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ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database

Current pharmaceutical research and development (R&D) is a high-risk investment which is usually faced with some unexpected even disastrous failures in different stages of drug discovery. One main reason for R&D failures is the efficacy and safety deficiencies which are related largely to absorption, distribution, metabolism and excretion (ADME) properties and various toxicities...

Comparative analysis of human sperm glycocalyx from different freezability ejaculates by lectin microarray and identification of ABA as sperm freezability biomarker

BackgroundSemen cryopreservation has been widely applied in assisted reproductive technologies and sperm bank, but it causes considerable impairments on sperm quality. It is necessary to find an evaluation indicator for determining the sperm-freezing tolerance.MethodsThe glycocalyx of good freezability ejaculates was compared with poor freezability ejaculates by lectin microarray...

Study on the interaction of paeoniflorin with human serum albumin (HSA) by spectroscopic and molecular docking techniques

The interaction of paeoniflorin with human serum albumin (HSA) was investigated using fluorescence, UV–vis absorption, circular dichroism (CD) spectra and molecular docking techniques under simulative physiological conditions. The results clarified that the fluorescence quenching of HSA by paeoniflorin was a static quenching process and energy transfer as a result of a newly...

Polydopamine-assisted functionalization of heparin and vancomycin onto microarc-oxidized 3D printed porous Ti6Al4V for improved hemocompatibility, osteogenic and anti-infection potencies

Enhanced antiinfection activities, improved hemocompatibility and osteo-compatibility, and reinforced osseointegration are among the most important considerations in designing multifunctional orthopedic biomaterials. Hereby, anti-infective and osteogenic multifunctional 3D printed porous Ti6Al4V implant with excellent hemocompatibility was successfully designed and fabricated. In...

Sertoli Cell Wt1 Regulates Peritubular Myoid Cell and Fetal Leydig Cell Differentiation during Fetal Testis Development

Sertoli cells play a significant role in regulating fetal testis compartmentalization to generate testis cords and interstitium during development. The Sertoli cell Wilms’ tumor 1 (Wt1) gene, which encodes ~24 zinc finger-containing transcription factors, is known to play a crucial role in fetal testis cord assembly and maintenance. However, whether Wt1 regulates fetal testis...

Information Mismatch: Cancer Risk Counseling with Diverse Underserved Patients

Janice Ka Yan Cheng declare that they have no conflict of interest. Human Studies and Informed Consent No human studies were carried out by the authors for this article. Open Access This article is

Male germ cells support long-term propagation of Zika virus

Research journals • PubMed • Google Scholar Search for C. Yan Cheng in:Nature Research journals • PubMed • Google Scholar Search for Marco Seandel in:Nature Research journals • PubMed • Google Scholar ... ., M.S., C.M.R., C.Y.C., M.S., and S.C. analyzed results and wrote the manuscript. Competing interests The authors declare no competing interests. Corresponding authors Correspondence to C. Yan Cheng or

Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis

Objective Overexpression of survivin has been reported in many human tumors. However, the clinicopathological features associated with survivin overexpression in cervical carcinoma remain controversial. Thus, the current meta-analysis was performed to assess the clinicopathological significance of survivin in cervical carcinoma. Methods PubMed, EMBASE, and Web of Science...

The critical roles of mitophagy in cerebral ischemia

Hong Kong Baptist University (FRG2/15-16/022) and the Guandong Natural Science Foundation (2014A030313766 and 2016A030313008) . COMPLIANCE WITH ETHICS GUIDELINES Yan-Cheng Tang, Hong-Xia Tian, Tao Yi

Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells

Wing-yee Lui in:Nature Research journals • PubMed • Google ScholarSearch for Will M. Lee in:Nature Research journals • PubMed • Google ScholarSearch for C. Yan Cheng in:Nature Research journals • PubMed ... no competing financial interests. Corresponding author Correspondence to C. Yan Cheng. Supplementary information PDF files1.Supplementary Information Rights and permissions This work is

Efficacy and safety of olanzapine for treatment of patients with bipolar depression: Chinese subpopulation analysis of a double-blind, randomized, placebo-controlled study

Efficacy and safety of olanzapine for treatment of patients with bipolar depression: Chinese subpopulation analysis of a double-blind, randomized, placebo-controlled study Gang Wang,1–3 Yan Cheng,4 ... -controlled study gang Wang 2 Yan cheng 4 Jia Ning Wang 4 sheng hu 0 c enter of Depression, Beijing institute for Brain Disorders , Beijing, People's r epublic of china 1 c hina c linical r esearch center for

Isolated right ventricular hypoplasia caused by giant aneurysm of right coronary artery to left ventricle fistula in an adult: a case report

Background Right ventricular hypoplasia (RVH) is often caused by tricuspid valve atresia and pulmonary valve atresia. this condition leads to low right ventricular blood volume and right ventricular maldevelopment. But, in adults, the main cause of RVH may also be associated with alloplasia of the right coronary artery, which results in an insufficient blood supply to the right...

Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect

National Basic Research Program of China (973 Program, 2015CB910700) (Yan CHENG) and the National Natural Science Foundation of China (81422051, 81472593, and 31401208) (Yan CHENG). Author information ... ScholarSearch for Yi-di Guan in:Nature Research journals • PubMed • Google ScholarSearch for Jin-ming Yang in:Nature Research journals • PubMed • Google ScholarSearch for Yan Cheng in:Nature Research journals

Activation of proHGF by St14 induces mouse embryonic stem cell differentiation

), Shu Guang Project of Shanghai Education Commission (No. 10GG10). Xiaoshuang Yan, Yan Xue, Yiye Zhou, Yan Cheng, Shang Yin, Qingwen Ma, and Fanyi Zeng declare that they have no conflict of interest. All

Chemotherapy versus radiotherapy for FIGO stages IB1 and IIA1 cervical carcinoma patients with postoperative isolated deep stromal invasion: a retrospective study

Background The adjuvant treatment for patients with isolated stromal invasion after radical hysterectomy and pelvic lymph node dissection (PLND) in FIGO stage IB1 and IIA1 cervical carcinoma has not been established. This study assessed the survival outcomes and recurrent patterns in this particular group of patients treated with chemotherapy or radiation-based adjuvant therapy...

Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43

Cheng OPEN Perfluorooctanesulfonate (PFOS) is an environmental toxicant used in developing countries, including China, as a stain repellent for clothing, carpets and draperies, but it has been banned in

Celiac Disease Autoimmunity in Patients with Autoimmune Diabetes and Thyroid Disease among Chinese Population

The prevalence of celiac disease autoimmunity or tissue transglutaminase autoantibodies (TGA) amongst patients with type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) in the Chinese population remains unknown. This study examined the rate of celiac disease autoimmunity amongst patients with T1D and AITD in the Chinese population. The study included 178 patients with type...

Alteration of Blood Flow in a Venular Network by Infusion of Dextran 500: Evaluation with a Laser Speckle Contrast Imaging System

This study examined the effect of dextran-induced RBC aggregation on the venular flow in microvasculature. We utilized the laser speckle contrast imaging (LSCI) as a wide-field imaging technique to visualize the flow distribution in venules influenced by abnormally elevated levels of RBC aggregation at a network-scale level, which was unprecedented in previous studies. RBC...