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Optimizing Non-Decomposable Evaluation Metrics for Neural Machine Translation

While optimizing model parameters with respect to evaluation metrics has recently proven to benefit end to-end neural machine translation (NMT), the evaluation metrics used in the training are restricted to be defined at the sentence level to facilitate online learning algorithms. This is undesirable because the final evaluation metrics used in the testing phase are usually ...

Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers

CART-HER2 cell infusion, and 2 cases of grade 1-2 HER2; CART; biliary tract cancers; pancreatic cancers; clinical trial - Kaichao Feng, Yang Liu and Yelei Guo contributed equally to this study ... ; TNF-alpha, tumor necrosis factor- alpha; Tregs, regulatory T cells; VEGF, vascular endothelial growth factor. COMPLIANCE WITH ETHICS GUIDELINES Kaichao Feng, Yang Liu, Yelei Guo, Jingdan Qiu, Zhiqiang

A comparative study of the vibro-impact capsule systems with one-sided and two-sided constraints

nonlinearities increases, the dynamics of the system will become more complex from periodic motion to chaos. Acknowledgements Dr. Yang Liu would like to acknowledge the financial support from EPSRC for his First

An epidemiological investigation of age-related macular degeneration in aged population in China: the Hainan study

Purpose The aim of this study was to investigate the prevalence of age-related macular degeneration (AMD) and the risk factors in the residents aged ≥50 years in Hainan Province. Methods Random sampling was carried out in four separated cities in Hainan Province in 2015. All the subjects accomplished the standard questionnaire and ocular examinations. The diagnosis of AMD was ...

Controlling multistability in a vibro-impact capsule system

This work concerns the control of multistability in a vibro-impact capsule system driven by a harmonic excitation. The capsule is able to move forward and backward in a rectilinear direction, and the main objective of this work is to control such motion in the presence of multiple coexisting periodic solutions. A position feedback controller is employed in this study, and our ...

Magnetic drug delivery systems

FUNCTIONALIZATION OF MAGNETIC NANOPARTICLES FOR TARGETING IN VIVO”. Yang F revised the manuscript. All authors participated in the discussion about the overall manuscript. Yang Liu received his BSc degree from

Some determinantal inequalities for Hadamard and Fan products of matrices

. Competing interests The authors declare to have no competing interests. Authors’ contributions Xiaohui Fu carried out all the proofs of the results and gave the generalizations of Fan product. Yang Liu

Degradable, absorbable or resorbable—what is the best grammatical modifier for an implant that is eventually absorbed by the body?

revised the manuscript. All authors participated in the discussion. Yang Liu received his bachelor degree in materials science and engineering from Harbin engineering University in 2013. Then he continued

Isolation of nontuberculous mycobacteria from soil using Middlebrook 7H10 agar with increased malachite green concentration

Environmental exposure is considered to be responsible for nontuberculous mycobacterial infections in humans. To facilitate the isolation of mycobacteria from soil, Middlebrook 7H10 agar was optimized as an enhanced selective medium by increasing the concentration of malachite green. A series of modified Middlebrook 7H10 agar media with malachite green concentrations ranging from ...

Comparisons of oncological and functional outcomes among radical retropubic prostatectomy, high dose rate brachytherapy, cryoablation and high-intensity focused ultrasound for localized prostate cancer

Purpose To conduct a retrospective, single institutional and comparative study for radical retropubic prostatectomy (RRP), high dose rate brachytherapy (HDRBT), cryoablation and high-intensity focused ultrasound (HIFU) in localized prostate cancer with respect to oncological and functional outcomes. Methods We reviewed 97, 161, 114 and 120 patients of RRP, HDRBT, cryoablation and ...

MRT precoding in downlink multi-user MIMO systems

This paper focuses on the design of maximum ratio transmission (MRT) precoding for multi-user multiple-input multiple-output (MU-MIMO) downlink transmission. Exiting block diagonalization (BD) precoding studies on MU-MIMO systems have the high complexity, because the transmitter precoding matrices constructed by singular value decomposition (SVD) are successively calculated twice. ...

Recent advancements in optical microstructure fabrication through glass molding process

Optical microstructures are increasingly applied in several fields, such as optical systems, precision measurement, and microfluid chips. Microstructures include microgrooves, microprisms, and microlenses. This paper presents an overview of optical microstructure fabrication through glass molding and highlights the applications of optical microstructures in mold fabrication and ...

An unusual combined thymic carcinoma composed of squamous cell carcinoma and type AB thymoma: a rare case report

Background Combined thymic carcinoma is a malignant neoplasm of the thymus recently added to the 4th edition of the World Health Organization (WHO) classification of tumors of the lung, pleura, thymus and heart. It involves at least one type of thymic carcinoma and another thymic epithelial tumor. The previously used term “combined thymic epithelial tumor” has been abandoned. Case ...

Anisotropic Magnetoresistance of Nano-conductive Filament in Co/HfO2/Pt Resistive Switching Memory

Conductive bridge random access memory (CBRAM) has been extensively studied as a next-generation non-volatile memory. The conductive filament (CF) shows rich physical effects such as conductance quantization and magnetic effect. But so far, the study of filaments is not very sufficient. In this work, Co/HfO2/Pt CBRAM device with magnetic CF was designed and fabricated. By ...

Buy-back and Revenue-Sharing Contracts in Global Supply Chain

Purpose: The main propose of this study is to investigate how exchange rate risk affects the buy-back and revenue-sharing contracts in the global supply chain, hence to improve the performance of global supply chain. Design/methodology/approach: Based on a two-echelon global supply chain, with the model equilibrium, this paper studies the difference between the buy-back contract ...

Simultaneous analyses of N-linked and O-linked glycans of ovarian cancer cells using solid-phase chemoenzymatic method

Background Glycans play critical roles in a number of biological activities. Two common types of glycans, N-linked and O-linked, have been extensively analyzed in the last decades. N-glycans are typically released from glycoproteins by enzymes, while O-glycans are released from glycoproteins by chemical methods. It is important to identify and quantify both N- and O-linked glycans ...

Chronic kidney disease and risk factor prevalence in Saint Kitts and Nevis: a cross-sectional study

Background The prevalence of chronic kidney disease (CKD) in St. Kitts and Nevis, islands of the West Indies, is unknown. We sought to determine estimates of CKD and its risk factors (e.g. diabetes, hypertension and obesity) in St. Kitts and Nevis. Methods This was a chronic disease screening program. Three community-based locations in St. Kitts and Nevis were included in the ...

Long life rechargeable Li-O2 batteries enabled by enhanced charge transfer in nanocable-like Fe@N-doped carbon nanotube catalyst

Rechargeable Li-O2 batteries have attracted considerable interests because of their exceptional energy density. However, the short lifetime still remained as one of the bottle-neck obstacles for the practical application of rechargeable Li-O2 batteries. The development of efficient cathode catalyst is highly desirable to reduce the energy barrier of Li-O2 reaction and electrode ...