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A Novel, Patient-Specific Mathematical Pathology Approach for Assessment of Surgical Volume: Application to Ductal Carcinoma in situ of The Breast

Health Science Center , Houston, TX , USA 7 , Yao-Li Chuang We introduce a novel “mathematical pathology” approach, founded on a biophysical model, to identify robust patientspecific predictors of tumor

Morphology and molecular genetics reveal two new Leptobrachella species in southern China (Anura, Megophryidae)

Based on morphological and phylogenetic analyses (16S rRNA mtDNA), two new species of the genus Leptobrachella are described from southern China, namely L. yunkaiensis Wang, Li, Lyu & Wang, sp. n. from Dawuling Forest Station of Guangdong Province and L. wuhuangmontis Wang, Yang & Wang, sp. n. from Mt. Wuhuang of Guangxi Province. To date, the genus Leptobrachella contains 68...

Mechanical Properties and Acoustic Emission Characteristics of Karst Limestone under Uniaxial Compression

Firstly, I-RPT ultrasonic detector was used to test the wave velocity of karst limestone with different initial microstructure and water content. Then, RMT-150B rock testing machine and DS2-16B acoustic emission system were used to test the acoustic emission (AE) under uniaxial compression. Mechanical properties and AE characteristics were obtained during rock failure. The...

Biodegradation of decabromodiphenyl ether (BDE 209) by a newly isolated bacterium from an e-waste recycling area

Polybrominated diphenyl ethers (PBDEs) have become widespread environmental pollutants all over the world. A newly isolated bacterium from an e-waste recycling area, Stenotrophomonas sp. strain WZN-1, can degrade decabromodiphenyl ether (BDE 209) effectively under aerobic conditions. Orthogonal test results showed that the optimum conditions for BDE 209 biodegradation were pH 5...

Electroacupuncture Improves Gastric Emptying in Critically Ill Neurosurgical Patients: A Pilot Study

conflicts of interest. Authors’ Contributions Man-Ling Kao, Yao-Li Chen, Ping-Yi Lin, and Sung-Yen Huang designed the study. Shu-Ching Lee and Sung-Yen Huang performed the experiments. Man-Ling Kao and Yao-Li

Molecular Dynamics Modeling and Simulation of Diamond Cutting of Cerium

The coupling between structural phase transformations and dislocations induces challenges in understanding the deformation behavior of metallic cerium at the nanoscale. In the present work, we elucidate the underlying mechanism of cerium under ultra-precision diamond cutting by means of molecular dynamics modeling and simulations. The molecular dynamics model of diamond cutting...

An androgen reduced transcript of LncRNA GAS5 promoted prostate cancer proliferation

Contributions Conceptualization: Yingyi Zhang, Xinya Su, Xuechao Wan, Yao Li. Data curation: Yingyi Zhang, Xinya Su, Dan Wang. 10 / 12 Formal analysis: Yingyi Zhang, Xinya Su. Investigation: Yingyi Zhang

Hemodynamic effects of intraoperative anesthetics administration in photothrombotic stroke model: a study using laser speckle imaging

Background Previous neuroimaging studies have shown the hemodynamic effect of either preconditioning or postconditioning anesthesia in ischemic stroke model. However, the anesthetic effect in hemodynamics during and immediately after the stroke modeling surgery remains unknown due to the lack of appropriate anesthesia-free stroke model and intraoperative imaging technology. In...

SemDiff: Finding Semtic Differences in Binary Programs based on Angr

We introduce SemDiff, a novel technology for finding semantic differences between two binary files. Now, the vendor will release the information to patch the previous version which has vulnerability. Then, we can compare the differences and similarities between the two versions to get the unpublished details of the 1day vulnerabilities. Tools, such as BinDiff, BinHunt and...

SemDiff: Finding Semtic Differences in Binary Programs based on Angr

We introduce SemDiff, a novel technology for finding semantic differences between two binary files. Now, the vendor will release the information to patch the previous version which has vulnerability. Then, we can compare the differences and similarities between the two versions to get the unpublished details of the 1day vulnerabilities. Tools, such as BinDiff, BinHunt and...

