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Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation Han Wang,1–3 Yao Wang,1–3 Wentao Guo,4 Bin Du,1–3 Xiaobing ... Drug Design, Development and Therapy insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and Jh-Viii-157-02 caused by g1202r solvent front mutation han Wang 2 3 Yao Wang 2 3

Regioselective alkali metal reduction of dibenzocyclooctadiene lignan derivatives, demethoxylation followed by dehalogenation

The regioselective demethoxylation and dehalogenation of dihalogenated dibenzocyclooctadiene lignans derivatives were realized in a one-step reaction with excellent yields in the sodium and t-butanol reaction system.

Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma

Malignant acanthosis nigricans (MAN), characterized by the presence of a hyperpigmented, velvety cutaneous thickening, is recognized as a cutaneous sign of internal malignancy. Few MAN has been reported in the Asian race ever before. Here, we report a rare case of MAN with severe mucosa and soles and extraordinary facial involvement in the Asian race. A 74-year-old man presented...

Procalcitonin-guided antibiotic therapy in intensive care unit patients: a systematic review and meta-analysis

Background Serum procalcitonin (PCT) concentration is used to guide antibiotic decisions in choice, timing, and duration of anti-infection therapy to avoid antibiotic overuse. Thus, we performed a systematic review and meta-analysis to seek evidence of different PCT-guided antimicrobial strategies for critically ill patients in terms of predefined clinical outcomes. Methods We...

A new scheme for strain typing of methicillin-resistant Staphylococcus aureus on the basis of matrix-assisted laser desorption ionization time-of-flight mass spectrometry by using machine learning approach

and reviewers' efforts and time for improving this work. Author Contributions Data curation: Hsin-Yao Wang, Tsui-Ping Liu, Yung-Ta Chang. Formal analysis: Hsin-Yao Wang, Yi-Ju Tseng, Tsui-Ping Liu ... , Kai-Yao Huang. Investigation: Hsin-Yao Wang, Tzong-Yi Lee, Yi-Ju Tseng, Tsui-Ping Liu, Jang-Jih Lu. Methodology: Hsin-Yao Wang, Tzong-Yi Lee, Kai-Yao Huang, Chun-Hsien Chen, Jang-Jih Lu. Project

Metastatic Breast Carcinoma to the Superior Oblique in a Male

We describe a case of breast cancer metastatic to the superior oblique, in a male. The patient was a 66-year-old Caucasian male with a history of stage IIIB rectal adenocarcinoma and stage IIA left breast carcinoma diagnosed 12 years and 5 years prior, respectively, who presented with headaches and intermittent diplopia. He underwent left total mastectomy with sentinel lymph node...

Targeting cancer stem cells by using chimeric antigen receptor-modified T cells: a potential and curable approach for cancer treatment

; TAA, tumor-associated antigen; WHO, World Health Organization. COMPLIANCE WITH ETHICS GUIDELINES Yelei Guo, Kaichao Feng, Yao Wang, and Weidong Han declare that they have no conflict of interest. This

Pioglitazone ameliorates glomerular NLRP3 inflammasome activation in apolipoprotein E knockout mice with diabetes mellitus

a new underlying mechanism responsible for the beneficial effect of PIO for DN. Author Contributions Conceptualization: Yao Wang, Ming Yang. Data curation: Wei Wei. Formal analysis: Wei Wei ... . Funding acquisition: Xiaochen Yuan. Methodology: Bo Yu, Fengyu Zhang, Xiaochen Yuan. Project administration: Yao Wang, Bo Yu, Li Wang. Resources: Bo Yu, Li Wang. Software: Li Wang. Supervision: Ming

Factor contribution to fire occurrence, size, and burn probability in a subtropical coniferous forest in East China

The contribution of factors including fuel type, fire-weather conditions, topography and human activity to fire regime attributes (e.g. fire occurrence, size distribution and severity) has been intensively discussed. The relative importance of those factors in explaining the burn probability (BP), which is critical in terms of fire risk management, has been insufficiently...

MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients

: Xiaoyu Wen, Jingjing Zhou, Yao Wang. 9 / 11 10 / 11 1. Smyk DS , Rigopoulou EI , Pares A , Billinis C , Burroughs AK , Muratori L , et al. Sex differences associated with primary biliary cirrhosis . Clin

Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers

Wu, Hanren Dai, Qingming Yang, Yao Wang, and Weidong Han declare that they have no conflict of interest. All procedures followed were in accordance with the ethical standards of the responsible

The influence of probe level on the tuning of stimulus frequency otoacoustic emissions and behavioral test in human

Background Frequency selectivity (FS) of the auditory system is established at the level of the cochlea and it is important for the perception of complex sounds. Although direct measurements of cochlear FS require surgical preparation, it can also be estimated with the measurements of otoacoustic emissions or behavioral tests, including stimulus frequency otoacoustic emission...

In vivo whole-cell recording with high success rate in anaesthetized and awake mammalian brains

As a critical technique for dissection of synaptic and cellular mechanisms, whole-cell patch-clamp recording has become feasible for in vivo preparations including both anaesthetized and awake mammalian brains. However, compared with in vitro whole-cell recording, in vivo whole-cell recording often suffers from low success rates and high access resistance, preventing its wide...

Comprehensive N-Glycan Profiling of Cetuximab Biosimilar Candidate by NP-HPLC and MALDI-MS

Monitoring glycosylation of the mAbs have been emphasized and routinely characterized in biopharmaceutical industries because the carbohydrate components are closely related to the safety, efficacy, and consistency of the antibodies. In this study, the comprehensive glycan profiling of a biosimilar candidate of cetuximab was successfully characterized using Normal phase high...

Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy

The genetic modification and characterization of T-cells with chimeric antigen receptors (CARs) allow functionally distinct T-cell subsets to recognize specific tumor cells. The incorporation of costimulatory molecules or cytokines can enable engineered T-cells to eliminate tumor cells. CARs are generated by fusing the antigen-binding region of a monoclonal antibody (mAb) or...

Contour changes in human alveolar bone following tooth extraction of the maxillary central incisor

Bei LI 0 Yao WANG 0 0 (Department of Stomatology, Civil Aviation General Hospital , Beijing 100123 , China) The purpose of this study was to apply cone-beam computed tomography (CBCT) to observe ... (Department of Stomatology, Civil Aviation General Hospital, Beijing, China) for encouragement and assistance for this study. Compliance with ethics guidelines Bei LI and Yao WANG declare that they have no

A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride

A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride Yi Huang,1 Qi Tao,2 Dongzhi Hou,1 Sheng Hu,1 Shuangyan Tian,1 Yanzhong Chen,3 Ruyi Gui,1 Lingling Yang,4 Yao Wang5 1College of Pharmacy, Guangdong Pharmaceutical University, 2Key Laboratory of Mineralogy and Metallogeny, Chinese Academy of Sciences...