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171 papers found.
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Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials

. 31671418 and no. 31471361) and Fundamental Research Funds for the Central Universities (2042017kf0205 and 2042017kf0242) to Yan Zhou. References R. Stupp, W. P. Mason, M. J. van den Bent et al

Methylation-level inferences and detection of differential methylation with MeDIP-seq data

Conceptualization: Jiadi Zhu, Mingtao Zhao. Methodology: Yan Zhou, Baoxue Zhang, Chunfu Jiang. 12 / 13 Software: Xiyan Yang. Supervision: Yan Zhou. Writing ± original draft: Yan Zhou. 1. Irizarry RA , Acosta CL

Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial

BackgroundIntrauterine adhesions (IUA) are the most common cause of uterine infertility and are caused by endometrium fibrotic regeneration following severe damage to the endometrium. Although current stem cell treatment options using different types of autologous stem cells have exhibited some beneficial outcomes in IUA patients, the reported drawbacks include variable...

Circulating microRNAs from the miR-106a–363 cluster on chromosome X as novel diagnostic biomarkers for breast cancer

-363 cluster as promising novel biomarkers for the diagnosis of BC. Circulating microRNA; Breast cancer; Diagnosis; Exosomes; qRT-PCR - Minghui Li, Yan Zhou and Tiansong Xia have contributed equally

Isolation, identification, and characterization of an Aspergillus niger bioflocculant-producing strain using potato starch wastewater as nutrilite and its application

) and the Project Funded by China Postdoctoral Science Foundation (2015T80966). Author Contributions Conceptualization: Shengyan Pu, Yan Zhou. Data curation: Shengyan Pu, Hui Ma, Xingying Xiong ... : Shengyan Pu, Hui Ma, Daili Deng, Shengyang Xue. Writing ± review & editing: Shengyan Pu, Rongxin Zhu, Yan Zhou. 15 / 17 10. Wang RM, Wang Y, He YF, Li FY, Zhou Y, He NP. Preparation of solid composite

Increased expression of Th17 cytokines and interleukin-22 correlates with disease activity in pristane-induced arthritis in rats

experiments. Author Contributions Conceptualization: Bo Wang, Shemin Lu, Weikun Hou. Formal analysis: Bo Wang, Panpan Zhao, Liesu Meng. Funding acquisition: Bo Wang, Yan Zhou, Weikun Hou. Investigation: Bo ... . Validation: Bo Wang, Panpan Zhao, Linyu Wang, Yongsong Cai. Visualization: Bo Wang, Panpan Zhao, Yan Zhou, Linyu Wang, Yongsong Cai. Writing ± original draft: Bo Wang, Panpan Zhao, Linyu Wang, Yongsong Cai

Developing a novel dual PI3K–mTOR inhibitor from the prodrug of a metabolite

Developing a novel dual PI3K-mTOR inhibitor from the prodrug of a metabolite Yan Zhou,1,2 Genyan Zhang,2 Feng Wang,2 Jin Wang,2 Yanwei Ding,2 Xinyu Li,2 Chongtie Shi,2 Jiakui Li,2 Chengkon Shih,2 ... Shu, and Dr Frank Wu. Disclosure Yan Zhou, Genyan Zhang, Feng Wang, Jin Wang, Yanwei Ding, Xinyu Li, Chongtie Shi, Jiakui Li and Chengkon Shih all work for Xuanzhu Pharma, Jinan, China. The authors

Burial depth interval of the shale brittle–ductile transition zone and its implications in shale gas exploration and production

Brittleness and ductility of shale are closely related to shale gas exploration and production. How to predict brittleness and ductility of shale is one of the key issues in the study of shale gas preservation and hydraulic fracturing treatments. The magnitude of shale brittleness was often determined by brittle mineral content (for example, quartz and feldspars) in shale gas...

Anaplastic lymphoma kinase-positive large B-cell lymphoma: Clinico-pathological study of 17 cases with review of literature

We retrospectively analysed 17 cases of anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+, LBCL) according to the morphological, immunohistochemical, molecular and clinical features, using which we intend to elucidate the clinicopathological characteristics of this rare entity. In this study, all cases de facto share common features that defined them as a single...

