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A chance-constrained stochastic approach to intermodal container routing problems

Zhao. Formal analysis: Yi Zhao. Funding acquisition: Xi Zhang. Investigation: Yi Zhao. Methodology: Yi Zhao, Ronghui Liu. Supervision: Ronghui Liu. Writing ± original draft: Yi Zhao. Writing ... information S1 Appendix. Parameter setting for the numerical example. (DOCX) Acknowledgments We thank Hongbo Ye (University of Leeds) for his technical support. Author Contributions Conceptualization: Yi

Pirh2 mediates the sensitivity of myeloma cells to bortezomib via canonical NF-κB signaling pathway

, Yi Zhao, Yang Yang, Jingsong He, and Zhen Cai declare that they have no conflict of interest. All procedures followed were in accordance with the ethical standards of the responsible committee on human

Identification of race-associated metabolite biomarkers for hepatocellular carcinoma in patients with liver cirrhosis and hepatitis C virus infection

. Varghese, Yi Zhao, Alessia Ferrarini. Formal analysis: Cristina Di Poto, Shisi He, Yi Zhao, Mahlet G. Tadesse. Methodology: Cristina Di Poto, Alessia Ferrarini. Project administration: Cristina Di Poto

Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation

There is currently no FDA approved therapeutic agent for ARS mitigation post radiation exposure. Here we report that the small molecule YH250, which specifically antagonizes p300/catenin interaction, stimulates hematopoiesis in lethally or sublethally irradiated mice. A single administration of YH250 24 hours post irradiation can significantly stimulate HSC proliferation, improve...

Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population

donating blood samples. Author Contributions Conceptualization: Yi Zhao, Yuhong Zhang. Data curation: Yi Zhao. Formal analysis: Xiaoxia Li. Funding acquisition: Yuhong Zhang. Investigation: Xiaoxia Li ... , Yi Zhao, Yanan Jin, Tianjing Zhang, Xiaoyu Chang, Sha Liao, Hongxia Xu, Xiuying Liu, Jianjun Yang. 9 / 12 Project administration: Yuhong Zhang. Supervision: Yuhong Zhang. Writing ± original draft

Efficacy differences of electroacupuncture with single acupoint or matching acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial

Previous studies have shown that acupuncture is beneficial for the alleviation of chemotherapy-induced nausea and vomiting. However, there is a lack of clinical evidence concerning the effects of acupoint-matching on chemotherapy-induced nausea and vomiting. This is a parallel randomized controlled trial to evaluate the occurrence of nausea and vomiting after chemotherapy (the...

dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers

MicroRNAs (miRNAs) are often deregulated in cancer and are thought to play an important role in cancer development. Large amount of differentially expressed miRNAs have been identified in various cancers by using high-throughput methods. It is therefore quite important to make a comprehensive collection of these miRNAs and to decipher their roles in oncogenesis and tumor...

Mapping and differential expression analysis from short-read RNA-Seq data in model organisms

China (No. 31571310). COMPLIANCE WITH ETHICS GUIDELINES The authors Qiong-Yi Zhao, Jacob Gratten, Restuadi Restuadi and Xuan Li declare that they have no conflict of interest. This article does not

Prevention of stack corrosion under wet flue gas desulfurization conditions in a coal-fired power plant: performance analysis and comparative study

Background This study investigated the prevention of stack corrosion under wet flue gas desulfurization conditions in a coal-fired power plant. The performance analysis and comparative studies of six materials for the prevention of stack corrosion were investigated. Results The ion chromatography analysis showed the acid condensation contained fluoride, chloride, nitrate...

