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An Algorithm for the Mixed Transportation Network Design Problem

This paper proposes an optimization algorithm, the dimension-down iterative algorithm (DDIA), for solving a mixed transportation network design problem (MNDP), which is generally expressed as a mathematical programming with equilibrium constraint (MPEC). The upper level of the MNDP aims to optimize the network performance via both the expansion of the existing links and the...

Change in the immune function of porcine iliac artery endothelial cells infected with porcine circovirus type 2 and its inhibition on monocyte derived dendritic cells maturation

assistance with flow cytometry analysis. Author Contributions Data curation: Ning Yang, Jinzeng Qiao, Shiyu Liu, Xinyu Liu. Formal analysis: Ning Yang, Shiyu Liu. Funding acquisition: Shuanghai Zhou

Microstructures and microwave dielectric properties of (Ba1−x Sr x )4(Sm0.4Nd0.6)28/3Ti18O54 solid solutions

(Ba1−x Sr x )4(Sm0.4Nd0.6)28/3Ti18O54 (x = 0.02, 0.04, 0.06, 0.08, 0.1) solid solutions were prepared by the conventional solid-state reaction process. It was found that (Ba1−x Sr x )4(Sm0.4Nd0.6)28/3Ti18O54 ceramics are fully composed of BaSm2Ti4O12 and BaNd2Ti5O14 phases for all the compositions. The increasing x value (0.02 ≤ x ≤ 0.1) in ((Ba1−x Sr x )4(Sm0.4Nd0.6)28/3Ti18O54...

Altered expression profiles of microRNA families during de-etiolation of maize and rice leaves

Background MicroRNAs (miRNAs) are highly conserved small non-coding RNAs that play important regulatory roles in plants. Although many miRNA families are sequentially and functionally conserved across plant kingdoms (Dezulian et al. in Genome Biol 13, 2005), they still differ in many aspects such as family size, average length, genomic loci etc. (Unver et al. in Int J Plant...

Identifying Multi-Dimensional Co-Clusters in Tensors Based on Hyperplane Detection in Singular Vector Spaces

Co-clustering, often called biclustering for two-dimensional data, has found many applications, such as gene expression data analysis and text mining. Nowadays, a variety of multi-dimensional arrays (tensors) frequently occur in data analysis tasks, and co-clustering techniques play a key role in dealing with such datasets. Co-clusters represent coherent patterns and exhibit...

Enhanced energy storage properties of Bi0.5Li0.5TiO3 modified Sr0.1Bi0.45Na0.45TiO3 based ceramics

Lead-free (1−x)Sr0.1Bi0.45Na0.45TiO3−xBi0.5Li0.5TiO3 (x = 0−0.4) ceramics were successfully prepared by a solid-state reaction technique. The effects of amount of Bi0.5Li0.5TiO3 on structure and electrical properties were examined. The X-ray diffraction (XRD) analysis revealed that all the investigated specimens have a perovskite structure. An obvious change in microstructure...

Glycoside Hydrolase MoGls2 Controls Asexual/Sexual Development, Cell Wall Integrity and Infectious Growth in the Rice Blast Fungus

N-linked glycosylation is a way of glycosylation for newly synthesized protein, which plays a key role in the maturation and transport of proteins. Glycoside hydrolases (GHs) are essential in this process, and are involved in processing of N-linked glycoproteins or degradation of carbohydrate structures. Here, we identified and characterized MoGls2 in Magnaporthe oryzae, which is...

Modeling of Mechanical Stress Exerted by Cholesterol Crystallization on Atherosclerotic Plaques

Plaque rupture is the critical cause of cardiovascular thrombosis, but the detailed mechanisms are not fully understood. Recent studies have found abundant cholesterol crystals in ruptured plaques, and it has been proposed that the rapid expansion of cholesterol crystals in a limited space during crystallization may contribute to plaque rupture. To evaluate the effect of...

