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Harbin 2020 R&D Personnel Demand Forecast Based on Manufacturing Green Innovation System

Because of the constraints of energy conservation and the impact on the environment, the manufacturing industry has adopted sustainable development as the goal, and a green manufacturing innovation system based on environmental protection has emerged. In order to provide R&D personnel support to manufacturing enterprises in Harbin, and in order to promote the construction of a...

Harbin 2020 R&D Personnel Demand Forecast Based on Manufacturing Green Innovation System

Because of the constraints of energy conservation and the impact on the environment, the manufacturing industry has adopted sustainable development as the goal, and a green manufacturing innovation system based on environmental protection has emerged. In order to provide R&D personnel support to manufacturing enterprises in Harbin, and in order to promote the construction of a...

Effect of long-term fertilization strategies on bacterial community composition in a 35-year field experiment of Chinese Mollisols

Bacteria play vital roles in soil biological fertility; however, it remains poorly understood about their response to long-term fertilization in Chinese Mollisols, especially when organic manure is substituted for inorganic nitrogen (N) fertilizer. To broaden our knowledge, high-throughput pyrosequencing and quantitative PCR were used to explore the impacts of inorganic...

Molecular characterization of mudskipper (Boleophthalmus pectinirostris) hypoxia-inducible factor-1α (HIF-1α) and analysis of its function in monocytes/macrophages

Hypoxia-inducible factor-1α (HIF-1α) plays a critical role in immune and inflammatory responses and is important in controlling a variety of processes in monocytes and macrophages. However, very little information is available about the functions of HIF-1α in fish monocytes/macrophages (MO/MФ). In this study, the cDNA sequence of the mudskipper (Boleophthalmus pectinirostris) HIF...

The clinical efficacy and safety evaluation of ticagrelor for acute coronary syndrome in general ACS patients and diabetic patients: A systematic review and meta-analysis

Objective In this study, a systematic evaluation was conducted to estimate the efficacy and safety of ticagrelor for treating acute coronary syndrome (ACS) in general ACS patients and a diabetes mellitus (DM) group. Methods A search of PubMed, Cochrane Central Register of Controlled Trials, Web of Science, CNKI databases was conducted to analyze relevant randomized controlled...

Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse

Wei-Guang Wang Xin Jiang 0 Xuan Wen Kai-Jin Hu 0 Yang Xue 0 0 State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases &Shaanxi Clinical Research Center for

Energy-efficient control of a screw-drive pipe robot with consideration of actuator’s characteristics

Pipe robots can perform inspection tasks to alleviate the damage caused by the pipe problems. Usually, the pipe robots carry batteries or use a power cable draining power from a vehicle that has many equipments for exploration. Nevertheless, the energy is limited for the whole inspection task and cannot keep the inspection time too long. In this paper, we use the total input...

Granulocyte colony-stimulating factor blockade enables dexamethasone to inhibit lipopolysaccharide-induced murine lung neutrophils

Glucocorticoids promote neutrophilic inflammation, the mechanisms of which are poorly characterized. Using a lipopolysaccharide (LPS)-induced acute murine lung injury model, we determined the role of granulocyte colony-stimulating factor (G-CSF) in mouse lung neutrophil numbers in the absence and presence of dexamethasone, a potent glucocorticoid. G-CSF was blocked using a...

A preliminary study of skin ultrasound in diffuse cutaneous systemic sclerosis: Does skin echogenicity matter?

Objective To evaluate the usefulness of skin ultrasound and acoustic radiation force impulse (ARFI) quantification in diffuse cutaneous systemic sclerosis (dcSSc). Patients and methods 28 patients with dcSSc, and 15 age gender matched normal controls were recruited. Skin echogenicity, thickness, and ARFI quantification were measured by ultrasound at 17 sites corresponding to the...

Molecular Characterization of E-Type Prostanoid Receptor 4 (EP4) from Ayu (Plecoglossus altivelis) and Its Functional Analysis in the Monocytes/Macrophages

Prostaglandin E2 (PGE2) plays an important role in a broad spectrum of physiological and pathological processes by interacting with E-type prostanoid receptors (EPs). EP4 is one of four EP subtypes known to mediate the immune response in mammalian monocytes/macrophages. However, the precise function and characteristics of EP4 in fish remain unclear. In this study, we...

The Role of Node Heterogeneity in the Coupled Spreading of Epidemics and Awareness

Exploring the interplay between information spreading and epidemic spreading is a topic that has been receiving increasing attention. As an efficient means of depicting the spreading of information, which manifests as a cascade phenomenon, awareness cascading is utilized to investigate this coupled transmission. Because in reality, different individuals facing the same epidemic...

Microstructures and properties of rapidly solidified Cu90Zr10-x Al x alloys

Cu90Zr10-x Al x (x=1, 3, 5, 7, 9; at.%) alloy rods were synthesized based on rapid solidification method. The structure, distribution of elements, mechanical properties and electrical conductivity of the Cu-based alloy samples were studied using X-ray diffraction (XRD), scanning electron microscope (SEM), electro-probe micro-analyzer (EPMA), uniaxial compression test and four...

The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury

Background Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. Methods Based on the fact that postnatal regeneration of alveolar tissue has been attributed to alveolar epithelial cells, we established a hemorrhagic shock and Lipopolysaccharide (LPS) lung injury model...

The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury

Background Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. Methods Based on the fact that postnatal regeneration of alveolar tissue has been attributed to alveolar epithelial cells, we established a hemorrhagic shock and Lipopolysaccharide (LPS) lung injury model...

Effect of surface roughness on sliding friction of micron-sized glass beads

In order to understand the contact phenomena of micron-sized particles, which have a tremendous impact on a variety of applications in industry and technology, direct access to the loads as well as the displacements accompanying such contacts are mandatory. Typical particle ensembles show a size variation ranging from the nanometer to the tenths of micron scale. Especially the...

Root iTRAQ protein profile analysis of two Citrus species differing in aluminum-tolerance in response to long-term aluminum-toxicity

Background Limited information is available on aluminum (Al)-toxicity-responsive proteins in woody plant roots. Seedlings of ‘Xuegan’ (Citrus sinensis) and ‘Sour pummelo’ (Citrus grandis) were treated for 18 weeks with nutrient solution containing 0 (control) or 1.2 mM AlCl 3  · 6H 2 O (+Al). Thereafter, we investigated Citrus root protein profiles using isobaric tags for...

Uropathogenic E.coli (UPEC) Infection Induces Proliferation through Enhancer of Zeste Homologue 2 (EZH2)

Host-pathogen interactions can induce epigenetic changes in the host directly, as well as indirectly through secreted factors. Previously, uropathogenic Escherichia coli (UPEC) was shown to increase DNA methyltransferase activity and expression, which was associated with methylation-dependent alterations in the urothelial expression of CDKN2A. Here, we showed that paracrine...

Mesenchymal Stem Cells Stabilize Atherosclerotic Vulnerable Plaque by Anti-Inflammatory Properties

Background and objectives Formation and progression of atherosclerotic vulnerable plaque (VP) is the primary cause of many cardio-cerebrovascular diseases such as acute coronary syndrome and stroke. It has been reported that bone marrow mesenchymal stem cells (MSC) exhibit protective effects against many kinds of diseases including myocardial infarction. Here, we examined the...