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Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age

Previous studies of singletons evaluating prenatal phthalate exposure and early neurodevelopment reported mixed results and the associations could be biased by parental, obstetrical, and genetic factors. A co-twin control design was employed to test whether prenatal phthalate exposure was associated with children’s neurocognitive development. We collected information from 97...

Nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer

As of 2020, hepatocellular carcinoma (HCC), a form of liver cancer, stood as the third most prominent contributor to global cancer-related mortality. Combining immune checkpoint inhibitors (ICI) with other therapies has shown promising results for treating unresectable HCC, offering new opportunities. Recombinant adeno-associated viral type 2 (AAV2) virotherapy has been approved...

Study on the dynamic pore water pressure model of centerline tailings sand based on dynamic triaxial tests

The increase of pore water pressure under a dynamic load is an important reason for the vibration liquefaction of saturated sand. Therefore, studying the dynamic pore water pressure model of tailings sand plays an important role in the seismic liquefaction analysis of tailings ponds. In this paper, the dynamic pore water pressure development characteristics of tailings fine sand...

Does cone-beam computed tomography examination increase the micronuclei frequency in the oral mucosa exfoliated cells? A systematic review and meta-analysis

This systematic review (SR) with meta-analysis aimed to evaluate the frequency of micronuclei in the oral mucosa exfoliated cells after cone-beam computed tomography (CBCT) examination. We performed language-independent computer-assisted data searches using PubMed databases, Cochrane, Embase, Web of Science all databases, and Google Scholar. The literature on micronucleus (MN...

Exosomal long noncoding RNA MLETA1 promotes tumor progression and metastasis by regulating the miR-186-5p/EGFR and miR-497-5p/IGF1R axes in non-small cell lung cancer

Lung cancer is the most common and deadliest cancer worldwide, and approximately 90% of all lung cancer deaths are caused by tumor metastasis. Tumor-derived exosomes could potentially promote tumor metastasis through the delivery of metastasis-related molecules. However, the function and underlying mechanism of exosomal long noncoding RNA (lncRNA) in lung cancer metastasis remain...

Considering the Influence of Coronary Motion on Artery-Specific Biomechanics Using Fluid–Structure Interaction Simulation

The endothelium in the coronary arteries is subject to wall shear stress and vessel wall strain, which influences the biology of the arterial wall. This study presents vessel-specific fluid–structure interaction (FSI) models of three coronary arteries, using directly measured experimental geometries and boundary conditions. FSI models are used to provide a more physiologically...

Molecular and Morphological Engineering of Organic Electrode Materials for Electrochemical Energy Storage

Organic electrode materials (OEMs) can deliver remarkable battery performance for metal-ion batteries (MIBs) due to their unique molecular versatility, high flexibility, versatile structures, sustainable organic resources, and low environmental costs. Therefore, OEMs are promising, green alternatives to the traditional inorganic electrode materials used in state-of-the-art...

Preparation of Graphite-UiO-66(Zr)/Ti electrode for efficient electrochemical oxidation of tetracycline in water

, Fuqiang Liu, Chendong Shuang. Data curation: Bicun Jiang, Fuqiang Liu, Yang Pan, Yan Tan. Formal analysis: Bicun Jiang, Fuqiang Liu, Yang Pan, Yan Tan. Funding acquisition: Aimin Li. Investigation: Bicun ... Jiang, Yang Pan, Yan Tan. Methodology: Bicun Jiang, Fuqiang Liu, Chendong Shuang. Project administration: Fuqiang Liu, Chendong Shuang. Resources: Chendong Shuang, Aimin Li. Software: Yang Pan, Yan Tan

LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway

Long-form collapsin response mediator protein-1 (LCRMP-1) belongs to the CRMP family which comprises brain-enriched proteins responsible for axon guidance. However, its role in spermatogenesis remains unclear. Here we find that LCRMP-1 is abundantly expressed in the testis. To characterize its physiological function, we generate LCRMP-1-deficient mice (Lcrmp-1−/−). These mice...

Retroperitoneum ganglioneuroma: imaging features and surgical outcomes of 35 cases at a Chinese Institution

The preoperative evaluation is crucial for diagnosis and surgical plan of retroperitoneum ganglioneuroma (GN). In this study, we reviewed a relatively large series of histopathological proved retroperitoneum GN cases, summarized the imaging features and further depicted risk factors of increased surgical blood loss. A total of 35 (18 male, 17 female) patients were retrospectively...

