loss in surgery. We perform this study to assess the impact of three different hemostatic materials on perioperative blood loss. Methods We performed a Randomized Controlled Trial ...