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56 papers found.
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Food claims and nutrition facts of commercial infant foods

. Author Contributions Conceptualization: Yi Chun Chen. Data curation: Yu-Chin Koo. Formal analysis: Yu-Chin Koo, Jung-Su Chang. Funding acquisition: Yu-Chin Koo, Yi Chun Chen. Investigation: Yi Chun Chen ... . Methodology: Yu-Chin Koo, Yi Chun Chen. Project administration: Yi Chun Chen. Resources: Yu-Chin Koo, Yi Chun Chen. Software: Yu-Chin Koo, Yi Chun Chen. 11 / 13 Supervision: Yi Chun Chen. Validation: Yu

Detection of mitochondrial DNA with 4977 bp deletion in leukocytes of patients with ischemic stroke

/ 11 Author Contributions Conceptualization: Yu-hua Huang, Yi-Chun Chen. Data curation: Chiung-Mei Chen, Kuo-Hsuan Chang, Huei-Wen Chen. Formal analysis: Yu-hua Huang, Huei-Wen Chen. Methodology ... : Chiung-Mei Chen, Yun-Shien Lee, Kuo-Hsuan Chang. Project administration: Yi-Chun Chen. Supervision: Yi-Chun Chen. Writing ± original draft: Yu-hua Huang. Writing ± review & editing: Yi-Chun Chen. 9

Comparison of the new Exponential Injury Severity Score with the Injury Severity Score and the New Injury Severity Score in trauma patients: A cross-sectional study

Conceptualization: Ching-Hua Hsieh. Formal analysis: Yi-Chun Chen. Project administration: Pao-Jen Kuo. Supervision: Ching-Hua Hsieh. Validation: Peng-Chen Chien. Writing ± original draft: Spencer C. H. Kuo

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Rhodostomin (Rho) is a medium disintegrin containing a 48PRGDMP motif. We here showed that Rho proteins with P48A, M52W, and P53N mutations can selectively inhibit integrin αIIbβ3. To study the roles of the RGD loop and C-terminal region in disintegrins, we expressed Rho 48PRGDMP and 48ARGDWN mutants in Pichia pastoris containing 65P, 65PR, 65PRYH, 65PRNGLYG, and 65PRNPWNG C...

Risk of Flood-Related Diseases of Eyes, Skin and Gastrointestinal Tract in Taiwan: A Retrospective Cohort Study

Floods are known to cause serious environmental damage and health impacts. Studies on flood-related diseases have been primarily on individual events, and limited evidence could be drawn on potential health impacts from floods using large population data. This study used reimbursement records of one million people of the Taiwan National Health Insurance program to compare...

Post-traumatic acute kidney injury: a cross-sectional study of trauma patients

Background The causes of post-traumatic acute kidney injury (AKI) are multifactorial, and shock associated with major trauma has been proposed to result in inadequate renal perfusion and subsequent AKI in trauma patients. This study aimed to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized adult patients and its association with shock...

Polymorphisms in the Promoters of the MMP-2 and TIMP-2 Genes Are Associated with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population

Background Spontaneous intracerebral hemorrhage (ICH) is a devastating stroke subtype. Matrix metalloproteinases (MMPs) function in the degradation of extracellular matrix and the activities of MMPs are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). This study aimed to discuss relationship of MMP-2 and TIMP-2 to spontaneous deep ICH...

13-year nationwide cohort study of chronic kidney disease risk among treatment-naïve patients with chronic hepatitis B in Taiwan

Background Chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD) have high prevalences in Taiwan and worldwide. However, the association of untreated chronic hepatitis B virus (HBV) infection with chronic kidney disease (CKD) remains unclear. Methods This cohort study used claims data in the Taiwan National Health Insurance Research Database in 1996–2010, in...

Development of a Simple Clinical Risk Score for Early Prediction of Severe Dengue in Adult Patients

We aimed to develop and validate a risk score to aid in the early identification of laboratory-confirmed dengue patients at high risk of severe dengue (SD) (i.e. severe plasma leakage with shock or respiratory distress, or severe bleeding or organ impairment). We retrospectively analyzed data of 1184 non-SD patients at hospital presentation and 69 SD patients before SD onset. We...