Aspergillosis infection over 20 years: a case report of probable vascular invasion in central nervous system

/0000-0002-1525-23291, Xu Wu1 & Yang-Pan Hu1  BMC Neurology volume 20, Article number: 342 (2020) Cite this article 139 Accesses Metrics details Abstract Background Aspergillosis ... Hospital of Wuhan University, Wuhan, 430060, China Yong Zhang, Xu Wu & Yang-Pan Hu AuthorsYong Zhang View author publications You can also search for this author in PubMed Google Scholar Xu Wu View

Three-gene prognostic biomarkers for seminoma identified by weighted gene co-expression network analysis

, Xiaoxiang Jin. Resources: Hualin Chen, Xiaoxiang Jin. Software: Hualin Chen, Yang Pan, Xiaoxiang Jin. Supervision: Hualin Chen, Yang Pan. Validation: Hualin Chen, Yang Pan. Visualization: Hualin Chen, Yang ... Pan. Writing – original draft: Hualin Chen. Writing – review & editing: Hualin Chen, Gang Chen. 12 / 14 10. 13 / 14 1. Chen Y-H , Lin T-T , Wu Y-P , Li X-D , Chen S-H , Xue X-Y , et al

Association between housing environment and depressive symptoms among older people: a multidimensional assessment

Depression is a common mental disorder among older people. This study aimed to assess the association between housing environment factors and depressive symptoms among older people using a multidimensional assessment method. The study uses a population-based cross-sectional design. A total of 950 participants aged ≥ 60 years were selected using a complex multistage sampling...

Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice

Lipophilic statins which are blood brain barrier (BBB) permeable are speculated to affect the cholesterol synthesis and neural functions in the central nervous system. However, whether these statins can affect cholesterol levels and synaptic plasticity in hippocampus and the in vivo consequence remain unclear. Here, we report that long-term subcutaneous treatments of simvastatin...

In vivo evaluation of additively manufactured multi-layered scaffold for the repair of large osteochondral defects

The repair of osteochondral defects is one of the major clinical challenges in orthopaedics. Well-established osteochondral tissue engineering methods have shown promising results for the early treatment of small defects. However, less success has been achieved for the regeneration of large defects, which is mainly due to the mechanical environment of the joint and the...

The left ureterocele and stone of calyceal diverticulum in the patient with bilateral incomplete duplex kidneys managed by flexible ureteroscopy: a case report and literature review

Duplex kidneys are one of the most common renal congenital abnormalities, mostly asymptomatic and of no clinical significance. There are little reports about the left ureterocele and stone of calyceal diverticulum in patients with bilateral incomplete duplex kidneys managed by flexible ureteroscopy. A 69-year-old Chinese woman was presented with left waist pain for 1 month. A...

A PET imaging study of the brain changes of glucose metabolism in patients with temporal lobe epilepsy and depressive disorder

This study aims to compare the difference of the brain changes of glucose metabolism between temporal lobe epilepsy patients (TLE) with major depressive disorder and temporal TLE without major depressive disorder. A total of 24 TLE patients, who met the inclusion criteria of our hospital, were enrolled in this study. They were divided into a TLE with depression group (n = 11) and...

Abnormal Gray Matter Volume and Functional Connectivity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder

Research Article | Open Access Volume 2021 |Article ID 8851027 | https://doi.org/10.1155/2021/8851027 Xu Jiang, Zhuang Wu, Min Zhong, Bo Shen, Jun Zhu, Yang Pan, Jun Yan, Wenbin Zhang ... Disorder Xu Jiang,1 Zhuang Wu,1 Min Zhong,1 Bo Shen,1 Jun Zhu,1 Yang Pan,1 Jun Yan,1 Wenbin Zhang,2 Pingyi Xu,3 Chaoyong Xiao,4 and Li Zhang1 1Department of Geriatrics, Nanjing Brain Hospital Affiliated

Safety of the application of Rigidfix cross-pin system via different tibial tunnels for tibial fixation during anterior cruciate ligament reconstruction

We investigate the safety of the application of the Rigidfix cross-pin system via different tibial tunnels in the tibial fixation during anterior cruciate ligament (ACL) reconstruction. Five adult fresh cadaver knees were fixed with the Rigidfix cross-pins in the tibial fixation site during ACL reconstruction. Two different tibial tunnel groups were established: in group A, the...

Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses

A metal nanoparticle composite, namely TPNT1, which contains Au-NP (1 ppm), Ag-NP (5 ppm), ZnO-NP (60 ppm) and ClO2 (42.5 ppm) in aqueous solution was prepared and characterized by spectroscopy, transmission electron microscopy, dynamic light scattering analysis and potentiometric titration. Based on the in vitro cell-based assay, TPNT1 inhibited six major clades of severe acute...