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Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention and treatment of AD. We performed in vivo two-photon calcium imaging to examine the activities of...

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention and treatment of AD. We performed in vivo two-photon calcium imaging to examine the activities of...

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention and treatment of AD. We performed in vivo two-photon calcium imaging to examine the activities of...

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention and treatment of AD. We performed in vivo two-photon calcium imaging to examine the activities of...

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention and treatment of AD. We performed in vivo two-photon calcium imaging to examine the activities of...

How Does the Concentration of Determinants Affect Industrial Innovation Performance? – An Empirical Analysis of 23 Chinese Industrial Sectors

The agglomeration of innovation determinants has a significant influence on the innovation performance of industries and enterprises. Such an effect has received less attention in empirical research studies. This study involves a survey of the agglomeration effect of two important innovation determinants, R&D investment and R&D personnel, and its influence on innovation...

Superbumps

For a wide range of supersymmetric models, there is a chiral superfield whose scalar and pseudo-scalar have approximately degenerate masses and couplings to Standard Model particles. At colliders, they may show up as “superbumps”: a pair of resonances with similar masses and production cross-sections. Observing the superbumps may provide evidence of supersymmetry even without...

Hydrogen axion star: metallic hydrogen bound to a QCD axion BEC

As a cold dark matter candidate, the QCD axion may form Bose-Einstein condensates, called axion stars, with masses around 10−11 M ⊙. In this paper, we point out that a brand new astrophysical object, a Hydrogen Axion Star (HAS), may well be formed by ordinary baryonic matter becoming gravitationally bound to an axion star. We study the properties of the HAS and find that the...

Experimental and visual research on the microbial induced carbonate precipitation by Pseudomonas aeruginosa

Microbial induced carbonate precipitation (MICP) is a common occurrence of geochemistry influences in many fields, such as biological, geographical, and engineering systems. However, the processes that control interactions between carbonate biomineralization and biofilm properties are poorly understood. We develop a method for real time, in situ and nondestructive imaging with...

Chromo-Rayleigh interactions of dark matter

For a wide range of models, dark matter can interact with QCD gluons via chromo-Rayleigh interactions. We point out that the Large Hadron Collider (LHC), as a gluon machine, provides a superb probe of such interactions. In this paper, we introduce simplified models to UV-complete two effective dark matter chromo-Rayleigh interactions and identify the corresponding collider...

Phenomenology of strongly coupled chiral gauge theories

A sector with QCD-like strong dynamics is common in models of non-standard physics. Such a model could be accessible in LHC searches if both confinement and big-quarks charged under the confining group are at the TeV scale. Big-quark masses at this scale can be explained if the new fermions are chiral under a new U(1)′ gauge symmetry such that their bare masses are related to the...

Geometric compatibility of IceCube TeV-PeV neutrino excess and its galactic dark matter origin

We perform a geometric analysis for the sky map of the IceCube TeV-PeV neutrino excess and test its compatibility with the sky map of decaying dark matter signals in our galaxy. We have found that a galactic decaying dark matter component in general improve the goodness of the fit of our model, although the pure isotropic hypothesis has a better fit than the pure dark matter one...

Targeting of topoisomerases for prognosis and drug resistance in ovarian cancer

Backgroud As magicians of the DNA world, topoisomerases resolve all of the topological problems in relation to DNA during a variety of genetic processes. While the prognostic value of topoisomerase isoenzymes in epithelial ovarian carcinoma (EOC) is still elusive. In current study, we investigated the prognostic value of topoisomerase isoenzymes in the EOC patients. Kaplan Meier...

Lepton Portal dark matter

Yang Bai 1 Joshua Berger 0 0 SLAC National Accelerator Laboratory , 2575 Sand Hill Road, Menlo Park, CA 94025, U.S.A 1 Department of Physics, University of Wisconsin , Madison, WI 53706, U.S.A We

A Triangle Mesh Standardization Method Based on Particle Swarm Optimization

To enhance the triangle quality of a reconstructed triangle mesh, a novel triangle mesh standardization method based on particle swarm optimization (PSO) is proposed. First, each vertex of the mesh and its first order vertices are fitted to a cubic curve surface by using least square method. Additionally, based on the condition that the local fitted surface is the searching...

Spectrum-doubled heavy vector bosons at the LHC

We study a simple effective field theory incorporating six heavy vector bosons together with the standard-model field content. The new particles preserve custodial symmetry as well as an approximate left-right parity symmetry. The enhanced symmetry of the model allows it to satisfy precision electroweak constraints and bounds from Higgs physics in a regime where all the couplings...

Dark matter searches with a mono-Z′ jet

We study collider signatures of a class of dark matter models with a GeV-scale dark Z ′. At hadron colliders, the production of dark matter particles naturally leads to associated production of the Z ′, which can appear as a narrow jet after it decays hadronically. Contrary to the usual mono-jet signal from initial state radiation, the final state radiation of dark matter can...

\( {J}_{E_T} \) : a global jet finding algorithm

We introduce a new jet-finding algorithm for a hadron collider based on maximizing a \( {J}_{E_T} \) function for all possible combinations of particles in an event. This function prefers a larger value of the jet transverse energy and a smaller value of the jet mass. The jet shape is proved to be a circular cone in Cartesian coordinates with the geometric center shifted from the...

Fermion portal dark matter

Yang Bai 1 Joshua Berger 0 0 SLAC National Accelerator Laboratory , 2575 Sand Hill Road, Menlo Park, CA 94025, U.S.A 1 Department of Physics, University of Wisconsin, 1150 University Avenue