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21 papers found.
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Novel Door-opening Method for Six-legged Robots Based on Only Force Sensing

, design and manufactory of nuclear power equipment, legged robots design and control. E-mail: Yang Pan, born in 1988, is currently working in Shanghai GQY Robot Limited Company, Shanghai, China. He

Cysteine protects rabbit spermatozoa against reactive oxygen species-induced damages

. Data curation: Zhendong Zhu, Xiaoteng Fan. Formal analysis: Zhendong Zhu, Zhanjun Ren, Yang Pan, Chuanying Pan. Funding acquisition: Zhanjun Ren. Investigation: Zhendong Zhu. Methodology: Shan Lv ... , Wenxian Zeng. Project administration: Wenxian Zeng. Resources: Zhanjun Ren, Anmin Lei. Software: Xiaoteng Fan, Yang Pan, Shan Lv. Writing ± original draft: Zhendong Zhu. Writing ± review & editing

Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test

Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the...

Effects of Solvent and Ion Source Pressure on the Analysis of Anabolic Steroids by Low Pressure Photoionization Mass Spectrometry

Solvent and ion source pressure were two important factors relating to the photon induced ion-molecule reactions in low pressure photoionization (LPPI). In this work, four anabolic steroids were analyzed by LPPI mass spectrometry. Both the ion species present and their relative abundances could be controlled by switching the solvent and adjusting the ion source pressure. Whereas...

Performances of Different Fragment Sizes for Reduced Representation Bisulfite Sequencing in Pigs

Background Reduced representation bisulfite sequencing (RRBS) has been widely used to profile genome-scale DNA methylation in mammalian genomes. However, the applications and technical performances of RRBS with different fragment sizes have not been systematically reported in pigs, which serve as one of the important biomedical models for humans. The aims of this study were to...

Human germline and pan-cancer variomes and their distinct functional profiles

Identification of non-synonymous single nucleotide variations (nsSNVs) has exponentially increased due to advances in Next-Generation Sequencing technologies. The functional impacts of these variations have been difficult to ascertain because the corresponding knowledge about sequence functional sites is quite fragmented. It is clear that mapping of variations to sequence...

Spectral and mode properties of surface plasmon polariton waveguides studied by near-field excitation and leakage-mode radiation measurement

We present a method to couple surface plasmon polariton (SPP) guiding mode into dielectric-loaded SPP waveguide (DLSPPW) devices with spectral and mode selectivity. The method combined a transmission-mode near-field spectroscopy to excite the SPP mode and a leakage radiation optical microscope for direct visualization. By using a near-field fiber tip, incident photons with...

BioXpress: an integrated RNA-seq-derived gene expression database for pan-cancer analysis

BioXpress is a gene expression and cancer association database in which the expression levels are mapped to genes using RNA-seq data obtained from The Cancer Genome Atlas, International Cancer Genome Consortium, Expression Atlas and publications. The BioXpress database includes expression data from 64 cancer types, 6361 patients and 17 469 genes with 9513 of the genes displaying...

A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs

Background We have previously suggested a method for proteome wide analysis of variation at functional residues wherein we identified the set of all human genes with nonsynonymous single nucleotide variation (nsSNV) in the active site residue of the corresponding proteins. 34 of these proteins were shown to have a 1:1:1 enzyme:pathway:reaction relationship, making these proteins...

A framework for organizing cancer-related variations from existing databases, publications and NGS data using a High-performance Integrated Virtual Environment (HIVE)

Years of sequence feature curation by UniProtKB/Swiss-Prot, PIR-PSD, NCBI-CDD, RefSeq and other database biocurators has led to a rich repository of information on functional sites of genes and proteins. This information along with variation-related annotation can be used to scan human short sequence reads from next-generation sequencing (NGS) pipelines for presence of non...

