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Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis

Crohn’s disease (CD) is a chronic inflammatory bowel disease that is difficult to treat. However, previous preclinical and clinical studies have shown that mesenchymal stromal cells (MSCs) are a promising therapeutic approach, whereas the exact underlying molecular mechanisms of MSCs in treating CD remain unclear. Furthermore, the heterogeneity of MSCs, as well as the in vivo...

Screening novel stress granule regulators from a natural compound library

.-J. Chen was supported by the Excellent Postdoctoral fellowship from the Tsinghua-Peking Joint Center for Life Sciences. Li-Dan Hu, Xiang-Jun Chen, Xiao-Yan Liao and Yong-Bin Yan declare no conflict ... experiments. LDH, XJC, and YBY analyzed the data. LDH and YBY wrote the paper. Li-Dan Hu, Xiang-Jun Chen, Xiao-Yan Liao, Yong-Bin Yan& OPEN ACCESS This article is distributed under the terms of the Creative

Up-regulation of BRCA1-associated RING Domain 1 Promotes Hepatocellular Carcinoma Progression by Targeting Akt Signaling

of Guangxi (No. 2015GXNSFAA139111), and the Science and Technology Planning Project of Guilin (No. 20150206-1-10). Author information Author notes Yan Liao, Shengguang Yuan and Xinhuang Chen ... Medical University, Guilin, Guangxi, P.R. ChinaShengguang Yuan AuthorsSearch for Yan Liao in:Nature Research journals • PubMed • Google Scholar Search for Shengguang Yuan in:Nature Research journals

High-performance wireless powering for peripheral nerve neuromodulation systems

S. Y. Poon. Resources: Song-Yan Liao, Zhe Zhen, Zi-Yi Zhu. Supervision: John S. Ho, Hung Fat Tse, Ada S. Y. Poon. 10 / 13 Validation: Yuji Tanabe. Writing ± original draft: Yuji Tanabe, John S. Ho

Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling

Intrahepatic cholangiocarcinoma (ICC) is an aggressive tumor with a high fatality rate. It was recently found that parathyroid hormone-like hormone (PTHLH) was frequently overexpressed in ICC compared with non-tumor tissue. This study aimed to elucidate the underlying mechanisms of PTHLH in ICC development. The CCK-8 assay, colony formation assays, flow cytometry and a xenograft...

Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?

Heart failure after myocardial infarction is the leading cause of mortality and morbidity worldwide. Existing medical and interventional therapies can only reduce the loss of cardiomyocytes during myocardial infarction but are unable to replenish the permanent loss of cardiomyocytes after the insult, which contributes to progressive pathological left ventricular remodeling and...

How do amino acid substitutions affect the amyloidogenic properties and seeding efficiency of prion peptides

The amino acid sequences in the amyloidogenic region (amino acids 108–144) of several mammalian prion proteins were compared and variations were found to occur at residues 109 (M or L), 112 (M or V), 129 (M, V, or L), 135 (N or S), 138 (M, L, or I), 139 (M or I), and 143 (N or S). Using the bovine PrP peptide (residues 108–144 based on the numbering of the human prion protein...

Lack of Cardiac Nerve Sprouting after Intramyocardial Transplantation of Bone Marrow-Derived Stem Cells in a Swine Model of Chronic Ischemic Myocardium

Previous experimental studies suggested that mesenchymal stem cell transplantation causes cardiac nerve sprouting; however, whether bone marrow (BM)-derived mononuclear cells (MNC) and endothelial progenitor cells (EPC) can also lead to cardiac nerve sprouting and alter gap junction expression remains unclear. We investigated the effect of electroanatomical mapping-guided direct...

Information-Seeking Behavior of International Graduate Students vs. American Graduate Students: A User Study at Virginia Tech 2005

Yan Liao 0 Mary Finn 0 Jun L 0 0 Yan Liao served as Cataloging Librarian at Virginia Polytechnic Institute and State University Library and currently works at Georgetown University Law Library as

The biological effect of 125I seed continuous low dose rate irradiation in CL187 cells

Background To investigate the effectiveness and mechanism of 125I seed continuous low-dose-rate irradiation on colonic cell line CL187 in vitro. Methods The CL187 cell line was exposed to radiation of 60Coγ ray at high dose rate of 2 Gy/min and 125I seed at low dose rate of 2.77 cGy/h. Radiation responses to different doses and dose rates were evaluated by colony-forming assay...