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MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB

Conceptualization: Xufeng Chen, Xu Zhang. Data curation: Shaoxi Niu. Formal analysis: Shaoxi Niu. Funding acquisition: Xin Ma. Methodology: Yu Zhang. Project administration: Xu Zhang. Resources: Xu Zhang

Developing novel methods to image and visualize 3D genomes

To investigate three-dimensional (3D) genome organization in prokaryotic and eukaryotic cells, three main strategies are employed, namely nuclear proximity ligation-based methods, imaging tools (such as fluorescence in situ hybridization (FISH) and its derivatives), and computational/visualization methods. Proximity ligation-based methods are based on digestion and re-ligation of...

Regioselective semi-synthesis of 6-isomers of 5,8-O-dimethyl ether of shikonin derivatives via an ‘intramolecular ring-closing/ring-opening’ strategy as potent anticancer agents

anticancer agents Li Zhou 2 Xu Zhang 1 Wen Zhou 0 0 School of Chinese Meteria Medica, Guangzhou University of Chinese Medicine, E. 232, University Town , Waihuan Rd, Panyu, Guangzhou 510006, Guangdong

Circular RNAs: emerging cancer biomarkers and targets

CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested to regulate gene expression at transcriptional, post-transcriptional, and translational levels. An increasing number of studies have shown that circRNAs play important roles...

New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD)

; VLDL, very low-density lipoprotein. COMPLIANCE WITH ETHICS GUIDELINES Xu Zhang, Xuetao Ji, Qian Wang, and John Zhong LI declare that they have no conflict of interest. This article does not contain any

Gastric precancerous diseases classification using CNN with a concise model

. Author Contributions Conceptualization: Jiquan Liu. Data curation: Weiling Hu, Fei Chen, Liangjing Wang. 8 / 10 Funding acquisition: Jiquan Liu. Investigation: Xu Zhang, Weiling Hu, Fei Chen ... . Methodology: Xu Zhang, Jiquan Liu, Yuanhang Yang. Project administration: Jiquan Liu. Resources: Weiling Hu, Fei Chen. Software: Xu Zhang, Yuanhang Yang. Supervision: Weiling Hu, Jiquan Liu, Liangjing Wang

Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis

Different physical and chemical stimuli are detected by the peripheral sensory receptors of dorsal root ganglion (DRG) neurons, and the generated inputs are transmitted via afferent fibers into the central nervous system. The gene expression profiles of DRG neurons contribute to the generation, transmission, and regulation of various somatosensory signals. Recently, the single...

A treasure reservoir of genetic resource of tea plant (Camellia sinensis) in Dayao Mountain

Components of 29 wild type tea single plants collected from Dayao Mountain, in Guangxi province, South China, were investigated. They included tea polyphenols, free amino acids, catechin, amino acid and alkaloid monomers etc. Genetic diversity and clustering analyses were conducted based on the main biochemical components. Meanwhile, genetic relationships among 6 wild type tea...

Semisolid slurry of 7A04 aluminum alloy prepared by electromagnetic stirring and Sc, Zr additions

Slurry preparation is one of the most critical steps for semisolid casting, and its primary goal is to prepare slurry with uniformly distributed fine globules. In this work, electromagnetic stirring (EMS) and the addition of Sc and Zr elements were used to prepare semisolid slurry of 7A04 aluminum alloy in a large diameter slurry maker. The effects of different treatments on the...

Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis

. Methodology: Liangyou Gu. Project administration: Yu Zhang. Resources: Xiangjun Lyu. Software: Luyao Chen. Supervision: Xu Zhang. 11 / 14 Validation: Xu Zhang. Visualization: Jianwen Chen. Writing

Baofukang suppository promotes the repair of vaginal epithelial cells in response to Candida albicans

Vulvovaginal candidiasis (VVC) is an opportunistic fungal infection predominantly caused by Candida albicans affecting a significant number of women of reproductive age. The Chinese medicine, the Baofukang suppository is widely used in the clinic for its antimicrobial activity and is therefore of great interest as a potential antifungal drug for the prevention of VVC. We...

Influence of tumor size on oncological outcomes of pathological T3aN0M0 renal cell carcinoma treated by radical nephrectomy

Objective To evaluate the prognostic significance of tumor size in pathological T3aN0M0 renal cell carcinoma (RCC) treated by radical nephrectomy. Materials and methods Patients who underwent radical nephrectomy for sporadic RCC with pathological T3aN0M0 RCC at our institution between January 2006 and June 2015 were identified. The entire cohort was divided into two groups...

Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle

The growth and maturity of cattle body size affect not only feed efficiency, but also productivity and longevity. Dissecting the genetic architecture of body size is critical for cattle breeding to improve both efficiency and productivity. The volume and weight of body size are indicated by several measurements. Among them, Heart Girth (HG) and Hip Height (HH) are the most...

A motion-classification strategy based on sEMG-EEG signal combination for upper-limb amputees

Background Most of the modern motorized prostheses are controlled with the surface electromyography (sEMG) recorded on the residual muscles of amputated limbs. However, the residual muscles are usually limited, especially after above-elbow amputations, which would not provide enough sEMG for the control of prostheses with multiple degrees of freedom. Signal fusion is a possible...

A new method for noninvasive venous blood oxygen detection

Background Blood oxygen saturation of vein (SvO2) is an important clinical parameter for patient monitoring. However, the existing clinical methods are invasive, expensive, which are also painful for patients. Methods Based on light-absorption, this study describes a new noninvasive SvO2 measurement method by using external stimulation signal to generate cyclical fluctuation...

The Extent of the Crack on Artificial Simulation Models with CBCT and Periapical Radiography

Background The aim of this study was to investigate the extent of the crack of a cracked tooth on an artificial simulation model with Periapical Radiography (PR) and cone beam computed tomography (CBCT) in vitro, providing the basis for early diagnosis and an appropriate treatment plan. Methods Forty-four teeth with different extents of artificial cracks, created by exposure to...

Pdcd2l Promotes Palmitate-Induced Pancreatic Beta-Cell Apoptosis as a FoxO1 Target Gene

Transcription factor FoxO1 is a key regulator of the insulin-signaling pathway, and is reported to play important roles in pancreatic β cell differentiation, proliferation, apoptosis and stress resistance. The multifunctional nature of FoxO1 is due to its regulation of various downstream targets. Previous studies in our lab identified potential FoxO1 target genes using the ChIP...