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84 papers found.
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Holographic butterfly effect and diffusion in quantum critical region

We investigate the butterfly effect and charge diffusion near the quantum phase transition in holographic approach. We argue that their criticality is controlled by the holographic scaling geometry with deformations induced by a relevant operator at finite temperature. Specifically, in the quantum critical region controlled by a single fixed point, the butterfly velocity decreases ...

Data-driven coarse graining of large biomolecular structures

Contributions Methodology: Yi-Ling Chen, Michael Habeck. Software: Michael Habeck. Validation: Yi-Ling Chen, Michael Habeck. Writing ± original draft: Michael Habeck. Writing ± review & editing: Michael

miR-148a-mediated estrogen-induced cholestasis in intrahepatic cholestasis of pregnancy: Role of PXR/MRP3

Intrahepatic cholestasis of pregnancy (ICP) is an idiopathic liver disease while the biochemical characteristic is the elevated level of total bile acid (TBA). The present study investigated whether miR-148a mediates the induced effect of estrogen on the development of ICP and the proper mechanism: PXR/MRP3 signal pathway. mRNA expression was detected by qPCR, protein expression ...

Holographic shear viscosity in hyperscaling violating theories without translational invariance

In this paper we investigate the ratio of shear viscosity to entropy density, η/s, in hyperscaling violating geometry with lattice structure. We show that the scaling relation with hyperscaling violation gives a strong constraint to the mass of graviton and usually leads to a power law of temperature, η/s ∼ T κ . We find the exponent κ can be greater than two such that the new ...

A novel insulator by holographic Q-lattices

We construct a bulk geometry with Q-lattice structure, which is implemented by two gauge fields and a coupling between the lattice and the Maxwell field. This gravity dual model can describe a novel insulator which exhibits some key features analogous to Mott insulator. In particular, a hard gap in insulating phase as well as vanishing DC conductivity can be simultaneously ...

The comprehensive profile of fermentation products during in situ CO 2 recycling by Rubisco-based engineered Escherichia coli

Background In our previous study, the feasibility of Rubisco-based engineered E. coli (that contains heterologous phosphoribulokinase (PrkA) and Rubisco) for in situ CO 2 recycling during the fermentation of pentoses or hexoses was demonstrated. Nevertheless, it is perplexing to see that only roughly 70 % of the carbon fed to the bacterial culture could be accounted for in the ...

DC and Hall conductivity in holographic massive Einstein-Maxwell-Dilaton gravity

We investigate the holographic DC and Hall conductivity in massive Einstein-Maxwell-Dilaton (EMD) gravity. Two special EMD backgrounds are considered explicitly. One is dyonic Reissner-Nordström-AdS (RN-AdS) geometry and the other one is hyperscaling violation AdS (HV-AdS) geometry. We find that the linear-T resistivity and quadratic-T inverse Hall angle can be simultaneously ...

Differential Expression Pattern of THBS1 and THBS2 in Lung Cancer: Clinical Outcome and a Systematic-Analysis of Microarray Databases

Thrombospondin 1 and thrombospondin 2 (THBS1 and THBS2) share similar multifunctional domains, and are known to be antiangiogenic. However, the expression pattern of THBS1 and THBS2 is different, and the specific role of THBS2 in different subtypes of lung cancer remains largely unclear. To evaluate the significance of THBS1 and THBS2 in the development of lung cancer, the present ...

Regulation of Motility and Phenazine Pigment Production by FliA Is Cyclic-di-GMP Dependent in Pseudomonas aeruginosa PAO1

The transcription factor FliA, also called sigma 28, is a major regulator of bacterial flagellar biosynthesis genes. Growing evidence suggest that in addition to motility, FliA is involved in controlling numerous bacterial behaviors, even though the underlying regulatory mechanism remains unclear. By using a transcriptional fusion to gfp that responds to cyclic (c)-di-GMP, this ...

Holographic entanglement entropy close to quantum phase transitions

We investigate the holographic entanglement entropy (HEE) of a strip geometry in four dimensional Q-lattice backgrounds, which exhibit metal-insulator transitions in the dual field theory. Remarkably, we find that the HEE always displays a peak in the vicinity of the quantum critical points. Our model provides the first direct evidence that the HEE can be used to characterize the ...

