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89 papers found.
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Holographic butterfly effect and diffusion in quantum critical region

We investigate the butterfly effect and charge diffusion near the quantum phase transition in holographic approach. We argue that their criticality is controlled by the holographic scaling geometry with deformations induced by a relevant operator at finite temperature. Specifically, in the quantum critical region controlled by a single fixed point, the butterfly velocity...

Data-driven coarse graining of large biomolecular structures

Contributions Methodology: Yi-Ling Chen, Michael Habeck. Software: Michael Habeck. Validation: Yi-Ling Chen, Michael Habeck. Writing ± original draft: Michael Habeck. Writing ± review & editing: Michael

Holographic butterfly effect at quantum critical points

When the Lyapunov exponent λL in a quantum chaotic system saturates the bound λL ≤ 2πk B T , it is proposed that this system has a holographic dual described by a gravity theory. In particular, the butterfly effect as a prominent phenomenon of chaos can ubiquitously exist in a black hole system characterized by a shockwave solution near the horizon. In this paper we propose that...

Holographic shear viscosity in hyperscaling violating theories without translational invariance

In this paper we investigate the ratio of shear viscosity to entropy density, η/s, in hyperscaling violating geometry with lattice structure. We show that the scaling relation with hyperscaling violation gives a strong constraint to the mass of graviton and usually leads to a power law of temperature, η/s ∼ T κ . We find the exponent κ can be greater than two such that the new...

miR-148a-mediated estrogen-induced cholestasis in intrahepatic cholestasis of pregnancy: Role of PXR/MRP3

Intrahepatic cholestasis of pregnancy (ICP) is an idiopathic liver disease while the biochemical characteristic is the elevated level of total bile acid (TBA). The present study investigated whether miR-148a mediates the induced effect of estrogen on the development of ICP and the proper mechanism: PXR/MRP3 signal pathway. mRNA expression was detected by qPCR, protein expression...

Liver resection for hepatocellular carcinoma in patients with hematological malignancies

Improvements in antimetabolite drugs have prolonged the survival of patient with hematological malignancies. However, these drugs may have hepatotoxic side effects and may induce acute liver failure, chronic liver fibrosis, cirrhosis, or even hepatocellular carcinoma (HCC). Although liver resection remains a curative option for HCC, its role in HCC with hematological malignancies...

Comparison of the Mortality in Emergency Department Sepsis Score, Modified Early Warning Score, Rapid Emergency Medicine Score and Rapid Acute Physiology Score for predicting the outcomes of adult splenic abscess patients in the emergency department

assistance in analyzing part of the data. Author Contributions Conceptualization: Joanna Chen-Yeen Seak, Chen-Ken Seak, Chen-June Seak. Data curation: Shang-Kai Hung, Chip-Jin Ng, Chih-Huang Li, Yi-Ling

A novel insulator by holographic Q-lattices

We construct a bulk geometry with Q-lattice structure, which is implemented by two gauge fields and a coupling between the lattice and the Maxwell field. This gravity dual model can describe a novel insulator which exhibits some key features analogous to Mott insulator. In particular, a hard gap in insulating phase as well as vanishing DC conductivity can be simultaneously...

DC and Hall conductivity in holographic massive Einstein-Maxwell-Dilaton gravity

We investigate the holographic DC and Hall conductivity in massive Einstein-Maxwell-Dilaton (EMD) gravity. Two special EMD backgrounds are considered explicitly. One is dyonic Reissner-Nordström-AdS (RN-AdS) geometry and the other one is hyperscaling violation AdS (HV-AdS) geometry. We find that the linear-T resistivity and quadratic-T inverse Hall angle can be simultaneously...

The comprehensive profile of fermentation products during in situ CO 2 recycling by Rubisco-based engineered Escherichia coli

Background In our previous study, the feasibility of Rubisco-based engineered E. coli (that contains heterologous phosphoribulokinase (PrkA) and Rubisco) for in situ CO 2 recycling during the fermentation of pentoses or hexoses was demonstrated. Nevertheless, it is perplexing to see that only roughly 70 % of the carbon fed to the bacterial culture could be accounted for in the...

