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23 papers found.
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Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation

Xing Zhu 0 Han Seul Ryu 0 Christopher R. Jacobs 0 0 Columbia University Department of Biomedical Engineering , 500 W 120th St, New York, NY 10027 , USA Background: The fully developed adult skeleton

Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate

structure reveals a key intermediate on the path to establishing the global architecture of 60S subunits. ribosome assembly; cryo-EM; pre-60S ribosome; nucleolar - Dejian Zhou and Xing Zhu have contributed ... spectral abundance factor; SCPHR, spectral counts per 100 residues; SSU, small subunit; TAP, tandem affinity purification. COMPLIANCE WITH ETHICS GUIDELINES Dejian Zhou, Xing Zhu, Sanduo Zheng, Dan Tan

Differential distributions for t-channel single top-quark production and decay at next-to-next-to-leading order in QCD

We present a detailed phenomenological study of the next-to-next-to-leading order (NNLO) QCD corrections for t-channel single top (anti-)quark production and its semi-leptonic decay at the CERN Large Hadron Collider (LHC). We find the NNLO corrections for the total inclusive rates at the LHC with different center of mass energies are generally smaller than the NLO corrections...

Light quark Yukawa couplings from Higgs kinematics

We show that the normalized Higgs production p T and y h distributions are sensitive probes of Higgs couplings to light quarks. For up and/or down quark Yukawa couplings comparable to the SM b quark Yukawa the ūu or \( \overline{d}d \) fusion production of the Higgs could lead to appreciable softer p T distribution than in the SM. The rapidity distribution, on the other hand...

The Effect of Intravenous Immunoglobulin Combined with Corticosteroid on the Progression of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Meta-Analysis

Background Intravenous immunoglobulin (IVIG) treatment is commonly used to treat Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with controversial therapeutic effect. Methods We conducted a comprehensive meta-analysis through combining the published eligible studies to evaluate the effectiveness of IVIG on SJS and TEN treatment. Results A total of 26 studies...

Diphoton excess at 750 GeV: gluon–gluon fusion or quark–antiquark annihilation?

Recently, ATLAS and CMS collaborations reported an excess in the measurement of diphoton events, which can be explained by a new resonance with a mass around 750 GeV. In this work, we explored the possibility of identifying if the hypothetical new resonance is produced through gluon–gluon fusion or quark–antiquark annihilation, or tagging the beam. Three different observables for...

CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma

Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for approximately 80–90% of all primary kidney cancer. Treatment for patients with advanced RCC remains unsatisfactory. Rare cancer stem cells (CSCs) are proposed to be responsible for failure of current treatment. OncoLnc was used as a tool for interactively exploring survival correlations. Gene manipulation...

On the calculation of soft phase space integral

The recent discovery of the Higgs boson at the LHC attracts much attention to the precise calculation of its production cross section in quantum chromodynamics. In this work, we discuss the calculation of soft triple-emission phase space integral, which is an essential ingredient in the recently calculated soft-virtual corrections to Higgs boson production at next-to-next-to-next...

Cmr4 is the slicer in the RNA-targeting Cmr CRISPR complex

Clustered regularly interspaced short palindromic repeat (CRISPR) loci and CRISPR-associated (Cas) proteins form an adaptive immune system that protects prokaryotes against plasmids and viruses. The Cmr complex, a type III-B effector complex, uses the CRISPR RNA (crRNA) as a guide to target RNA. Here, we show that the Cmr complex of Pyrococcus furiosus cleaves RNA at multiple...

Computational explanation for bioactivation mechanism of targeted anticancer agents mediated by cytochrome P450s: A case of Erlotinib

EGFR inhibitors, even with therapeutics superiorities in anticancer, can cause idiosyncratic pulmonary and hepatic toxicities that are associated with the reactive electrophile bioactivated by Cytochrome P450s (P450s). Until now, neither has the electrophilic intermediate been caught experimentally, nor has the subtle mechanism been declared. Herein, the underlying mechanism of...

