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Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats

BackgroundSilicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured. Recent advances in stem cell research have made possible the treatment of various diseases including lung fibrosis. The application of stem cell therapy in occupational diseases, in particular the use of adipose-derived mesenchymal stem...

A behavioral change-based approach to energy efficiency in a manufacturing plant

In the realm of industrial energy efficiency studies, very little research has been done to understand the barriers and opportunities to influence behavior of production workers and the corresponding energy-saving potentials. This paper analyzes a case study of Volvo Construction Equipment AB in Braås, Sweden (VCE Braås), that has reduced its relative idle electricity use by more...

Regional Attenuation Correction of Weather Radar Using a Distributed Microwave-Links Network

The complex temporal-spatial variation of raindrop size distribution will affect the precision of precipitation quantitative estimates (QPE) produced from radar data, making it difficult to correct echo attenuation. Given the fact that microwave links can obtain the total path attenuation accurately, we introduce the concept of regional attenuation correction using a multiple...

OCF can repress tumor metastasis by inhibiting epithelial–mesenchymal transition involved in PTEN/PI3K/AKT pathway in lung cancer cells

A component formula with definite compositions provides a new approach to treat various diseases. Salvia miltiorrhiza and Panax ginseng are widely used in China because of their antitumor properties. In the previous study, the optimizing component formula (OCF), prepared with salvianolic acids, ginsenosides, and ginseng polysaccharides (5, 10, and 5 mg·L−1, respectively...

Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing

journals • PubMed • Google Scholar Search for Marc O. Warmoes in:Nature Research journals • PubMed • Google Scholar Search for Ye Yang in:Nature Research journals • PubMed • Google Scholar Contributions

Draft genome sequence of Arthrobacter sp. strain B6 isolated from the high-arsenic sediments in Datong Basin, China

Arthrobacter sp. B6 is a Gram-positive, non-motile, facultative aerobic bacterium, isolated from the arsenic-contaminated aquifer sediment in the Datong basin, China. This strain displays high resistance to arsenic, and can dynamically transform arsenic under aerobic condition. Here, we described the high quality draft genome sequence, annotations and the features of Arthrobacter...

Detection of QTLs for Yield Heterosis in Rice Using a RIL Population and Its Testcross Population

Jie-Yun Zhuang designed the experiments, performed data analysis, and wrote the manuscript. Yu-Jun Zhu, Ye-Yang Fan, and Jie-Yun Zhuang constructed the populations. De-Run Huang, Yu-Jun Zhu, and Zhen ... -Hua Zhang conducted the field experiments. Jie-Zheng Ying and Ye-Yang Fan carried out the marker analysis. All authors read and approved the final manuscript. Acknowledgments This research was funded by

Microbial imbalance and intestinal pathologies: connections and contributions

Microbiome analysis has identified a state of microbial imbalance (dysbiosis) in patients with chronic intestinal inflammation and colorectal cancer. The bacterial phylum Proteobacteria is often overrepresented in these individuals, with Escherichia coli being the most prevalent species. It is clear that a complex interplay between the host, bacteria and bacterial genes is...

Dissection of the qTGW1.1 region into two tightly-linked minor QTLs having stable effects for grain weight in rice

Background Most agronomical traits of crop species are complex traits controlled by multiple genes and affected by environmental factors. While considerable efforts have been made to fine-map and clone major quantitative trait loci (QTLs) for yield-related traits in rice, it is not until recently that the attention has been paid to minor QTLs. Following previous dissection of...

Comparison of Combined and Sequential Surgery for Proliferative Diabetic Retinopathy: A Single Surgeon Study

Purpose To compare the results of combined and consecutive surgeries to treat proliferative diabetic retinopathy and cataract. Methods Retrospective comparative study. Forty-one patients with proliferative diabetic retinopathy (PDR) were enrolled. Twenty-nine eyes for the combined surgery group and twelve eyes for the sequential group were included. All surgeries were performed...

Expression of AE1/p16 promoted degradation of AE2 in gastric cancer cells

Background Human anion exchanger 1 and 2 (AE1 and AE2) mediate the exchange of Cl − /HCO 3 − across the plasma membrane and regulate intracellular pH (pHi). AE1 is specifically expressed on the surface of erythrocytes, while AE2 is widely expressed in most tissues, and is particularly abundant in parietal cells. Previous studies showed that an interaction between AE1 and p16 is a...

Multiple Genetic Modifiers of Bilirubin Metabolism Involvement in Significant Neonatal Hyperbilirubinemia in Patients of Chinese Descent

The potential for genetic variation to modulate neonatal hyperbilirubinemia risk is increasingly being recognized. A case-control study was designed to assess comprehensive contributions of the multiple genetic modifiers of bilirubin metabolism on significant neonatal hyperbilirubinemia in Chinese descendents. Eleven common mutations and polymorphisms across five bilirubin...

Effect of dilution of fuel in CO2 on the conversion of NH3 to NO x during oxy-fuel combustion

The indirect chemical effects of fuel dilution by CO2 on NO formation were investigated numerically in this paper. CH4 doped with NH3 was used as fuel, while CO2 and O2 were mixed as oxidant. The dilution effect of CO2 was then investigated through adding extra CO2 to the reaction system. An isothermal plug flow reactor was used. An unbranched chain reaction mechanism is proposed...

Pharmacokinetics and Bioequivalence Study of Hydroxychloroquine Sulfate Tablets in Chinese Healthy Volunteers by LC–MS/MS

Introduction Hydroxychloroquine (HCQ), 4-aminoquinoline, is an antimalarial drug and has become a basic therapy for rheumatic disease treatment. It can stabilize the condition of SLE patients and reduce the chances of patient relapse through its immunosuppressive function and antiinflammatory effects. This drug was absorbed completely and rapidly by oral administration, but has a...

Lipid metabolism and inflammation modulated by Vitamin D in liver of diabetic rats

Background In recent years, much evidence suggested that vitamin D plays an important role in decreasing the risk of type 2 diabetes. The purpose of this study was to investigate whether 1, 25 (OH) 2D3 can modulate inflammation and lipid metabolism in type 2 diabetic rat liver. Methods Type 2 diabetes was induced in SD rat with high-fat and high-sugar diets and multiple low-dose...

Molecular Design, Structural Analysis and Antifungal Activity of Derivatives of Peptide CGA-N46

Chromogranin A (CGA)-N46, a derived peptide of human chromogranin A, has antifungal activity. To further research the active domain of CGA-N46, a series of derivatives were designed by successively deleting amino acid from both terminus of CGA-N46, and the amino acid sequence of each derivative was analyzed by bioinformatic software. Based on the predicted physicochemical...

Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis

Objective To examine the cross-sectional associations between dietary magnesium (Mg) intake and radiographic knee osteoarthritis (OA), joint space narrowing (JSN), and osteophytes (OST) respectively. Methods A total of 1626 subjects were included in the study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Radiographic knee OA was...

Optimization of the Expression Conditions of CGA-N46 in Bacillus subtilis DB1342(p-3N46) by Response Surface Methodology

CGA-N46 is a small antifungal-derived peptide and consists of the 31st–76th amino acids of the N-terminus of human chromogranin A. Polycistronic expression of recombinant CGA-N46 in Bacillus subtilis DB1342 was used to improve its production, but the yield of CGA-N46 was still low. In the present study, response surface methodology (RSM) was used to optimize culture medium...