The carboxypeptidase D homolog silver regulates memory formation via insulin pathway in Drosophila

. Z.), the Tsinghua-Peking Joint Center for Life Sciences and the Tsinghua University Initiative Scientific Research Program (20111080956, to Y. Z.). Binyan Lu, Yi Zhao, Jie Zhao, Xiaoyang Yao, Yichun

De novo assembly of transcriptome from next-generation sequencing data

(Nos. 31571310 and 31271409). COMPLIANCE WITH ETHICS GUIDELINES The authors Xuan Li, Yimeng Kong, Qiong-Yi Zhao, Yuan-Yuan Li and Pei Hao declare they have no conflict of interests. This article does

FUS-linked essential tremor associated with motor dysfunction in Drosophila

Essential tremor (ET) is one of the most common adult-onset neurological disorders which produce motor and non-motor symptoms. To date, there are no gold standard pathological hallmarks of ET, and despite a strong genetic contribution toward ET development, only a few pathogenic mutations have been identified. Recently, a pathogenic FUS-Q290X mutation has been reported in a large...

NPInter v3.0: an upgraded database of noncoding RNA-associated interactions

Despite the fact that a large quantity of noncoding RNAs (ncRNAs) have been identified, their functions remain unclear. To enable researchers to have a better understanding of ncRNAs’ functions, we updated the NPInter database to version 3.0, which contains experimentally verified interactions between ncRNAs (excluding tRNAs and rRNAs), especially long noncoding RNAs (lncRNAs...

Comprehensive Transcriptome Analyses of the Fructose-Fed Syrian Golden Hamster Liver Provides Novel Insights into Lipid Metabolism

Dyslipidemia has been widely proven to contribute to cardiovascular diseases and other metabolic disorders, especially in insulin resistance and type 2 diabetes. The overproduction of VLDL is a significant characteristic of dyslipidemia, indicating the dysfunction of hepatic lipid metabolism, from triglyceride synthesis to transport. The fructose-fed Syrian golden hamster is an...

10-Year experience regarding the reliability and morbidity of radio guided lymph node biopsy in penile cancer patients and the associated radiation exposure of medical staff in this procedure

Background The guidelines of the European Association of Urologists (EAU), of the German Society of Nuclear Medicine (DGN), and the European Society for Medical Oncology (ESMO) recommend sentinel lymph node biopsy (SLNB) for lymph node staging in penile cancer with non-palpable inguinal lymph nodes as one diagnostic method. Despite this, the method is neither widely nor regularly...

Impact of miRNA Sequence on miRNA Expression and Correlation between miRNA Expression and Cell Cycle Regulation in Breast Cancer Cells

The miRNAs regulate cell functions by inhibiting expression of proteins. Research on miRNAs had usually focused on identifying targets by base pairing between miRNAs and their targets. Instead of identifying targets, this paper proposed an innovative approach, namely impact significance analysis, to study the correlation between mature sequence, expression across patient samples...

Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model

Background Epigenetic regulation has emerged to be the critical steps for tumorigenesis and metastasis. Multiple histone methyltransferase and demethylase have been implicated as tumor suppressors or oncogenes recently. But the key epigenomic events in cancer cell transformation still remain poorly understood. Methods A breast cancer transformation model was established via...

Modeling miRNA-mRNA interactions: fitting chemical kinetics equations to microarray data

Background The miRNAs are small non-coding RNAs of roughly 22 nucleotides in length, which can bind with and inhibit protein coding mRNAs through complementary base pairing. By degrading mRNAs and repressing proteins, miRNAs regulate the cell signaling and cell functions. This paper focuses on innovative mathematical techniques to model gene interactions by algorithmic analysis...

Hemoporfin Photodynamic Therapy for Port-Wine Stain: A Randomized Controlled Trial

Background and Objectives Photodynamic therapy (PDT) has shown potentially beneficial results in treating port-wine stain, but its benefit–risk profile remains undefined. This study aimed to evaluate the efficacy and safety of PDT conducted with hemoporfin and a 532 nm continuous wave laser to treat port-wine stain clinically. Patients and Methods This randomized clinical trial...

Identification of miRNAs during mouse postnatal ovarian development and superovulation

Background MicroRNAs are small noncoding RNAs that play critical roles in regulation of gene expression in wide array of tissues including the ovary through sequence complementarity at post-transcriptional level. Tight regulation of multitude of genes involved in ovarian development and folliculogenesis could be regulated at transcription level by these miRNAs. Therefore, tissue...