Obese motorcycle riders have a different injury pattern and longer hospital length of stay than the normal-weight patients

Background The adverse effects of obesity on the physical health have been extensively studied in the general population, but not in motorcycle riders (includes both drivers and pillions). The aim of this study was to compare injury patterns, injury severities, mortality rates, and in-hospital or intensive care unit (ICU) length of stay (LOS) between obese and normal-weight...

Traumatic injuries among adult obese patients in southern Taiwan: a cross-sectional study based on a trauma registry system

Background The adverse impact of obesity has been extensively studied in the general population; however, the added risk of obesity on trauma-related mortality remains controversial. This study investigated and compared mortality as well injury patterns and length of stay (LOS) in obese and normal-weight patients hospitalized for trauma in the hospital and intensive care unit...

Use of the reverse shock index for identifying high-risk patients in a five-level triage system

Background The ratio of systolic blood pressure (SBP) to heart rate (HR), called the reverse shock index (RSI), is used to evaluate the hemodynamic stability of trauma patients. To minimize undertriage in emergency departments (EDs), we evaluated whether RSI < 1 (i.e., SBP lower than HR) could be used as an additional variable to identify patients at high risk for more severe...

Obese patients who fall have less injury severity but a longer hospital stay than normal-weight patients

Background The effects of obesity on injury severity and outcome have been studied in trauma patients but not in those who have experienced a fall. The aim of this study was to compare injury patterns, injury severities, mortality rates, and in-hospital or intensive care unit (ICU) length of stay (LOS) between obese and normal-weight patients following a fall. Methods Detailed...

Mig6 haploinsufficiency protects mice against streptozotocin-induced diabetes

Yi-Chun Chen E. Scott Colvin Katherine E. Griffin Bernhard F. Maier Patrick T. Fueger 0 ) Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine , 635 Barnhill Drive

Increasing trend of fluconazole-non-susceptible Cryptococcus neoformans in patients with invasive cryptococcosis: a 12-year longitudinal study

Background This study aimed to investigate the rate of fluconazole-non-susceptible Cryptococcus neoformans in Southern Taiwan for the period 2001–2012 and analyze the risk factors for acquiring it among patients with invasive cryptococcosis. Methods All enrolled strains were isolated from blood or cerebrospinal fluid samples of the included patients. If a patient had multiple...

Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population

Background Spontaneous deep intracerebral hemorrhage (SDICH) is a devastating stroke subtype. The causes of SDICH are heterogeneous. Matrix metalloproteinase-9 (MMP-9, Gelantinase B) has been shown to relate to stroke and the development of aneurysm and may increase risks of intracerebral hemorrhage. MMP activities are modulated by their endogenous inhibitors, tissue inhibitors...

Profiling the circulating miRNAs in mice exposed to gram-positive and gram-negative bacteria by Illumina small RNA deep sequencing

Background We profiled the expression of circulating microRNAs (miRNAs) in mice using Illumina small RNA deep sequencing in order to identify the miRNAs that may potentially be used as biomarkers to distinguish between gram-negative and gram-positive bacterial infections. Results Recombinant-specific gram-negative pathogen Escherichia coli (Xen14) and gram-positive pathogen...

Hepatitis C virus itself is a causal risk factor for chronic kidney disease beyond traditional risk factors: a 6-year nationwide cohort study across Taiwan

Background Hepatitis C virus (HCV) infection and chronic kidney disease (CKD) have high prevalences in Taiwan and worldwide, but the role of HCV infection in causing CKD remains uncertain. This cohort study aimed to explore this association. Methods This nationwide cohort study examined the association of HCV with CKD by analysis of sampled claims data from Taiwan National Health...

All-Cause Mortality in Patients with Type 2 Diabetes in Association with Achieved Hemoglobin A1c, Systolic Blood Pressure, and Low-Density Lipoprotein Cholesterol Levels

Background To identify the ranges of hemoglobin A1c (HbA1c), systolic blood pressure (SBP), and low-density lipoprotein cholesterol (LDL-C) levels which are associated with the lowest all-cause mortality. Methods A retrospective cohort of 12,643 type 2 diabetic patients (aged ≥18 years) were generated from 2002 to 2010, in Far-Eastern Memorial Hospital, New Taipei city, Taiwan...