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Evaluation of multicomponent recombinant vaccines against Actinobacillus pleuropneumoniae in mice

Background Porcine contagious pleuropneumonia (PCP) is a highly contagious disease that is caused by Actinobacillus pleuropneumoniae (APP) and characterized by severe fibrinous necrotizing hemorrhagic pleuropneumonia, which is a severe threat to the swine industry. In addition to APP RTX-toxins I (ApxI), APP RTX-toxin II (ApxII), APP RTX-toxin III (ApxIII) and Outer membrane...

Screening Level of PAHs in Sediment Core from Lake Hongfeng, Southwest China

Using data from a 25-year retrospective of polycyclic aromatic hydrocarbons (PAHs) in sediment core from Lake Hongfeng, Southwest China, their possible sources and potential toxicologic significance were investigated. The total PAH concentrations (16 priority PAHs as proposed by the United States Environmental Protection Agency) in sediments ranged from 2936.1 to 5282.3 ng/g and...

PD-L1-expressing neutrophils as a novel indicator to assess disease activity and severity of systemic lupus erythematosus

Background It is well-known that increased frequency of neutrophils was found in patients with systemic lupus erythematosus (SLE). However, the immunomodulatory roles and mechanisms of neutrophils in SLE are poorly understood. Methods Patients with SLE were recruited from the First Affiliated Hospital of Nanchang University. The medical history, clinical manifestations, physical...

Dexmedetomidine versus remifentanil for sedation during awake intubation using a Shikani optical stylet: a randomized, double-blinded, controlled trial

0 Cheng Ni 0 Xiang-yang Guo 0 0 Department of Anesthesiology, Peking University Third Hospital , Beijing 100191 , China Background: The purpose of this study was to compare the efficacy and safety of

Effects of two different anesthesia-analgesia methods on incidence of postoperative delirium in elderly patients undergoing major thoracic and abdominal surgery: study rationale and protocol for a multicenter randomized controlled trial

Background Delirium is a common complication in elderly patients after surgery and associated with increased morbidity and mortality. Studies suggest that deep anesthesia and intense pain are important precipitating factors of postoperative delirium. Neuraxial block is frequently used in combination with general anesthesia for patients undergoing major thoracic and abdominal...

Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels

Background The expression level of cyclin D1 plays a vital role in the control of proliferation. This protein is reported to be degraded following phosphorylation by glycogen synthase kinase 3 (GSK3) on Thr-286. We recently showed that phosphorylation of Thr-286 is responsible for a decline in cyclin D1 levels during S phase, an event required for efficient DNA synthesis. These...

Human rabies surveillance and control in China, 2005–2012

Background Rabies reemerged in China during the 1990s with a gradual increase in the number and geographical dispersion of cases. As a consequence, a national surveillance program was introduced in 2005 to investigate the outbreak in terms of vaccination coverage, PEP treatment, and geographical and social composition. Methods The surveillance program was coordinated at the...

Microarray analysis of MicroRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1)

Background With concerns about the disastrous health and economic consequences caused by the influenza pandemic, comprehensively understanding the global host response to influenza virus infection is urgent. The role of microRNA (miRNA) has recently been highlighted in pathogen-host interactions. However, the precise role of miRNAs in the pathogenesis of influenza virus infection...

High glucose induces apoptosis and suppresses proliferation of adult rat neural stem cells following in vitro ischemia

design, established the OGD model and drafted the manuscript. Yang Guo carried out western blot analysis, immunoassays, and statistical analysis. Wei Cheng participated in flow cytometry. Ruiqing Chen

EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-β1 and is a predictor of outcome in ovarian carcinoma patients

It was suggested that the enhancer of zeste homolog 2 (EZH2) gene is a putative candidate oncogene in several types of human cancer. The potential oncogenic role of EZH2 and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, EZH2 expression was examined by immunohistochemistry (IHC) in cohorts of normal and tumorous ovarian tissues...

VideoMap: An interactive and scalable visualization for exploring video content

VideoMap: An interactive exploring video content Cui-Xia Ma Yang Guo Hong-An Wang Large-scale dynamic relational data visualization has attracted considerable research attention recently. We ... , China, in 2003. She is now a professor with the Institute of Software, Chinese Academy of Sciences. Her research interests include human–computer interaction and multimedia computing. Yang Guo started

Comparative efficacy of glimepiride and metformin in monotherapy of type 2 diabetes mellitus: meta-analysis of randomized controlled trials

Background Metformin treatment has been the most recommended monotherapy of type 2 diabetes mellitus (T2DM) for decades but is challenged by new antidiabetic drugs. This study conducted a meta-analysis of randomized controlled trials (RCT) comparing the efficacy of metformin and glimepiride in monotherapy of T2DM. Methods A literature search for RCTs on glimepiride and metformin...

Photothermal ablation of pancreatic cancer cells with hybrid iron-oxide core gold-shell nanoparticles

Photothermal ablation of pancreatic cancer cells with hybrid iron-oxide core gold-shell nanoparticles Yang Guo,1 Zhuoli Zhang,1 Dong-Hyun Kim,1,5 Weiguo Li,1 Jodi Nicolai,1 Daniel Procissi,1 Yi Huan ... c h Yang guo 1 Weiguo li 1 Yi huan 2 guohong han 3 Purpose: Photothermal ablation is a minimally invasive approach, which typically involves delivery of photothermal sensitizers to targeted tissues

Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis

Hospital, School of Medicine, Zhejiang University , Hangzhou 310003 , China) 1 Project supported by the National High-Tech R & D Program (863) of China (No. 2015AA020306) ORCID: Yang GUO Liver fibrosis is ... . Compliance with ethics guidelines Yang GUO, Bo CHEN, Li-jun CHEN, Chun-feng ZHANG, and Charlie XIANG declare that they have no conflict of interest. This article does not contain any studies with human or

Ultrasound-guided RNA interference targeting HIF-1 alpha improves the effects of transarterial chemoembolization in rat liver tumors

Chen-Yang Guo,2 Wei Zhang,1 Zhi-Ping Yan,1 Rong Liu,1 Jian-Hua Wang1 1Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Department of ... scientific and medical research O r i g i n a l r e s e a r c h cheng-shi chen 1,2,* chen-Yang guo 2 *These authors contributed equally to this work Introduction Transarterial chemoembolization (TACE) and

Long noncoding RNA NEAT1 promotes nasopharyngeal carcinoma progression through regulation of miR-124/NF-κB pathway

OncoTargets and Therapy long noncoding rna nea T1 promotes nasopharyngeal carcinoma progression through regulation of mir-124/nF- κB pathway n an cheng 1 Yang guo 0 0 Department of Ophthalmology

Molecular Phylodynamic Analysis Indicates Lineage Displacement Occurred in Chinese Rabies Epidemics between 1949 to 2010

Rabies remains a serious problem in China with three epidemics since 1949 and the country in the midst of the third epidemic. Significantly, the control of each outbreak has been followed by a rapid reemergence of the disease. In 2005, the government implemented a rabies national surveillance program that included the collection and screening of almost 8,000 samples. In this work...

Concrete surface crack detection with the improved pre-extraction and the second percolation processing methods

. Software: Zhong Qu, Fang-Rong Ju, Yang Guo, Ling Bai, Kuo Chen. Visualization: Yang Guo, Ling Bai, Kuo Chen. Writing ± original draft: Zhong Qu, Fang-Rong Ju, Yang Guo, Ling Bai, Kuo Chen. Writing ± review