Influence of the Angiotensin Converting Enzyme Insertion or Deletion Genetic Variant and Coronary Restenosis Risk: Evidence Based on 11,193 Subjects

The insertion/deletion (I/D) polymorphism of the gene encoding angiotensin converting enzyme is a controversial risk factor for restenosis after percutaneous transluminal coronary angioplasties (PTCA) in patients. Genetic association studies can be problematic to reproduce due to insufficient power, phenotypic heterogeneity, population stratification, small effect of the variant...

High-performance integrated virtual environment (HIVE): a robust infrastructure for next-generation sequence data analysis

The High-performance Integrated Virtual Environment (HIVE) is a distributed storage and compute environment designed primarily to handle next-generation sequencing (NGS) data. This multicomponent cloud infrastructure provides secure web access for authorized users to deposit, retrieve, annotate and compute on NGS data, and to analyse the outcomes using web interface visual...

Identification of EBV infection in adults with egg specific food allergy

Background Food allergy has been reported increasingly around the world during the past several decades. Epstein-Barr virus (EBV), a common herpesvirus with high infection rate, is now suspected to be a risk or protective factor in food allergy. The aim of the study was to investigate the possible role of EBV infection in IgE-mediated food allergy. Methods 34 patients with an egg...

Generating a focused view of disease ontology cancer terms for pan-cancer data integration and analysis

Bio-ontologies provide terminologies for the scientific community to describe biomedical entities in a standardized manner. There are multiple initiatives that are developing biomedical terminologies for the purpose of providing better annotation, data integration and mining capabilities. Terminology resources devised for multiple purposes inherently diverge in content and...

Non-synonymous variations in cancer and their effects on the human proteome: workflow for NGS data biocuration and proteome-wide analysis of TCGA data

Background Next-generation sequencing (NGS) technologies have resulted in petabytes of scattered data, decentralized in archives, databases and sometimes in isolated hard-disks which are inaccessible for browsing and analysis. It is expected that curated secondary databases will help organize some of this Big Data thereby allowing users better navigate, search and compute on it...

Electrospray/VUV single-photon ionization mass spectrometry for the analysis of organic compounds

For the comprehensive analysis of organic compounds, especially thermal labile and nonpolar compounds, an electrospray/vacuum ultraviolet (VUV) single-photon ionization (ES-SPI) method was developed. The fine droplets of the sample solution from the electrospray process were directed through a quartz capillary and two skimmers to form a molecular beam into a high vacuum...

Autoantibodies against the Catalytic Domain of BRAF Are Not Specific Serum Markers for Rheumatoid Arthritis

Background Autoantibodies to the catalytic domain of v-raf murine sarcoma viral oncogene homologue B1 (BRAF) have been recently identified as a new family of autoantibodies involved in rheumatoid arthritis (RA). The objective of this study was to determine antibody responses to the catalytic domain of BRAF in RA and other autoimmune diseases. The association between RA-related...

Poly (I:C), an agonist of toll-like receptor-3, inhibits replication of the Chikungunya virus in BEAS-2B cells

Background Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-β in many cell types. Poly (I:C) is the most potent IFN inducer. In in vivo mouse studies, intraperitoneal injection of Poly (I:C) elicited IFN-α/β production and natural killer (NK) cells activation...

A Summer Outbreak of Human Metapneumovirus Infection in a Long-Term-Care Facility

Human metapneumovirus (hMPV), a recently discovered paramyxovirus, is thought to be primarily a winter-spring pathogen affecting young children with a clinical presentation similar to that of respiratory syncytial virus. In June–July 2006, a respiratory outbreak in a long-term-care facility was reported to the local health department and investigated. Surveillance identified 26...

Induction of Fibroblast Growth Factor-9 and Interleukin-1α Gene Expression by Motorcycle Exhaust Particulate Extracts and Benzo(a)pyrene in Human Lung Adenocarcinoma Cells

Motorcycle exhaust particulates (MEP) contain carcinogenic polycyclic aromatic hydrocarbons including benzo(a)pyrene. This study has determined the ability of MEP to alter the expression of select genes from drug metabolism, cytokine, oncogene, tumor suppressor, and estrogen signaling families of human lung adenocarcinoma CL5 cells. cDNA microarray analyses and confirmation...