High Level Expression and Purification of Recombinant Proteins from Escherichia coli with AK-TAG

Adenylate kinase (AK) from Escherichia coli was used as both solubility and affinity tag for recombinant protein production. When fused to the N-terminus of a target protein, an AK fusion protein could be expressed in soluble form and purified to near homogeneity in a single step from Blue-Sepherose via affinity elution with micromolar concentration of P1, P5- di (adenosine—5...

Determination of sample size for a multi-class classifier based on single-nucleotide polymorphisms: a volume under the surface approach

Background Data on single-nucleotide polymorphisms (SNPs) have been found to be useful in predicting phenotypes ranging from an individual’s class membership to his/her risk of developing a disease. In multi-class classification scenarios, clinical samples are often limited due to cost constraints, making it necessary to determine the sample size needed to build an accurate...

Immunohistochemical Study of Expression of Sohlh1 and Sohlh2 in Normal Adult Human Tissues

The expression pattern of Sohlh1 (spermatogenesis and oogenesis specific basic helix-loop-helix 1) and Sohlh2 in mice has been reported in previous studies. Sohlh1 and Sohlh2 are specifically expressed in spermatogonia, prespermatogonia in male mice and oocytes of primordial and primary follicles in female mice. In this report, we studied the expression pattern of Sohlh1 and...

MoMyb1 is required for asexual development and tissue-specific infection in the rice blast fungus Magnaporthe oryzae

Background The Myb super-family of proteins contain a group of functionally diverse transcriptional activators found in plant, animal and fungus. Myb proteins are involved in cell proliferation, differentiation and apoptosis, and have crucial roles in telomeres. The purpose of this study was to characterize the biological function of Myb1 protein in the rice blast fungus...

Association between Lipid Ratios and Insulin Resistance in a Chinese Population

Aim To explore the association of lipid ratios and triglyceride (TG) with insulin resistance (IR) in a Chinese population. We also provide the clinical utility of lipid ratios to identify men and women with IR. Methods This cross-sectional study included 614 men and 1055 women without diabetes. Insulin resistance was defined by homeostatic model assessment of IR > 2.69. Lipid...

Dramatic early event in chronic allograft nephropathy: increased but not decreased expression of MMP-9 gene

Objective The infiltration of mononuclear cells and replication and migration of smooth muscle cells (SMCs) from media into the intima in the vascular wall are the cardinal pathological changes in the early stage of chronic allograft nephropathy (CAN). But the mechanism is unclear. Therefore we investigated the role of matrix metalloproteinase 9 (MMP-9) and its interaction with...

Broad-band direct QPSK modulator/demodulator for wireless gigabit communication

The design and measured results of a broad-band direct quadrature phase shift keying (QPSK) modulator and demodulator are described in this paper. The circuits are fabricated using 1-μm GaAs HBT technology. To suppress the local oscillator (LO) leakage, the double-balanced mixer is selected as the core unit in the modulator/demodulator. An embedded four-way quadrature divider...

Methylthioadenosine Reprograms Macrophage Activation through Adenosine Receptor Stimulation

Regulation of inflammation is necessary to balance sufficient pathogen clearance with excessive tissue damage. Central to regulating inflammation is the switch from a pro-inflammatory pathway to an anti-inflammatory pathway. Macrophages are well-positioned to initiate this switch, and as such are the target of multiple therapeutics. One such potential therapeutic is...

Sample size determination for classifiers based on single-nucleotide polymorphisms

, GA 30602 , USA 2 XINYU LIU Department of Statistics, University of Georgia , Athens, GA 30602 , USA 3 Department of Statistics, University of Georgia , Athens, GA 30602 , USA c The Author 2012

Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity

Background Co-Activator Arginine Methyltransferase 1(CARM1) is an Estrogen Receptor (ER) cofactor that remodels chromatin for gene regulation via methylation of Histone3. We investigated CARM1 levels and localization across breast cancer tumors in a cohort of patients of either European or African ancestry. Methods We analyzed CARM1 levels using tissue microarrays with over 800...