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9 papers found.
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Gα-cAMP/PKA pathway positively regulates pigmentation, chaetoglobosin A biosynthesis and sexual development in Chaetomium globosum

(#2015NT10), and an Open Fund of Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education (#201502). Author Contributions Conceptualization: Xudong Zhu. Data curation: Yang Hu ... , Xiaoran Hao. 15 / 18 Formal analysis: Yang Hu. Funding acquisition: Xiaoran Hao, Xudong Zhu. Investigation: Yang Hu, Longfei Chen, Oren Akhberdi, Xi Yu. Methodology: Yang Hu, Longfei Chen, Oren Akhberdi

Miltefosine Suppresses Hepatic Steatosis by Activating AMPK Signal Pathway

Background and Purpose It has been accepted that AMPK (Adenosine monophosphate–activated protein kinase) activation exhibits many beneficial effects on glucolipid metabolism. Lysophosphatidylcholine (LPC) is an important lysophospholipid which can improve blood glucose levels in diabetic mice and attenuate inflammation by activating AMPK signal pathway in macrophages. Synthetic...

Current aging research in China

, National Natural Science Foundation of China; PD, Parkinson's disease; SCNT, somatic cell nuclear transfer. COMPLIANCE WITH ETHICS GUIDELINES Ruijuan Sun, Heqi Cao, Xudong Zhu, Jun-Ping Liu, and Erdan Dong

Krüppel-like factor 12 is a novel negative regulator of forkhead box O1 expression: a potential role in impaired decidualization

Background Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. Krüppel-like factor 12 (KLF12) is a negative regulator of endometrial decidualization in vitro. We investigated whether KLF12 was associated with impaired decidualization under conditions of repeated implantation failure (RIF). Methods Uterine tissues were collected from a...

Identification and Functional Demonstration of miRNAs in the Fungus Cryptococcus neoformans

microRNAs (miRNAs), endogenous posttranscriptional repressors by base-pairing of their cognate mRNAs in plants and animals, have mostly been thought lost in the kingdom of fungi. Here, we report the identification of miRNAs from the fungus Cryptococcus neoformans. With bioinformatics and Northern blotting approaches, we found that these miRNAs and their hairpin precursors were...

A PKS gene, pks-1, is involved in chaetoglobosin biosynthesis, pigmentation and sporulation in Chaetomium globosum

Chaetomium globosum is one of the most common fungi in nature. It is best known for producing chaetoglobosins; however, the molecular basis of chaetoglobosin biosynthesis is poorly understood in this fungus. In this study, we utilized RNA interference (RNAi) to characterize a polyketide synthase gene, pks-1, in C. globosum that is involved in the production of chaetoglobosin A...

Deletion of Class A Scavenger Receptor Deteriorates Obesity-Induced Insulin Resistance in Adipose Tissue

Resistance in Adipose Tissue 0 Xudong Zhu , Guijuan Zong, Liu Zhu, Yuchen Jiang, Ke Ma, Hanwen Zhang, Yan Zhang, Hui Bai, Qing Yang, Jingjing Ben, Xiaoyu Li, Yong Xu, Qi Chen - Chronic low-grade

Interaction of influenza virus NS1 protein with growth arrest-specific protein 8

NS1 protein is the only non-structural protein encoded by the influenza A virus, and it contributes significantly to disease pathogenesis by modulating many virus and host cell processes. A two-hybrid screen for proteins that interact with NS1 from influenza A yielded growth arrest-specific protein 8. Gas8 associated with NS1 in vitro and in vivo. Deletion analysis revealed that...

Conserved and specific functions of mammalian ssu72

We describe the cloning and characterization of a human homolog of the yeast transcription/RNA-processing factor Ssu72, following a yeast two-hybrid screen for pRb-binding factors in the prostate gland. Interaction between hSsu72 and pRb was observed in transfected mammalian cells and involved multiple domains in pRb; however, so far, mutual effects of these two factors could not...