metaheuristic algorithms and verifying the proposed models with more comprehensive and real-world datasets. Author Contributions Formal analysis: Yao Peng. Funding acquisition: Yao Peng. Investigation: Yao ... Peng, Yang Chen. Supervision: Yao Peng. Validation: Yao Peng. 13 / 16 14 / 16 31. Wortmann T., et al. Are genetic algorithms really the best choice for building energy optimization? in Proceedings of
Preeclampsia is a life-threatening disease of pregnancy that lacks effective pharmaceuticals which can target its pathogenesis. Since preeclampsia involves complex pathological processes, including autophagy, this study aims to explore autophagy-related mechanisms of preeclampsia and to screen potential drugs. Firstly, the datasets GSE75010, GSE24129, GSE66273, and autophagic...
Pediatrics , Williford 7 Yao-Peng Xue 8 & Gautam Dantas 9 , Niraj H. Tolia Tetracycline destructases (TDases) are flavin monooxygenases which can confer resistance to all generations of tetracycline
Colorectal cancer is a common malignant tumour. Invasive growth and distant metastasis are the main characteristics of its malignant biological behaviour, and they are also the primary factors leading to death in colon cancer patients. Atovaquone is an antimalarial drug, and its anticancer effect has recently been demonstrated in several cancer models in vitro and in vivo, but it...
Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood. Here, we data-mined human and mouse heart ribosome profiling analyses and identified a double-stranded RNA (dsRNA) structure within the GATA4 uORF that cooperates with the start codon to augment uORF...
Serum globulin, which is composed mainly of immunoglobulins and acute phase proteins, can be considered as reflecting the inflammatory state. We conducted the present study to investigate the role of globulin in mortality risk in patients undergoing peritoneal dialysis (PD). The study participants were categorized by the median globulin value (2.8 g/dL) as the high globulin group...
Prognositic nutritional index (PNI), monocyte-to-lymphocyte ratio (MLR) and platelet (PLT) are associated with tumor survival in many human malignancies. Whereas, no study combined PNI-MLR-PLT score and indicated its predictive significance on the prognosis of patients with non-metastatic clear cell renal cell carcinoma (ccRCC). In this study, we retrospectively collected the...
Medical imaging is an important tool for accurate medical diagnosis, while state-of-the-art image reconstruction algorithms raise critical challenges in massive data processing for high-speed and high-quality imaging. Here, we present a memristive image reconstructor (MIR) to greatly accelerate image reconstruction with discrete Fourier transformation (DFT) by computing-in-memory...
Osteoimmunity plays an important role in the process of implant osseointegration. Autophagy is a conservative metabolic pathway of eukaryotic cells, but whether the interaction between autophagy and osteoimmunity plays a key role in osseointegration remains unclear. In this study, we prepared smooth titanium disks and micro-nano topography titanium disks, to study the immune...
There is increasing evidence showing that albumin–globulin ratio (AGR) can predict the survival of patients in many types of malignancies. However, no study was done to explore the value of AGR in peritoneal dialysis (PD) patients. A total of 554 incident patients undergoing PD from January 2001 through July 2016 were enrolled for this retrospective observational study. The...
Hardware implementation in resource-efficient reservoir computing is of great interest for neuromorphic engineering. Recently, various devices have been explored to implement hardware-based reservoirs. However, most studies were mainly focused on the reservoir layer, whereas an end-to-end reservoir architecture has yet to be developed. Here, we propose a versatile method for...
The human nervous system senses the physical world in an analogue but efficient way. As a crucial ability of the human brain, sound localization is a representative analogue computing task and often employed in virtual auditory systems. Different from well-demonstrated classification applications, all output neurons in localization tasks contribute to the predicted direction...
Hospital). Members of the Editorial Board. Yao-Peng Chen (the 923th Hospital of Joint Logistics Support Forces of Chinese PLA), Jing Dai (Ruijin Hospital Affiliated to Medical College of Shanghai Jiaotong ... -Peng Chen 6 Wei-Qin Li 1 Chinese Society of Thrombosis Hemostasis Critical Care Chinese Medicine Education Association 0 Department of Critical Care Medicine, the 908th Hospital of Joint Logistics
Background: The results have been inconsistent with regards to the impact of uric acid (UA) on clinical outcomes both in the general population and in patients with chronic kidney disease. The aim of this study was to study the influence of serum UA levels on mortality in patients undergoing continuous ambulatory peritoneal dialysis. Methods: Data on 492 patients from a single...
Background: Glucose is one of the constituents in hemodialysates and peritoneal dialysates. How the dialysis associates with the incident diabetes mellitus (DM) remains to be assessed. Methods: The claim data of end-stage renal disease (ESRD) patients who initiated dialysis from and a cohort of matched non-dialysis individuals from 2000 to 2013 were retrieved from the Taiwan...
Candida albicans is a commensal that inhabits the skin and mucous membranes of humans. Because of the increasing immunocompromised population and the limited classes of antifungal drugs available, C. albicans has emerged as an important opportunistic pathogen with high mortality rates. During infection and therapy, C. albicans frequently encounters immune cells and antifungal...
The class B family of G-protein-coupled receptors (GPCRs) has long been a paradigm for peptide hormone recognition and signal transduction. One class B GPCR, the glucagon-like peptide-1 receptor (GLP-1R), has been considered as an anti-diabetes drug target and there are several peptidic drugs available for the treatment of this overwhelming disease. The previously determined...
field samples’ collection. We thank Dr. Pierre Rivailler for critical reading of the manuscript. Author Contributions Conceptualization: Yao Peng, Jinxing Lu, Aiping Qin. Data curation: Yao Peng, Xiao ... Zheng, Aiping Qin. Formal analysis: Yao Peng, Xiao Zheng, Aiping Qin. Funding acquisition: Biao Kan, Jinxing Lu. Investigation: Yao Peng, Aiping Qin. Methodology: Yao Peng, Xiao Zheng, Aiping Qin
AffiliationsDivision of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, TaiwanChew-Teng Kor, Yao-Peng Hsieh, Chia-Chu Chang & Ping-Fang ChiuSchool of Medicine, Kaohsiung Medical ... Life Science, National Chung Hsing University, Taichung, TaiwanYao-Peng Hsieh AuthorsSearch for Chew-Teng Kor in:Nature Research journals • PubMed • Google Scholar Search for Yao-Peng Hsieh in:Nature