The value of Gd-EOB-DTPA-enhanced MR imaging in characterizing cirrhotic nodules with atypical enhancement on Gd-DTPA-enhanced MR images

Purpose To evaluate the utility of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) in characterizing atypically enhanced cirrhotic nodules detected on conventional Gd-DTPA-enhanced MR images. Materials and methods We enrolled 61 consecutive patients with 88 atypical nodules seen on conventional Gd-DTPA-enhanced MR images who underwent Gd-EOB-DTPA-enhanced MRI within a 3...

Effects of social support, hope and resilience on quality of life among Chinese bladder cancer patients: a cross-sectional study

Background Improvement of quality of life has been one of goals in health care for people living with bladder cancer. Meanwhile, positive psycho-social variables in oncology field have increasingly received attention. However, the assessment of quality of life of bladder cancer patients and the integrative effects of positive psycho-social variables has limited reporting. The aim...

Electrical Stimulation of Coleopteran Muscle for Initiating Flight

Some researchers have long been interested in reconstructing natural insects into steerable robots or vehicles. However, until recently, these so-called cyborg insects, biobots, or living machines existed only in science fiction. Owing to recent advances in nano/micro manufacturing, data processing, and anatomical and physiological biology, we can now stimulate living insects to...

Roles of microRNA and signaling pathway in osteoarthritis pathogenesis

for diagnosis and treatment of OA. Compliance with ethics guidelines Bin XU, Yao-yao LI, Jun MA, and Fu-xing PEI declare that they have no conflicts of interest. The article does not contain any

Sox9 transcriptionally regulates Wnt signaling in intestinal epithelial stem cells in hypomethylated crypts in the diabetic state

Background Distinctive structures called crypts harbor intestinal epithelial stem cells (IESCs) which generate progenitor and terminally differentiated cells in the intestinal epithelium. Mammalian IESCs and their daughter cells require the participation of DNA methylation and the transcription factor Sox9 for proliferation and differentiation. However, the association between...

A new hope for patients suffering from multiple myeloma

Multiple myeloma is a common hematological malignancy that leads to the occurrence of bone lesions. The combination of traditional cytotoxic and novel agents is usually taken to treat multiple myeloma-related bone diseases. However, the curative effect is not very satisfactory. Stem cell-based therapy has been recently introduced and investigated, which represents a new frontier...

Members of WRKY Group III transcription factors are important in TYLCV defense signaling pathway in tomato (Solanum lycopersicum)

Background Transmitted by the whitefly Bemisia tabaci, tomato yellow leaf curly virus (TYLCV) has posed serious threats to plant growth and development. Plant innate immune systems against various threats involve WRKY Group III transcription factors (TFs). This group participates as a major component of biological processes in plants. Results In this study, 6 WRKY Group III TFs...

Psychological Disorders and Psychosocial Resources of Patients with Newly Diagnosed Bladder and Kidney Cancer: A Cross-Sectional Study

Purpose Psychological disorders have been proven to be associated with poor physiological, psychological and immune outcomes in cancer patients. However, despite of many challenges of the changed self-image/body image and the altered sexual/urinary function, relatively little is known about psychological disorders of patients with newly diagnosed bladder and kidney cancer. We...

Plastic Change along the Intact Crossed Pathway in Acute Phase of Cerebral Ischemia Revealed by Optical Intrinsic Signal Imaging

The intact crossed pathway via which the contralesional hemisphere responds to the ipsilesional somatosensory input has shown to be affected by unilateral stroke. The aim of this study was to investigate the plasticity of the intact crossed pathway in response to different intensities of stimulation in a rodent photothrombotic stroke model. Using optical intrinsic signal imaging...

Comparison of gram-negative and gram-positive hematogenous pyogenic spondylodiscitis: clinical characteristics and outcomes of treatment

Background To the best of our knowledge, no study has compared gram-negative bacillary hematogenous pyogenic spondylodiscitis (GNB-HPS) with gram-positive coccal hematogenous pyogenic spondylodiscitis (GPC-HPS) regarding their clinical characteristics and outcomes. Methods From January 2003 to January 2013, 54 patients who underwent combined antibiotic and surgical therapy in the...