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31 papers found.
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Novel Door-opening Method for Six-legged Robots Based on Only Force Sensing

, design and manufactory of nuclear power equipment, legged robots design and control. E-mail: Yang Pan, born in 1988, is currently working in Shanghai GQY Robot Limited Company, Shanghai, China. He

Comparative study on two civil engine thrust reversers for their maintainability analysis

Trade-offs studies on two kinds of existing engine thrust reverser design were carried out, applying virtual maintenance method and the basic theory of ergonomics. Analysis on the maintainability of the two kinds of configurations, the O-duct thrust reverser owning the integrated propulsion system (IPS) and the traditional portal D-duct thrust reverser, were compared. According...

Clinical and Immunological Effects of rhIL-2 Therapy in Eastern Chinese Patients with Multidrug-resistant Tuberculosis

, Nanjing, 210029, ChinaJun XiaDepartment of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaShi-yang Pan AuthorsSearch for Qi Tan in:Nature Research journals ... Search for Jun Xia in:Nature Research journals • PubMed • Google Scholar Search for Shi-yang Pan in:Nature Research journals • PubMed • Google Scholar Search for Huang Mao in:Nature Research journals

Cysteine protects rabbit spermatozoa against reactive oxygen species-induced damages

. Data curation: Zhendong Zhu, Xiaoteng Fan. Formal analysis: Zhendong Zhu, Zhanjun Ren, Yang Pan, Chuanying Pan. Funding acquisition: Zhanjun Ren. Investigation: Zhendong Zhu. Methodology: Shan Lv ... , Wenxian Zeng. Project administration: Wenxian Zeng. Resources: Zhanjun Ren, Anmin Lei. Software: Xiaoteng Fan, Yang Pan, Shan Lv. Writing ± original draft: Zhendong Zhu. Writing ± review & editing

Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test

Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the...

Development of an MDO platform for aero-structural interactions

An interactive MDO platform for multivariate and high coupling aero-structural interactions is presented in this paper. Programs based on RSM and GA are utilized as optimization solver, which is connected with CAD/CAE software by a friendly GUI. To generate and modify CAD models in the analysis and optimization process, CATIA Automation Technique is adopted to create a CAD model...

Effects of Solvent and Ion Source Pressure on the Analysis of Anabolic Steroids by Low Pressure Photoionization Mass Spectrometry

Solvent and ion source pressure were two important factors relating to the photon induced ion-molecule reactions in low pressure photoionization (LPPI). In this work, four anabolic steroids were analyzed by LPPI mass spectrometry. Both the ion species present and their relative abundances could be controlled by switching the solvent and adjusting the ion source pressure. Whereas...

Performances of Different Fragment Sizes for Reduced Representation Bisulfite Sequencing in Pigs

Background Reduced representation bisulfite sequencing (RRBS) has been widely used to profile genome-scale DNA methylation in mammalian genomes. However, the applications and technical performances of RRBS with different fragment sizes have not been systematically reported in pigs, which serve as one of the important biomedical models for humans. The aims of this study were to...

Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids

, United States of AmericaQing PanMcCormick Genomic and Proteomic Center, The George Washington University, Washington, DC 20037, United States of AmericaRaja Mazumder AuthorsSearch for Yang Pan in:Nature

Human germline and pan-cancer variomes and their distinct functional profiles

Identification of non-synonymous single nucleotide variations (nsSNVs) has exponentially increased due to advances in Next-Generation Sequencing technologies. The functional impacts of these variations have been difficult to ascertain because the corresponding knowledge about sequence functional sites is quite fragmented. It is clear that mapping of variations to sequence...

Spectral and mode properties of surface plasmon polariton waveguides studied by near-field excitation and leakage-mode radiation measurement

We present a method to couple surface plasmon polariton (SPP) guiding mode into dielectric-loaded SPP waveguide (DLSPPW) devices with spectral and mode selectivity. The method combined a transmission-mode near-field spectroscopy to excite the SPP mode and a leakage radiation optical microscope for direct visualization. By using a near-field fiber tip, incident photons with...

