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Promoting cross-border knowledge transfer for new product development in MNCs: a process view

Cross-border knowledge transfer plays an important role in the competitive advantage of multinational corporations (MNCs). However, it can be quite challenging due to cultural differences and lack of trust between organizational units located in different countries. Prior studies have not explored the knowledge transfer process (and its key nodes) in new product development in ...

Peripheral immune tolerance alleviates the intracranial lipopolysaccharide injection-induced neuroinflammation and protects the dopaminergic neurons from neuroinflammation-related neurotoxicity

Neuroinflammation plays a critical role in the onset and development of neurodegeneration disorders such as Parkinson’s disease. The immune activities of the central nervous system are profoundly affected by peripheral immune activities. Immune tolerance refers to the unresponsiveness of the immune system to continuous or repeated stimulation to avoid excessive inflammation and ...

Optimizing Non-Decomposable Evaluation Metrics for Neural Machine Translation

While optimizing model parameters with respect to evaluation metrics has recently proven to benefit end to-end neural machine translation (NMT), the evaluation metrics used in the training are restricted to be defined at the sentence level to facilitate online learning algorithms. This is undesirable because the final evaluation metrics used in the testing phase are usually ...

A comparative study of the vibro-impact capsule systems with one-sided and two-sided constraints

nonlinearities increases, the dynamics of the system will become more complex from periodic motion to chaos. Acknowledgements Dr. Yang Liu would like to acknowledge the financial support from EPSRC for his First

Comparison of the outcomes between thoracoscopic and laparoscopic esophagectomy via retrosternal and prevertebral lifting paths by the same surgeon

The objective of the study is to explore the effects of retrosternal and prevertebral lifting paths of the tubular stomach on postoperative complications of patients undergoing cervical anastomosis in thoracoscopic and laparoscopic esophagectomy. Sixty-three patients were retrospectively analyzed. The patients received thoracoscopic and laparoscopic esophagectomy by the same ...

Controlling multistability in a vibro-impact capsule system

This work concerns the control of multistability in a vibro-impact capsule system driven by a harmonic excitation. The capsule is able to move forward and backward in a rectilinear direction, and the main objective of this work is to control such motion in the presence of multiple coexisting periodic solutions. A position feedback controller is employed in this study, and our ...

Analysis of novel RUNX2 mutations in Chinese patients with cleidocranial dysplasia

Cleidocranial dysplasia (CCD) is an autosomal dominant inheritable skeletal disorder characterized by cranial dysplasia, clavicle hypoplasia and dental abnormalities. This disease is mainly caused by heterozygous mutations in RUNX2, a gene that encodes an osteoblast-specific transcription factor. In the present study, mutational analyses of RUNX2 gene were performed on four ...

Effect of naringin on gp120-induced injury mediated by P2X7 receptors in rat primary cultured microglia

Tao, Chenglong Liu, Zeyu Deng, Yang Liu, Guoqiao Chen, Baoyun Liu, Changshui Xu. Funding acquisition: Changshui Xu. Investigation: Hui Wu, Jia Tao, Chenglong Liu, Zeyu Deng, Yang Liu, Guoqiao Chen ... , Baoyun Liu, Changshui Xu. Methodology: Qiang Chen, Hui Wu, Jia Tao, Changshui Xu. Project administration: Jia Tao, Changshui Xu. Resources: Hui Wu, Yang Liu, Changshui Xu. Software: Changshui Xu

Some determinantal inequalities for Hadamard and Fan products of matrices

. Competing interests The authors declare to have no competing interests. Authors’ contributions Xiaohui Fu carried out all the proofs of the results and gave the generalizations of Fan product. Yang Liu

Assessing medical professionalism: A systematic review of instruments and their measurement properties

Background Over the last three decades, various instruments were developed and employed to assess medical professionalism, but their measurement properties have yet to be fully evaluated. This study aimed to systematically evaluate these instruments’ measurement properties and the methodological quality of their related studies within a universally acceptable standardized framework ...