Single soft gluon emission at two loops

Ye Li 0 Hua Xing Zhu 0 0 SLAC National Accelerator Laboratory, Stanford University , Stanford, CA 94309, U.S.A We study the single soft-gluon current at two loops with two energetic partons in

The iatrogenic injury of double vena cava due to misdiagnosis during the radical nephroureterectomy and cystectomy

Double inferior vena cava (d-IVC) is a subtype of vascular anomaly that rarely needs treatment. Here, we present a rare case of d-IVC accompanied with concurrent renal pelvis and bladder carcinoma. Due to misdiagnosis, the anomalous left inferior vena cava (IVC) entering the left renal vein was mistaken as the gonadal vein and was then severed during the radical...

Nesterov’s Smoothing and Excessive Gap Methods for an Optimization Problem in VLSI Placement

Jian-Li Chen 0 Yan Cui 0 Wen-Xing Zhu 0 0 J.-L. Chen Y. Cui W.-X. Zhu (&) Center for Discrete Mathematics and Theoretical Computer Science, Fuzhou University , Fuzhou 350108 , China In this paper

Successful cloning of an adult breeding boar from the novel Chinese Guike No. 1 swine specialized strain

Somatic cloning, also known as somatic cell nuclear transfer (SCNT), is a promising technology which has been expected to rapidly extend the population of elaborately selected breeding boars with superior production performance. Chinese Guike No. 1 pig breed is a novel swine specialized strain incorporated with the pedigree background of Duroc and Chinese Luchuan pig breeds, thus...

The complete two-loop integrated jet thrust distribution in soft-collinear effective theory

In this work, we complete the calculation of the soft part of the two-loop integrated jet thrust distribution in e + e − annihilation. This jet mass observable is based on the thrust cone jet algorithm, which involves a veto scale for out-of-jet radiation. The previously uncomputed part of our result depends in a complicated way on the jet cone size, r, and at intermediate stages...

Arg-Gly-Asp (RGD)-Modified E1A/E1B Double Mutant Adenovirus Enhances Antitumor Activity in Prostate Cancer Cells In Vitro and in Mice

CAR is a transmembrane protein that is expressed in various epithelial and endothelial cells. CAR mediates adenoviral infection, as well as adenovirus-mediated oncolysis of AxdAdB-3, an E1A/E1B double-restricted oncolytic adenovirus, in prostate cancer cells. This study further assessed the therapeutic efficacy of AxdAdB-3 with Arg-Gly-Asp (RGD)-fiber modification (AxdAdB3-F/RGD...

eEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial Cells

Objective We investigated whether glutamate, NMDA receptors, and eukaryote elongation factor-2 kinase (eEF-2K)/eEF-2 regulate P-glycoprotein expression, and the effects of the eEF-2K inhibitor NH125 on the expression of P-glycoprotein in rat brain microvessel endothelial cells (RBMECs). Methods Cortex was obtained from newborn Wistar rat brains. After surface vessels and meninges...

Primary ectopic atypical meningioma in the renal hilum: a case report

Background Primary ectopic atypical meningioma involving the renal hilum is rare. This is, to our knowledge, only the second case report of a primary retroperitoneal meningioma and the first case of an atypical subtype in this location. Case presentation A 53-year-old Han Chinese man presented with a 2-year history of left-side flank pain. An oval-shaped retroperitoneal mass was...

Apoptosis of THP-1 Derived Macrophages Induced by Sonodynamic Therapy Using a New Sonosensitizer Hydroxyl Acetylated Curcumin

Curcumin is extracted from the rhizomes of the traditional Chinese herb Curcuma longa. Our previous study indicated curcumin was able to function as a sonosensitizer. Hydroxyl acylated curcumin was synthesized from curcumin to eliminate the unstable hydroxy perssad in our group. The potential use of Hydroxyl acylated curcumin as a sonosensitizer for sonodynamic therapy (SDT...

Precise QCD predictions on top quark pair production mediated by massive color-octet vector boson at hadron colliders

We present a theoretical framework for systematically calculating next-to-leading order (NLO) QCD effects to various experimental observables in models with massive COVB in a model independent way at hadron colliders. Specifically, we show the numerical results for the NLO QCD corrections to total cross sections, invariant mass distribution and A FB of top quark pairs production...