A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs

Background We have previously suggested a method for proteome wide analysis of variation at functional residues wherein we identified the set of all human genes with nonsynonymous single nucleotide variation (nsSNV) in the active site residue of the corresponding proteins. 34 of these proteins were shown to have a 1:1:1 enzyme:pathway:reaction relationship, making these proteins...

BioXpress: an integrated RNA-seq-derived gene expression database for pan-cancer analysis

BioXpress is a gene expression and cancer association database in which the expression levels are mapped to genes using RNA-seq data obtained from The Cancer Genome Atlas, International Cancer Genome Consortium, Expression Atlas and publications. The BioXpress database includes expression data from 64 cancer types, 6361 patients and 17 469 genes with 9513 of the genes displaying...

A framework for organizing cancer-related variations from existing databases, publications and NGS data using a High-performance Integrated Virtual Environment (HIVE)

Years of sequence feature curation by UniProtKB/Swiss-Prot, PIR-PSD, NCBI-CDD, RefSeq and other database biocurators has led to a rich repository of information on functional sites of genes and proteins. This information along with variation-related annotation can be used to scan human short sequence reads from next-generation sequencing (NGS) pipelines for presence of non...

Influence of the Angiotensin Converting Enzyme Insertion or Deletion Genetic Variant and Coronary Restenosis Risk: Evidence Based on 11,193 Subjects

The insertion/deletion (I/D) polymorphism of the gene encoding angiotensin converting enzyme is a controversial risk factor for restenosis after percutaneous transluminal coronary angioplasties (PTCA) in patients. Genetic association studies can be problematic to reproduce due to insufficient power, phenotypic heterogeneity, population stratification, small effect of the variant...

miR-638 is a new biomarker for outcome prediction of non-small cell lung cancer patients receiving chemotherapy

Huang in:Nature Research journals • PubMed • Google ScholarSearch for Shi-yang Pan in:Nature Research journals • PubMed • Google ScholarSearch for Hong Wang in:Nature Research journals • PubMed • Google ... Scholar Competing interests The authors declare no conflict of interest. Corresponding authors Correspondence to Shi-yang Pan or Hong Wang. Rights and permissions This work is licensed under a Creative

Identification of EBV infection in adults with egg specific food allergy

Background Food allergy has been reported increasingly around the world during the past several decades. Epstein-Barr virus (EBV), a common herpesvirus with high infection rate, is now suspected to be a risk or protective factor in food allergy. The aim of the study was to investigate the possible role of EBV infection in IgE-mediated food allergy. Methods 34 patients with an egg...

MS2 VLP-based delivery of microRNA-146a inhibits autoantibody production in lupus-prone mice

MS2 VLP-based delivery of microRNA-146a inhibits autoantibody production in lupus-prone mice Yang Pan,1,2 Tingting Jia,1,2 Yuan Zhang,1,2 Kuo Zhang,1 Rui Zhang,1 Jinming Li,1 Lunan Wang11National

High-performance integrated virtual environment (HIVE): a robust infrastructure for next-generation sequence data analysis

The High-performance Integrated Virtual Environment (HIVE) is a distributed storage and compute environment designed primarily to handle next-generation sequencing (NGS) data. This multicomponent cloud infrastructure provides secure web access for authorized users to deposit, retrieve, annotate and compute on NGS data, and to analyse the outcomes using web interface visual...

Generating a focused view of disease ontology cancer terms for pan-cancer data integration and analysis

Bio-ontologies provide terminologies for the scientific community to describe biomedical entities in a standardized manner. There are multiple initiatives that are developing biomedical terminologies for the purpose of providing better annotation, data integration and mining capabilities. Terminology resources devised for multiple purposes inherently diverge in content and...