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Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties

Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties Rui Wang,1,* Yang Li,2,* Xu-Dong Huai,3 Qing-Xuan Zheng,1 Wei Wang,1 Hui-Jing Li,4 Qi-Yong Huai1 ... medical research O r i g i n a l r e s e a r c h rui Wang 1,* Yang li 2,* Xu-Dong huai 3 *These authors contributed equally to this work Introduction Cancer is the world’s main public health problem

Leakage and Stiffness Characteristics of Bionic Cluster Spiral Groove Dry Gas Seal

‑mail: . XuDong Peng, born in 1964, is currently a professor at Zhejiang University of Technology, China. He received his PhD degree from Xi’an Jiaotong University, China, in 1999. His research

Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase

of labor, the RNA- RNA modification; N6-methyladenosine; METTL3; target recognition domain; zinc finger; paramagnetic relaxation enhancement - Jinbo Huang, Xu Dong and Zhou Gong have contributed ... ; ZFD, zinc finger domain. COMPLIANCE WITH ETHICS GUIDELINES Jinbo Huang, Xu Dong, Zhou Gong, Ling-Yun Qin, Shuai Yang, YueLing Zhu, Xiang Wang, Delin Zhang, Tingting Zou, Ping Yin and Chun Tang declare

Protocol for analyzing protein ensemble structures from chemical cross-links using DynaXL

Chemical cross-linking coupled with mass spectroscopy (CXMS) is a powerful technique for investigating protein structures. CXMS has been mostly used to characterize the predominant structure for a protein, whereas cross-links incompatible with a unique structure of a protein or a protein complex are often discarded. We have recently shown that the so-called over-length cross...

Structure of Micro-nano WC-10Co4Cr Coating and Cavitation Erosion Resistance in NaCl Solution

Cavitation erosion (CE) is the predominant cause for the failure of overflow components in fluid machinery. Advanced coatings have provided an effective solution to cavitation erosion due to the rapid development of surface engineering techniques. However, the influence of coating structures on CE resistance has not been systematically studied. To better understand their...

Blocking of stromal interaction molecule 1 expression influence cell proliferation and promote cell apoptosis in vitro and inhibit tumor growth in vivo in head and neck squamous cell carcinoma

Calcium signal plays an important role in a variety of cancer cell metabolism, but knowledge on its role in head and neck squamous cell carcinoma (HNSCC) is limited. Store-operated calcium entry (SOCE) is the principal Ca2+ entry mechanism that maintains calcium concentration and produces calcium signal in non-excitable cells. SOCE is triggered by stromal interaction molecule 1...

In Situ Analysis of Oxygen Vacancies and Band Alignment in HfO2/TiN Structure for CMOS Applications

The density of oxygen vacancies characterization in high-k/metal gate is significant for semiconductor device fabrication. In this work, a new approach was demonstrated to detect the density of oxygen vacancies by in situ x-ray photoelectron spectroscopy (XPS) and ultraviolet photoelectron spectroscopy (UPS) measurement. Moreover, the band alignment of the structure with optical...

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3# and GITC-18...

Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines

Background Epithelial to mesenchymal transition is a process in which a cell experiences a loss of epithelial cell characteristics and acquires a more mesenchymal cell phenotype. In cancer, epithelial to mesenchymal transition has been proposed to play an important role during specific stages of tumor progression. The role epithelial to mesenchymal transition and mesenchymal to...

Experimental Study on the Curing Effect of Dredged Sediments with Three Types of Curing Agents

Sediment solidification technology is widely used to dispose dredged sediment, three types of curing agents were used in this study to solidified the dredged sediment from shallows in Nantong with three types of curing agents: JY, ZL and FJ. The results showed that the optimal additive amounts of these three curing agents were 140g JY, 16g ZL, 2.0g FJ per 1000g of the dredged...

The Applications of Current Comparators in the Measurements on High Voltage Insulation

This paper describes the basic structure of the current comparator used for high voltage insulation measurements. Further applications for the current comparator in high voltage insulation are investigated and developed. A measuring system for the measurement of harmonics in the loss current of water tree aged insulation is described, as well as the principles to measure partial...

Performance of carbon fiber reinforced rubber composite armour against shaped charge jet penetration

, Explosives, Pyrotechnics, Online, DOI:10.1002/prep.201200172, ( 2013 ) 6. Xin Jia , Zheng-xiang Huang, Xu-dong Zu, Xiao-hui Gu, Chuan-sheng Zhu, Zhong-wen Zhang. Experimental study on the performance of woven

NPs/NPRs Signaling Pathways May Be Involved in Depression-Induced Loss of Gastric ICC by Decreasing the Production of mSCF

It is well known that natriuretic peptides (NPs) are involved in the regulation of gastrointestinal motility. Interstitial cells of Cajal (ICC) are the pacemaker cells of gastrointestinal motility and gastrointestinal dyskinesia is one of the important digestive tract symptoms of depression. However, it is unclear whether they are involved in depression-induced loss of ICC. The...

Use of modified lateral upper arm free flap for reconstruction of soft tissue defect after resection of oral cancer

Background To evaluate the suitability of a modified lateral upper arm free flap (LAFF) for reconstruction of soft tissue defects after resection of oral cancer. Methods Eighteen cases of soft tissue defect repair performed between January 2011 and December 2013 using a modified LAFF after resection of oral cancer were reviewed. The design and harvest of the LAFF, the...

Echocardiographic Evaluation of Changes in Cardiac Hemodynamics and Loading Conditions after Transthoracic Minimally Invasive Device Closure of Atrial Septal Defect

Purpose To evaluate transthoracic minimally invasive device closure of atrial septal defects by performing transthoracic echocardiography to measure changes in cardiac hemodynamics and loading conditions. Methods Between January 2012 and December 2012, we performed transthoracic minimally invasive device closure of atrial septal defects in 95 patients with secundum atrial septal...

Visualizing the Ensemble Structures of Protein Complexes Using Chemical Cross-Linking Coupled with Mass Spectrometry

, Yue-He Ding, Xu Dong, Na Liu, E. Erquan Zhang, Meng-Qiu Dong, and Chun Tang declare that they have no conflict of interest. Human and Animal Rights and Informed Consent This article does not contain

Inorganic cesium lead halide CsPbX3 nanowires for long-term stable solar cells

ABX3-type organic-inorganic hybrid halide perovskite materials have been recognized as promising candidates for optoelectronic applications. However, poor stability of organic-inorganic hybrid perovskite hinders their forward long-term utilization and hence an effective strategy is needed to replace the organic part with an inorganic cation. Herein, all inorganic CsPbI3 nanowires...

Treatment of complicated urinary tract infection and acute pyelonephritis by short-course intravenous levofloxacin (750 mg/day) or conventional intravenous/oral levofloxacin (500 mg/day): prospective, open-label, randomized, controlled, multicenter, non-inferiority clinical trial

Objective To compare the efficacy and safety of short-course intravenous levofloxacin (LVFX) 750 mg with a conventional intravenous/oral regimen of LVFX 500 mg in patients from China with complicated urinary tract infections (cUTIs) and acute pyelonephritis (APN). Methods This was a prospective, open-label, randomized, controlled, multicenter, non-inferiority clinical trial...