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Prognostic significance of cytokeratin 19 expression in pancreatic neuroendocrine tumor: A meta-analysis

clinicopathology. CK-19 can predict the prognosis of PNET patients. Supporting information S1 File. PRISMA checklist. (DOC) Author Contributions Conceptualization: Xiujun Cai. Formal analysis: Xiujun Cai

The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy

The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy Xu Feng,1,* Kelei Zhu,1,2,* Jinghua Liu,1 Jiang Chen,1 Jiacheng Tang,3 Yuelong Liang,1 Renan Jin,1 Xiao Liang,1 Xiujun Cai1,3 1Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou...

Cyclin B1 Suppresses Colorectal Cancer Invasion and Metastasis by Regulating E-Cadherin

Cyclin B1, a mitotic cyclin, has been implicated in malignances. However, its contribution to colorectal cancer invasion and metastasis are still not well understood. Here, we demonstrated that the invasion and metastasis of colorectal cancer is regulated by Cyclin B1. Overexpression of Cyclin B1 was observed in colorectal cancer tissues, but this elevated expression was...

Role of estrogen in hepatocellular carcinoma: is inflammation the key?

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and accounts for the third-leading cause of cancer-related deaths. Over the past decades, advances have been made in the field of surgery, but effective treatment of HCC is lacking. Due to a marked male predominance in morbidity and mortality in HCC patients, it has long been considered that sex...

Prognostic Significance of E-Cadherin Expression in Hepatocellular Carcinoma: A Meta-Analysis

Backgrounds Hepatocellular Carcinoma (HCC) is one of the most common malignancy of liver and HCC-related morbidity and mortality remains at high level. Researchers had investigated whether and how reduced E-cadherin expression impacted the prognosis of patients with HCC but the results reported by different teams remain inconclusive. Methods A systematic literature search was...

Cytoplasmic and/or Nuclear Expression of β-Catenin Correlate with Poor Prognosis and Unfavorable Clinicopathological Factors in Hepatocellular Carcinoma: A Meta-Analysis

Background The β-catenin is an important effector in WNT/β-catenin signaling pathway, which exerts a crucial role in the development and progression of hepatocellular carcinoma (HCC). Some researchers have suggested that the overexpression of β-catenin in cytoplasm and/or nucleus was closely correlated to metastasis, poor differentiation and malignant phenotype of HCC while some...

Laparoscopic liver resection and the learning curve: a 14-year, single-center experience

procedures, respectively. We hope that this technique will increase in popularity. Disclosures Xiujun Cai, Zheyong Li, Yale Zhang, Hong Yu, Xiao Liang, Renan Jin, and Feng Luo have no conflicts of interest or

Polymorphisms of CD44 gene and nasopharyngeal carcinoma susceptibility in a Chinese population

As members of adhesion molecule families, CD44 transmembrane glycoproteins have been originally thought to be essential for the formation of multicellular organisms and soon recognised to be able to initiate metastatic spread of tumour cells. To investigate the association between CD44 polymorphisms and nasopharyngeal carcinoma (NPC), we carried out a two-stage case–control study...