Global Poincaré inequalities for the composition of the sharp maximal operator and Green’s operator with Orlicz norms

In this paper, we establish the global Poincaré-type inequalities for the composition of the sharp maximal operator and Green’s operator with Orlicz norm.

Regulation of Motility and Phenazine Pigment Production by FliA Is Cyclic-di-GMP Dependent in Pseudomonas aeruginosa PAO1

The transcription factor FliA, also called sigma 28, is a major regulator of bacterial flagellar biosynthesis genes. Growing evidence suggest that in addition to motility, FliA is involved in controlling numerous bacterial behaviors, even though the underlying regulatory mechanism remains unclear. By using a transcriptional fusion to gfp that responds to cyclic (c)-di-GMP, this...

Differential Expression Pattern of THBS1 and THBS2 in Lung Cancer: Clinical Outcome and a Systematic-Analysis of Microarray Databases

Thrombospondin 1 and thrombospondin 2 (THBS1 and THBS2) share similar multifunctional domains, and are known to be antiangiogenic. However, the expression pattern of THBS1 and THBS2 is different, and the specific role of THBS2 in different subtypes of lung cancer remains largely unclear. To evaluate the significance of THBS1 and THBS2 in the development of lung cancer, the...

Holographic entanglement entropy close to quantum phase transitions

We investigate the holographic entanglement entropy (HEE) of a strip geometry in four dimensional Q-lattice backgrounds, which exhibit metal-insulator transitions in the dual field theory. Remarkably, we find that the HEE always displays a peak in the vicinity of the quantum critical points. Our model provides the first direct evidence that the HEE can be used to characterize the...

PNRD: a plant non-coding RNA database

The first ncRNA found was an alanine tRNA in baker's yeast, and the first detected microRNAs (miRNAs) promoted ncRNA research to a whole new level. Research on ncRNAs in animals has focused on the medical field, while in plant scientists are more concerned with improving agronomic traits. In 2010, we constructed a plant miRNA database named PMRD to meet the demand for miRNA...

Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer

Bone density is controlled by interactions between osteoclasts, which resorb bone, and osteoblasts, which deposit it. The semaphorins and their receptors, the plexins, originally shown to function in the immune system and to provide chemotactic cues for axon guidance, are now known to play a role in this process as well. Emerging data have identified Semaphorin 4D (Sema4D) as a...

Effect of Butyrate on Collagen Expression, Cell Viability, Cell Cycle Progression and Related Proteins Expression of MG-63 Osteoblastic Cells

Aims Butyric acid is one major metabolic product generated by anaerobic Gram-negative bacteria of periodontal and root canal infection. Butyric acid affects the activity of periodontal cells such as osteoblasts. The purposes of this study were to investigate the effects of butyrate on MG-63 osteoblasts. Methods MG-63 cells were exposed to butyrate and cell viability was estimated...

Efficient Generation of Plasmacytoid Dendritic Cell from Common Lymphoid Progenitors by Flt3 Ligand

Dendritic cells (DCs), including conventional DCs (cDCs) and plasmacytoid DCs (pDCs) are critical for initiating and controlling the immune response. However, study of DC, particularly pDC, function is hampered by their low frequency in lymphoid organs, and existing methods for in vitro DC generation preferentially favor the production of cDCs over pDCs. Here, we demonstrated...

A Specially Designed Multi-Gene Panel Facilitates Genetic Diagnosis in Children with Intrahepatic Cholestasis: Simultaneous Test of Known Large Insertions/Deletions

Background and Aims Large indels are commonly identified in patients but are not detectable by routine Sanger sequencing and panel sequencing. We specially designed a multi-gene panel that could simultaneously test known large indels in addition to ordinary variants, and reported the diagnostic yield in patients with intrahepatic cholestasis. Methods The panel contains 61 genes...