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604 papers found.
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Osthole inhibits gastric cancer cell proliferation through regulation of PI3K/AKT

project of Jiangsu province under Grant QNRC2016166 and Doctor Fund of Wuxi Health Bureau under Grant 2014BS01. Author Contributions Conceptualization: Yan Zhang. Data curation: Xiaojun Xu, Yan Zhang ... . Formal analysis: Xiaoyuan Liu, Yan Zhang. Funding acquisition: Yan Zhang. Methodology: Xiaojun Xu, Yan Zhang. Project administration: Yan Zhang. Resources: Yan Zhang. 8 / 10 Software: Xiaoyuan Liu, Yan

Robust solutions to box-constrained stochastic linear variational inequality problem

We present a new method for solving the box-constrained stochastic linear variational inequality problem with three special types of uncertainty sets. Most previous methods, such as the expected value and expected residual minimization, need the probability distribution information of the stochastic variables. In contrast, we give the robust reformulation and reformulate the ...

Prediction of loss to follow-up in long-term supportive periodontal therapy in patients with chronic periodontitis

, Yan Zhang, Xiu E. Li, Chun Mei Wang. Resources: Chun Mei Wang. Software: Yan Zhang. Supervision: Yan Zhang, Xiu E. Li, Chun Mei Wang. 10 / 12 Validation: Hai Jing Yang, Chun Mei Wang. Visualization

Economic Dispatch Model Based on Time-of-Use Electricity Price for Photovoltaic Systems

Due to the energy storage limitations of photovoltaic systems and the uneven time-of-use of electricity by users and the policies of different time-of-use electricity price, scheduling and dispatching of photovoltaic systems incurs irregular trend of electricity consumption and associated price hikes which influences by supply and demand. To this end, this paper proposes a novel ...

Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer’s disease by regulating cilia function

Background Serotonin receptor 5-HT6 is involved in cognition and Alzheimer’s disease (AD) development. However, the mechanism of 5-HT6 in AD pathology is not clear. Methods Since 5-HT6 is almost exclusively expressed in the primary cilia, using immunostaining we examined the number of cilia in the hippocampus of AD animal model APP/PS1 mice. By overexpressing and knocking down ...

Simultaneous determination of brazilin and protosappanin B in Caesalpinia sappan by ionic-liquid dispersive liquid-phase microextraction method combined with HPLC

The conditions of heating, ionic liquid-based ultrasonic-assisted extraction combined with reverse-phase high performance liquid chromatography were optimized to simultaneously isolate and determinate brazilin and protosappanin B in Caesalpinia sappan. Ionic liquids, including [BMIM]Br, [BMIM]BF4, [BMIM]PF6 and [HMIM]PF6, were selected as extraction solvents while methanol, ...

Social exclusion leads to attentional bias to emotional social information: Evidence from eye movement

: Zhuohao Chen, Shuyue Zhang. Data curation: Zhuohao Chen, Jinchen Du. Formal analysis: Zhuohao Chen, Yan Zhang. Funding acquisition: Shuyue Zhang. Investigation: Zhuohao Chen. Methodology: Jinchen Du ... , Yan Zhang. 16 / 19 Project administration: Yan Zhang, Shuyue Zhang. Resources: Shuyue Zhang. Software: Zhuohao Chen, Jinchen Du. Supervision: Yan Zhang, Shuyue Zhang. Writing ± original draft

Wide-viewing integral imaging system using polarizers and light barriers array

Zhang 0 0 School of Physics Optoelectronic Engineering, Xidian University , Xi'an 710071 , China Background: Integral imaging is considered one of the most promising three-dimensional display

Gene activation in human cells using CRISPR/Cpf1-p300 and CRISPR/Cpf1-SunTag systems

, Lin Shan, Le Han, Shufeng Ma, Yan Zhang, Bingtao Hao, Ying Lin and Zhili Rong declare that they have no conflict of interest. Xin Zhang, Wei Wang, Lin Shan, Le Han, Shufeng Ma, Yan Zhang, Bingtao Hao

Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

Long-term use of morphine induces analgesic tolerance, which limits its clinical efficacy. Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor protein 3 (NLRP3) inflammasome was important for morphine tolerance. In our study, we investigated whether other existing alternative pathways caused morphine-induced activation of ...

The impact of methylation quantitative trait loci (mQTLs) on active smoking-related DNA methylation changes

Background Methylation quantitative trait loci (mQTLs) are the genetic variants that may affect the DNA methylation patterns of CpG sites. However, their roles in influencing the disturbances of smoking-related epigenetic changes have not been well established. This study was conducted to address whether mQTLs exist in the vicinity of smoking-related CpG sites (± 50 kb) and to ...

Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord

University, Department of Pharmacology, Nanjing Medical University , Nanjing, Jiangsu 211166 , China 2 Yan Zhang and Gao-Jian Tao are first authors 3 Department of Pain, Affiliated Drum Tower Hospital, Medical

Pediatric Dosing of Intravenous Sotalol Based on Body Surface Area in Patients with Arrhythmia

In a recently published study, we evaluated the efficacy and safety of intravenous sotalol in pediatric patients with incessant tachyarrhythmias and we have found that intravenous sotalol is effective and safe. Our dosing regimen was based on the body weight of the patients. In the US, the recommendation for intravenous sotalol dosing in pediatric patients is based on body surface ...

Performance of back-illuminated \(\hbox {In}_{0.09}\hbox {Ga}_{0.91}\hbox {N}\) -based p–i–n photodetector

In this paper, the back-illuminated \(\hbox {In}_{0.09}\hbox {Ga}_{0.91}\hbox {N}\) p–i–n ultraviolet photodetectors have been fabricated and simulated. The responsivity characteristic was shown experimentally and theoretically. The peak responsivity of photodetector was improved from 0.06 A/W at 394 nm to 0.19 A/W at 402 nm since the growth of a 30 nm i-GaN layer between i-InGaN ...

NiCo2S4@NiMoO4 Core-Shell Heterostructure Nanotube Arrays Grown on Ni Foam as a Binder-Free Electrode Displayed High Electrochemical Performance with High Capacity

Core-shell-structured system has been proved as one of the best architecture for clean energy products owing to its inherited superiorities from both the core and the shell part, which can provide better conductivity and high surface area. Herein, a hierarchical core-shell NiCo2S4@NiMoO4 heterostructure nanotube array on Ni foam (NF) (NiCo2S4@NiMoO4/NF) has been successfully ...

Analysis of a nonautonomous stochastic predator-prey model with Crowley-Martin functional response

The objective of this paper is to study some qualitative dynamic properties of a nonautonomous predator-prey model with stochastic perturbation and Crowley-Martin functional response. The existence of a global positive solution and stochastically ultimate boundedness are obtained. Sufficient conditions for extinction, persistence in the mean, and stochastic permanence of the system ...

Individual CpG sites that are associated with age and life expectancy become hypomethylated upon aging

Background There is a growing interest in simple molecular biomarkers for biological aging. Age-associated DNA methylation (DNAm) changes at specific CG dinucleotides can be combined into epigenetic age predictors to estimate chronological age—and the deviation of chronological and predicted age (∆age) seems to be associated with all-cause mortality. In this study, we have further ...