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Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice

) Acknowledgments We thank Richard Tu for technical assistance on the animal surgical model. Author Contributions Conceptualization: Che-Chung Yeh, Yanying Fan, Paul C. Simpson, Michael J. Mann. Data curation ... : Che-Chung Yeh, Yanying Fan, Yanchun Xu, Yi-Lin Yang. Formal analysis: Che-Chung Yeh, Yanying Fan, Paul C. Simpson, Michael J. Mann. Funding acquisition: Michael J. Mann. Investigation: Yanying Fan

Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for normal cardiac development. We investigated the effect of active MEK1 overexpression on fetal atrial septal development. An inducible double transgenic (DTg) mouse model was ...

Limb Ischemic Preconditioning Protects Endothelium from Oxidative Stress by Enhancing Nrf2 Translocation and Upregulating Expression of Antioxidases

Remote ischemic preconditioning is often performed by limb ischemic preconditioning (LIPC), which has been demonstrated to be beneficial to various cells, including endothelial cells. The mechanisms underlying the protection have not been well clarified. The present study was designed to observe the effects of sera derived from rats after LIPC on human umbilical vein endothelial ...

Oxygen-Glucose Deprivation Induced Glial Scar-Like Change in Astrocytes

Background It has been demonstrated that cerebral ischemia induces astrocyte reactivity, and subsequent glial scar formation inhibits axonal regeneration during the recovery phase. Investigating the mechanism of glial scar formation will facilitate the development of strategies to improve axonal regeneration. However, an in vitro model of ischemia-induced glial scar has not yet ...