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134 papers found.
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Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonly associated with impairments in neuronal function and cognition, but its relationship and role in...

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonly associated with impairments in neuronal function and cognition, but its relationship and role in...

Interference alignment and power allocation for the MIMO X channels with multiple layers of relays

In this paper, we study a system consisting of a single source, a single destination, and multiple layers of parallel relays. The system is considered as a combination of broadcast channels, multiple input multiple output (MIMO) X channels, and multiple-access channels. Interference alignment (IA) is used throughout the whole system, and perfect channel state information (CSI) is...

Metformin: a review of its potential indications

Metformin: a review of its potential indications Yi-Wei Wang,1,* Si-Jia He,1,* Xiao Feng,1 Jin Cheng,1 Yun-Tao Luo,1 Ling Tian,2 Qian Huang1 1The Comprehensive Cancer Center and Shanghai Key

Single-component and fast-curing epoxy resin for liquid composite molding processes

Development of single-component and fast-curing epoxy resins is highly desired for many industry applications. In this work, we report an epoxy system based on diglycidyl ether of bisphenol A (DGEBA) and 1-(2-cyanoethyl)-2-ethyl-4- methylimidazole (1C2E4MIM). The inductive effect of electron-withdrawing cyano group distinctly increases the latency of 1C2E4MIM without sacrificing...

The herbal decoction modified Danggui Buxue Tang attenuates immune-mediated bone marrow failure by regulating the differentiation of T lymphocytes in an immune-induced aplastic anemia mouse model

Conceptualization: Limin Chai. Data curation: Peiying Deng, Xue Li, Yi Wei. Formal analysis: Peiying Deng, Xue Li, Yi Wei, Juan Liu, Meng Chen. Funding acquisition: Limin Chai. Investigation: Lingqun Zhu, Limin

Cell sex affects extracellular matrix protein expression and proliferation of smooth muscle progenitor cells derived from human pluripotent stem cells

Background Smooth muscle progenitor cells (pSMCs) differentiated from human pluripotent stem cells (hPSCs) hold great promise for treating diseases or degenerative conditions involving smooth muscle pathologies. However, the therapeutic potential of pSMCs derived from men and women may be very different. Cell sex can exert a profound impact on the differentiation process of stem...

In-depth study of DNA binding of Cys2His2 finger domains in testis zinc-finger protein

Previously, we identified that both fingers 1 and 2 in the three Cys2His2 zinc-finger domains (TZD) of testis zinc-finger protein specifically bind to its cognate DNA; however, finger 3 is non-sequence–specific. To gain insights into the interaction mechanism, here we further investigated the DNA-binding characteristics of TZD bound to non-specific DNAs and its finger segments...

A Novel Inhibitor Against Mushroom Tyrosinase with a Double Action Mode and Its Application in Controlling the Browning of Potato

In order to search for a new method for the anti-browning of food products, a novel hydroxypyridinone (HPO) derivative with a formyl group was evaluated for its anti-tyrosinase property. This compound was found to exhibit potent tyrosinase inhibition on the monophenolase activity of mushroom tyrosinase with an IC50 value of 1.33 μM, indicating that this HPO derivative was 12-fold...

Laboratory Diagnosis of Central Nervous System Infection

Central nervous system (CNS) infections are potentially life threatening if not diagnosed and treated early. The initial clinical presentations of many CNS infections are non-specific, making a definitive etiologic diagnosis challenging. Nucleic acid in vitro amplification-based molecular methods are increasingly being applied for routine microbial detection. These methods are a...

Replacing process water and nitrogen sources with biogas slurry during cellulosic ethanol production

Environmental issues, such as the fossil energy crisis, have resulted in increased public attention to use bioethanol as an alternative renewable energy. For ethanol production, water and nutrient consumption has become increasingly important factors being considered by the bioethanol industry as reducing the consumption of these resources would decrease the overall cost of...

Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy

Diffuse intrinsic pontine glioma is a very frustrating disease. Since the tumor infiltrates the brain stem, surgical removal is often impossible. For conventional radiotherapy, the dose constraint of the brain stem impedes attempts at further dose escalation. Boron neutron capture therapy (BNCT), a targeted radiotherapy, carries the potential to selectively irradiate tumors with...

An Early Instance of Upper Palaeolithic Personal Ornamentation from China: The Freshwater Shell Bead from Shuidonggou 2

We report the discovery and present a detailed analysis of a freshwater bivalve from Shuidonggou Locality 2, layer CL3. This layer is located c. 40 cm below layer CL2, which has yielded numerous ostrich eggshell beads. The shell is identified as the valve of a Corbicula fluminea. Data on the occurrence of this species in the Shuidonggou region during Marine Isotope Stage 3 and...

Nasal nitric oxide in unilateral sinus disease

Unilateral sinus disease (USD) can sometimes be difficult to accurately diagnose before surgery. The application of nasal nitric oxide (nNO) for USD diagnosis and its surgical outcome in USD has not been reported in the literature. We prospectively enrolled sixty-six USD patients who underwent endoscopic sinus surgery for fungal rhinosinusitis (n = 19), chronic rhinosinusitis...

Synergistic activation of Arg1 gene by retinoic acid and IL-4 involves chromatin remodeling for transcription initiation and elongation coupling

-Wei Lin 0 Sung Wook Park 0 Li-Na Wei 0 0 Department of Pharmacology, Medical School, University of Minnesota , Minneapolis, MN 55455 , USA All-trans Retinoic acid (RA) and its derivatives are potent

Inactivation of SmeSyRy Two-Component Regulatory System Inversely Regulates the Expression of SmeYZ and SmeDEF Efflux Pumps in Stenotrophomonas maltophilia

SmeYZ efflux pump is a critical pump responsible for aminoglycosides resistance, virulence-related characteristics (oxidative stress susceptibility, motility, and secreted protease activity), and virulence in Stenotrophomonas maltophilia. However, the regulatory circuit involved in SmeYZ expression is little known. A two-component regulatory system (TCS), smeRySy, transcribed...

Three-dimensional imaging of the nucleon and semi-inclusive high-energy reactions

We present a short overview of studies of the transverse-momentum-dependent parton distribution functions of the nucleon. The aim of such studies is to provide three-dimensional imaging of the nucleon and a comprehensive description of semi-inclusive high-energy reactions. By summarizing what we have done in constructing the theoretical framework for inclusive deep inelastic...

The SLC6A3 gene possibly affects susceptibility to late-onset alcohol dependence but not specific personality traits in a Han Chinese population

Dopaminergic dysfunction has an important role in the pathoetiology of alcohol dependence (AD). The purpose of this study was to determine whether the solute carrier family 6 member 3 (SLC6A3) gene (also known as the dopamine transporter DAT gene) was associated with AD, and whether variants in the SLC6A3 locus were associated with specific personality traits in patients with AD...