Effect of Butyrate on Collagen Expression, Cell Viability, Cell Cycle Progression and Related Proteins Expression of MG-63 Osteoblastic Cells

Aims Butyric acid is one major metabolic product generated by anaerobic Gram-negative bacteria of periodontal and root canal infection. Butyric acid affects the activity of periodontal cells such as osteoblasts. The purposes of this study were to investigate the effects of butyrate on MG-63 osteoblasts. Methods MG-63 cells were exposed to butyrate and cell viability was estimated ...

Global Poincaré inequalities for the composition of the sharp maximal operator and Green’s operator with Orlicz norms

In this paper, we establish the global Poincaré-type inequalities for the composition of the sharp maximal operator and Green’s operator with Orlicz norm.

A Specially Designed Multi-Gene Panel Facilitates Genetic Diagnosis in Children with Intrahepatic Cholestasis: Simultaneous Test of Known Large Insertions/Deletions

Background and Aims Large indels are commonly identified in patients but are not detectable by routine Sanger sequencing and panel sequencing. We specially designed a multi-gene panel that could simultaneously test known large indels in addition to ordinary variants, and reported the diagnostic yield in patients with intrahepatic cholestasis. Methods The panel contains 61 genes ...

Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer

Bone density is controlled by interactions between osteoclasts, which resorb bone, and osteoblasts, which deposit it. The semaphorins and their receptors, the plexins, originally shown to function in the immune system and to provide chemotactic cues for axon guidance, are now known to play a role in this process as well. Emerging data have identified Semaphorin 4D (Sema4D) as a ...

Switch Function and Pathological Dissociation in Acute Psychiatric Inpatients

Swift switching, along with atypical ability on updating and inhibition, has been found in non-clinical dissociators. However, whether swift switching is a cognitive endophenotype that intertwines with traumatisation and pathological dissociation remains unknown. Unspecified acute psychiatric patients were recruited to verify a hypothesis that pathological dissociation is ...

PNRD: a plant non-coding RNA database

The first ncRNA found was an alanine tRNA in baker's yeast, and the first detected microRNAs (miRNAs) promoted ncRNA research to a whole new level. Research on ncRNAs in animals has focused on the medical field, while in plant scientists are more concerned with improving agronomic traits. In 2010, we constructed a plant miRNA database named PMRD to meet the demand for miRNA ...

Efficient Generation of Plasmacytoid Dendritic Cell from Common Lymphoid Progenitors by Flt3 Ligand

Dendritic cells (DCs), including conventional DCs (cDCs) and plasmacytoid DCs (pDCs) are critical for initiating and controlling the immune response. However, study of DC, particularly pDC, function is hampered by their low frequency in lymphoid organs, and existing methods for in vitro DC generation preferentially favor the production of cDCs over pDCs. Here, we demonstrated that ...

Reduced deformability of parasitized red blood cells as a biomarker for anti-malarial drug efficacy

Background Malaria remains a challenging and fatal infectious disease in developing nations and the urgency for the development of new drugs is even greater due to the rapid spread of anti-malarial drug resistance. While numerous parasite genetic, protein and metabolite biomarkers have been proposed for testing emerging anti-malarial compounds, they do not universally correspond ...

Japanese Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial Trifunctional Protein and Impairs Fatty Acid β-Oxidation

Infection with Japanese encephalitis virus (JEV) can induce the expression of pro-inflammatory cytokines and cause acute encephalitis in humans. β-oxidation breaks down fatty acids for ATP production in mitochondria, and impaired β-oxidation can induce pro-inflammatory cytokine expression. To address the role of fatty-acid β-oxidation in JEV infection, we measured the oxygen ...

Japanese encephalitis virus replicon-based vaccine expressing enterovirus-71 epitope confers dual protection from lethal challenges

Background To construct safer recombinant flavivirus vaccine, we exploited Japanese encephalitis virus (JEV) replicon-based platform to generate single-round infectious particles (SRIPs) that expressed heterologous neutralizing epitope SP70 derived from enterovirus-71 (EV71). Such pseudo-infectious virus particles, named SRIP-SP70, although are not genuine viable viruses, closely ...