Candidate odorant binding proteins and chemosensory proteins in the larval chemosensory tissues of two closely related noctuidae moths, Helicoverpa armigera and H. assulta

In order to acquire enough nutrients and energy for further development, larvae need to invest a large portion of their sensory equipments to identify food sources. Yet, the molecular basis of odor-driven behavior in larvae has been poorly investigated. Information on olfactory genes, particularly odorant binding proteins (OBPs) and chemosensory proteins (CSPs) which are involved ...

Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers

CART-HER2 cell infusion, and 2 cases of grade 1-2 HER2; CART; biliary tract cancers; pancreatic cancers; clinical trial - Kaichao Feng, Yang Liu and Yelei Guo contributed equally to this study ... ; TNF-alpha, tumor necrosis factor- alpha; Tregs, regulatory T cells; VEGF, vascular endothelial growth factor. COMPLIANCE WITH ETHICS GUIDELINES Kaichao Feng, Yang Liu, Yelei Guo, Jingdan Qiu, Zhiqiang

Construction and analyses of the microRNA-target gene differential regulatory network in thyroid carcinoma

Thyroid-carcinoma (THCA) is the most common malignancy with an increasing incidence. Recent evidence has emphasized the role of microRNA (miRNA) in THCA. However, knowledge concerning the roles of miRNAs in THCA is still limited. We therefore use a miRNA-target gene differential regulatory network (MGDRN) to identify key miRNAs and characterize their synergistic regulation in THCA. ...

An epidemiological investigation of age-related macular degeneration in aged population in China: the Hainan study

Purpose The aim of this study was to investigate the prevalence of age-related macular degeneration (AMD) and the risk factors in the residents aged ≥50 years in Hainan Province. Methods Random sampling was carried out in four separated cities in Hainan Province in 2015. All the subjects accomplished the standard questionnaire and ocular examinations. The diagnosis of AMD was ...

Generalized min-max bound-based MRI pulse sequence design framework for wide-range T1 relaxometry: A case study on the tissue specific imaging sequence

This paper proposes a new design strategy for optimizing MRI pulse sequences for T1 relaxometry. The design strategy optimizes the pulse sequence parameters to minimize the maximum variance of unbiased T1 estimates over a range of T1 values using the Cramér-Rao bound. In contrast to prior sequences optimized for a single nominal T1 value, the optimized sequence using our ...

Effects of low light on photosynthetic properties, antioxidant enzyme activity, and anthocyanin accumulation in purple pak-choi (Brassica campestris ssp. Chinensis Makino)

Anthocyanins are secondary metabolites that contribute to red, blue, and purple colors in plants and are affected by light, but the effects of low light on the physiological responses of purple pak-choi plant leaves are still unclear. In this study, purple pak-choi seedlings were exposed to low light by shading with white gauze and black shading in a phytotron. The responses in ...

Comparisons of oncological and functional outcomes among radical retropubic prostatectomy, high dose rate brachytherapy, cryoablation and high-intensity focused ultrasound for localized prostate cancer

Purpose To conduct a retrospective, single institutional and comparative study for radical retropubic prostatectomy (RRP), high dose rate brachytherapy (HDRBT), cryoablation and high-intensity focused ultrasound (HIFU) in localized prostate cancer with respect to oncological and functional outcomes. Methods We reviewed 97, 161, 114 and 120 patients of RRP, HDRBT, cryoablation and ...

Degradable, absorbable or resorbable—what is the best grammatical modifier for an implant that is eventually absorbed by the body?

revised the manuscript. All authors participated in the discussion. Yang Liu received his bachelor degree in materials science and engineering from Harbin engineering University in 2013. Then he continued

Magnetic drug delivery systems

FUNCTIONALIZATION OF MAGNETIC NANOPARTICLES FOR TARGETING IN VIVO”. Yang F revised the manuscript. All authors participated in the discussion about the overall manuscript. Yang Liu received his BSc degree from

Buy-back and Revenue-Sharing Contracts in Global Supply Chain

Purpose: The main propose of this study is to investigate how exchange rate risk affects the buy-back and revenue-sharing contracts in the global supply chain, hence to improve the performance of global supply chain. Design/methodology/approach: Based on a two-echelon global supply chain, with the model equilibrium, this paper studies the difference between the buy-back contract ...