A Hypothesis Testing Based Method for Normalization and Differential Expression Analysis of RNA-Seq Data

Next-generation sequencing technologies have made RNA sequencing (RNA-seq) a popular choice for measuring gene expression level. To reduce the noise of gene expression measures and compare them between several conditions or samples, normalization is an essential step to adjust for varying sample sequencing depths and other unwanted technical effects. In this paper, we develop a...

A review on approaches to solving Poisson’s equation in projection-based meshless methods for modelling strongly nonlinear water waves

Three meshless methods, including incompressible smooth particle hydrodynamic (ISPH), moving particle semi-implicit (MPS) and meshless local Petrov–Galerkin method based on Rankine source solution (MLPG_R) methods, are often employed to model nonlinear or violent water waves and their interaction with marine structures. They are all based on the projection procedure, in which...

Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens

, Neil Beeharry, Shao-shan Carol Huang, Yan Zhou. Supervision: Sara J. C. Gosline, Shao-shan Carol Huang, Tim Yen, Ernest Fraenkel. Validation: Oana Ursu, Sara J. C. Gosline, Neil Beeharry, Lauren Fink ... , Vikram Bhattacharjee, Shao-shan Carol Huang, Yan Zhou. Visualization: Oana Ursu, Sara J. C. Gosline, Neil Beeharry, Tim Yen. Writing ± original draft: Oana Ursu, Sara J. C. Gosline, Neil Beeharry, Tim

Circulating long non-coding RNAs in cancer: current status and future perspectives

Long non-coding RNAs (lncRNAs) comprise a diverse class of RNA transcripts >200 nucleotides in length with limited protein-coding potential. In addition to their possible role in cancer biology, circulating lncRNAs have emerged as a new class of promising cancer biomarkers, with independent studies demonstrating the feasibility of their use as tools in the diagnosis and prognosis...

A Reliability Test of a Complex System Based on Empirical Likelihood

To analyze the reliability of a complex system described by minimal paths, an empirical likelihood method is proposed to solve the reliability test problem when the subsystem distributions are unknown. Furthermore, we provide a reliability test statistic of the complex system and extract the limit distribution of the test statistic. Therefore, we can obtain the confidence...

The relationship between children’s oral health-related behaviors and their caregiver’s social support

Background Social support might play a role in helping people adopt healthy behaviors and improve their health. Stronger social support from mothers has been found to be positively related to higher tooth brushing frequency in 1- to 3-year-old children. However, little is known regarding the relationship between the caregiver’s social support and the oral health-related behaviors...

Analysis of the duodenal microbiotas of weaned piglet fed with epidermal growth factor-expressed Saccharomyces cerevisiae

Background The bacterial community of the small intestine is a key factor that has strong influence on the health of gastrointestinal tract (GIT) in mammals during and shortly after weaning. The aim of this study was to analyze the effects of the diets of supplemented with epidermal growth factor (EGF)-expressed Saccharomyces cerevisiae (S. cerevisiae) on the duodenal microbiotas...

Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance

 Santos Copyright © 2016 Yan Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any ... patients with MS. Competing Interests The authors declare that there are no competing interests regarding the publication of this paper. Authors’ Contributions Yan Zhou and Xiao Leng contributed equally to

Genome reduction of Borrelia burgdorferi: two TCS signaling pathways for two distinct host habitats

Yongliang Lou) and (81501772 to MeipingYe), Zhejiang Science Foundation (Y15H190025 to Yan Zhou). Caimano , M.J. , Dunham-Ems , S. , Allard , A.M. , Cassera , M.B. , Kenedy , M. , and Radolf , J.D. ( 2015

Characterization of human enterovirus71 virus-like particles used for vaccine antigens

Human enterovirus 71 (EV71) is a major causative pathogen of hand, foot and mouth disease (HFMD) and has caused outbreaks with significant mortality among young children in the Asia-Pacific region in recent years. Towards developing a vaccine for this disease, we have expressed and purified EV71 virus-like particles (VLPs), which resemble the authentic virus in appearance, capsid...