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11 papers found.
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HbA1c is Positively Associated with Serum Carcinoembryonic Antigen (CEA) in Patients with Diabetes: A Cross-Sectional Study

manuscript; Hongtao Wang collected data, Xueli Zhang and Xuemei Yu participated in the design of this study and edited the manuscript. Disclosures. Jun Lu, Hongtao Wang, Xueli Zhang, and Xuemei Yu have

Genetic dissection of main and epistatic effects of QTL based on augmented triple test cross design

. Formal analysis: Xueli Zhang, Congwei Sun, Xiong Yuan. Investigation: Xueli Zhang, Congwei Sun, Zheng Zhang, Zhijun Dai, Yuan Chen, Xiong Yuan. Methodology: Congwei Sun, Zheng Zhang, Zhijun Dai, Yuan ... Chen, Zheming Yuan, Wenbang Tang, Lanzhi Li, Zhongli Hu. Writing ± original draft: Xueli Zhang, Lanzhi Li. Writing ± review & editing: Xueli Zhang, Congwei Sun. 23 / 25 24 / 25 1. Shull GH . The

Systematic engineering of pentose phosphate pathway improves Escherichia coli succinate production

Background Succinate biosynthesis of Escherichia coli is reducing equivalent-dependent and the EMP pathway serves as the primary reducing equivalent source under anaerobic condition. Compared with EMP, pentose phosphate pathway (PPP) is reducing equivalent-conserving but suffers from low efficacy. In this study, the ribosome binding site library and modified multivariate modular...

Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli

Background Plasmid expression is a popular method in studies of MVA pathway for isoprenoid production in Escherichia coli. However, heterologous gene expression with plasmid is often not stable and might burden growth of host cells, decreases cell mass and product yield. In this study, MVA pathway was divided into three modules, and two heterologous modules were integrated into...

Development of a modularized two-step (M2S) chromosome integration technique for integration of multiple transcription units in Saccharomyces cerevisiae

Background Saccharomyces cerevisiae has already been used for heterologous production of fuel chemicals and valuable natural products. The establishment of complicated heterologous biosynthetic pathways in S. cerevisiae became the research focus of Synthetic Biology and Metabolic Engineering. Thus, simple and efficient genomic integration techniques of large number of...

A novel point mutation in RpoB improves osmotolerance and succinic acid production in Escherichia coli

Background Escherichia coli suffer from osmotic stress during succinic acid (SA) production, which reduces the performance of this microbial factory. Results Here, we report that a point mutation leading to a single amino acid change (D654Y) within the β-subunit of DNA-dependent RNA polymerase (RpoB) significantly improved the osmotolerance of E. coli. Importation of the D654Y...

Development of a fast and easy method for Escherichia coli genome editing with CRISPR/Cas9

Background Microbial genome editing is a powerful tool to modify chromosome in way of deletion, insertion or replacement, which is one of the most important techniques in metabolic engineering research. The emergence of CRISPR/Cas9 technique inspires various genomic editing methods. Results In this research, the goal of development of a fast and easy method for Escherichia coli...

In Vivo Optical Imaging of Interscapular Brown Adipose Tissue with 18F-FDG via Cerenkov Luminescence Imaging

Imaging of Interscapular Brown Adipose 18 Tissue with F-FDG via Cerenkov Luminescence Imaging Xueli Zhang 0 Chaincy Kuo 0 Anna Moore 0 Chongzhao Ran 0 Juri G. Gelovani, Wayne State University, United

GLP-1R–Targeting Magnetic Nanoparticles for Pancreatic Islet Imaging

Noninvasive assessment of pancreatic β-cell mass would tremendously aid in managing type 1 diabetes (T1D). Toward this goal, we synthesized an exendin-4 conjugated magnetic iron oxide–based nanoparticle probe targeting glucagon-like peptide 1 receptor (GLP-1R), which is highly expressed on the surface of pancreatic β-cells. In vitro studies in βTC-6, the β-cell line, showed...

Genomic Change, Retrotransposon Mobilization and Extensive Cytosine Methylation Alteration in Brassica napus Introgressions from Two Intertribal Hybridizations

Hybridization and introgression represent important means for the transfer and/or de novo origination of traits and play an important role in facilitating speciation and plant breeding. Two sets of introgression lines in Brassica napus L. were previously established by its intertribal hybridizations with two wild species and long-term selection. In this study, the methods of...

Assessment of dietary intake among pregnant women in a rural area of western China

Background Adequate maternal nutrient intake during pregnancy is important to ensure satisfactory birth outcomes. There are no data available on the usual dietary intake among pregnant women in rural China. The present study describes and evaluates the dietary intake in a cohort of pregnant women living in two counties of rural Shaanxi, western China. Methods 1420 pregnant women...