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Search: authors:"Yasuhiro Gon"

3 papers found.
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Serum free IgE guided dose reduction of omalizumab: a case report

Omalizumab is a human IgG1 antibody against IgE used as a therapy for sever asthmatic patients with asthma. According to the guidelines of the Global Initiative for Asthma, omalizumab is an add-on drug at treatment step 5 that is used for severe asthma patients who are allergic to perennial allergens. The effects of omalizumab for severe asthma therapy have been validated in ...

Protocadherin-1 is a glucocorticoid-responsive critical regulator of airway epithelial barrier function

Background Impaired epithelial barrier function renders the airway vulnerable to environmental triggers associated with the pathogenesis of bronchial asthma. We investigated the influence of protocadherin-1 (PCDH1), a susceptibility gene for bronchial hyperresponsiveness, on airway epithelial barrier function. Methods We applied transepithelial electric resistance and dextran ...

Role of the FcϵRI β-chain ITAM as a signal regulator for mast cell activation with monomeric IgE

The β-chain of the high-affinity receptor for IgE (FcϵRI) plays a crucial role for amplification of the intracellular signaling in mast cells upon FcϵRI cross-linking by IgE•antigen complexes (IgE•Ag). Some monomeric IgE as well as IgE•Ag stimulate FcϵRI-signaling pathways, leading to cell activation, whereas the biological functions of the β-chain in the monomeric IgE-mediated ...