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9 papers found.
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Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice

: Che-Chung Yeh, Yanying Fan, Yanchun Xu, Yi-Lin Yang. Formal analysis: Che-Chung Yeh, Yanying Fan, Paul C. Simpson, Michael J. Mann. Funding acquisition: Michael J. Mann. Investigation: Yanying Fan ... , Yanchun Xu, Yi-Lin Yang. Methodology: Che-Chung Yeh, Yanying Fan, Paul C. Simpson, Michael J. Mann. Project administration: Michael J. Mann. Resources: Michael J. Mann. Supervision: Michael J. Mann

Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for normal cardiac development. We investigated the effect of active MEK1 overexpression on fetal atrial septal development. An inducible double transgenic (DTg) mouse model was ...

Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2

Background Casein kinase 2 (CK2) is involved in various cellular events such as proliferation, apoptosis, and the cell cycle. CK2 overexpression is associated with multiple human cancers and may therefore be a promising target for cancer therapy. To identity novel classes of inhibitors for CK2, we screened a natural product library obtained from National Cancer Institute. Methods ...

CK2?, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells

Background The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signaling pathways through the mechanism of phosphorylation. Methods Protein and mRNA levels of CK2? and Gli1 were tested by quantitative RT-PCR and immunohistochemistry ...

Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer

Background Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signaling through Frizzled-8 in non-small cell lung cancer, and (2) test whether a novel expression construct dominant negative Wnt-2 (dnhWnt-2) reduces tumor growth in ...

Evaluation of carotid artery elasticity changes in patients with type 2 diabetes

Background Type 2 diabetes is one of the most common causes of cardiovascular disease as it causes arterial stiffness changes. The purpose of this study is to characterize, in vivo, carotid arterial structural and functional changes by applying radio frequency and X-strain ultrasound techniques. Methods Ninety-one subjects were assigned into two groups; a diabetes group and a ...

A prospective experimental study of liver fibrosis with ultrasound and its correlation with hepatic reserve function and hemodynamics

Background Progressive hepatic fibrosis is the eventual cause of liver cirrhosis. Doppler ultrasound has been used to detect hemodynamic changes that are known to be present during the pre-cirrhotic stages of hepatic fibrogenesis. However, the relationship between the Doppler ultrasound parameters and the impairment of the liver function has not been fully investigated. The purpose ...

Artificial neural network aided non-invasive grading evaluation of hepatic fibrosis by duplex ultrasonography

-zhen Yan Yi-lin Yang Rui-jing Yang 0 Equal contributors Department of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical University , Xi'an , China Background: Artificial neural networks

Comparison of tricuspid inflow and superior vena caval Doppler velocities in acute simulated hypovolemia: new non-invasive indices for evaluating right ventricular preload

Background Assessment of cardiac preload is important for clinical management of some emergencies related to hypovolemia. Effects of acute simulated hypovolemia on Doppler blood flow velocity indices of tricuspid valve (TV) and superior vena cava (SVC) were investigated in order to find sensitive Doppler indices for predicting right ventricular preload. Methods Doppler flow ...