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26 papers found.
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Comments on the twisted punctures of Aeven class S theory

Abstract We point out that the USp symmetry associated to a full twisted puncture of a class S theory of type Aeven has the global anomaly associated to π4(USp) = ℤ2. We discuss manifestations of this fact in the context of the superconformal field theory R2,2N introduced by Chacaltana, Distler and Trimm. For example, we find that this theory can be thought of as a natural...

Doxorubicin and anti-VEGF siRNA co-delivery via nano-graphene oxide for enhanced cancer therapy in vitro and in vivo

Doxorubicin and anti-VEGF siRNA co-delivery via nano-graphene oxide for enhanced cancer therapy in vitro and in vivo Qi Sun,1–3 Xiaoli Wang,1–3 Chunying Cui,1–3 Jing Li,1–3 Yifan Wang1–3 1Department of Pharmaceutics, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China; 2Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Beijing, China...

Romans supergravity from five-dimensional holograms

Abstract We study five-dimensional superconformal field theories and their holographic dual, matter-coupled Romans supergravity. On the one hand, some recently derived formulae allow us to extract the central charges from deformations of the supersymmetric five-sphere partition function, whose large N expansion can be computed using matrix model techniques. On the other hand, the...

Doxorubicin-loaded redox-responsive micelles based on dextran and indomethacin for resistant breast cancer

Doxorubicin-loaded redox-responsive micelles based on dextran and indomethacin for resistant breast cancer Yunfang Zhou,1,* Shuanghu Wang,1,* Xuhua Ying,2 Yifan Wang,2 Peiwu Geng,1 Aiping Deng,3

\( \mathcal{N} \) = 4 superconformal bootstrap of the K3 CFT

We study two-dimensional (4, 4) superconformal field theories of central charge c = 6, corresponding to nonlinear sigma models on K3 surfaces, using the superconformal bootstrap. This is made possible through a surprising relation between the BPS \( \mathcal{N} \) = 4 superconformal blocks with c = 6 and bosonic Virasoro conformal blocks with c = 28, and an exact result on the...

(2, 2) superconformal bootstrap in two dimensions

We find a simple relation between two-dimensional BPS \( \mathcal{N}=2 \) superconformal blocks and bosonic Virasoro conformal blocks, which allows us to analyze the crossing equations for BPS 4-point functions in unitary (2, 2) superconformal theories numerically with semidefinite programming. We constrain gaps in the non-BPS spectrum through the operator product expansion of...

Short-term Internet search using makes people rely on search engines when facing unknown issues

The Internet search engines, which have powerful search/sort functions and ease of use features, have become an indispensable tool for many individuals. The current study is to test whether the short-term Internet search training can make people more dependent on it. Thirty-one subjects out of forty subjects completed the search training study which included a pre-test, a six-day...

Shortening anomalies in supersymmetric theories

We present new anomalies in two-dimensional \( \mathcal{N}=\left(2,2\right) \) superconformal theories. They obstruct the shortening conditions of chiral and twisted chiral multiplets at coincident points. This implies that marginal couplings cannot be promoted to background superfields in short representations. Therefore, standard results that follow from \( \mathcal{N}=\left(2...

Growing Slowly 1 locus encodes a PLS-type PPR protein required for RNA editing and plant development in Arabidopsis

Most pentatricopeptide repeat (PPR) proteins are involved in organelle post-transcriptional processes, including RNA editing. The PPR proteins include the PLS subfamily, containing characteristic triplets of P, L, and S motifs; however, their editing mechanisms and roles in developmental processes are not fully understood. In this study, we isolated the Arabidopsis thaliana...

Deformations with maximal supersymmetries part 2: off-shell formulation

Continuing our exploration of maximally supersymmetric gauge theories (MSYM) deformed by higher dimensional operators, in this paper we consider an off-shell approach based on pure spinor superspace and focus on constructing supersymmetric deformations beyond the first order. In particular, we give a construction of the Batalin-Vilkovisky action of an all-order non-Abelian Born...

Off-shell hydrodynamics from holography

We outline a program for obtaining an action principle for dissipative fluid dynamics by considering the holographic Wilsonian renormalization group applied to systems with a gravity dual. As a first step, in this paper we restrict to systems with a non-dissipative horizon. By integrating out gapped degrees of freedom in the bulk gravitational system between an asymptotic...

Interpolating the Coulomb phase of little string theory

We study up to 8-derivative terms in the Coulomb branch effective action of (1, 1) little string theory, by collecting results of 4-gluon scattering amplitudes from both perturbative 6D super-Yang-Mills theory up to 4-loop order, and tree-level double scaled little string theory (DSLST). In previous work we have matched the 6-derivative term from the 6D gauge theory to DSLST...

Supersymmetry Constraints and String Theory on K3

We study supervertices in six dimensional (2, 0) supergravity theories, and derive supersymmetry non-renormalization conditions on the 4- and 6-derivative four-point couplings of tensor multiplets. As an application, we obtain exact non-perturbative results of such effective couplings in type IIB string theory compactified on K3 surface, extending previous work on type II...

A low temperature expansion for matrix quantum mechanics

We analyze solutions to loop-truncated Schwinger-Dyson equations in massless \( \mathcal{N}=2 \) and \( \mathcal{N}=4 \) Wess-Zumino matrix quantum mechanics at finite temperature, where conventional perturbation theory breaks down due to IR divergences. We find a rather intricate low temperature expansion that involves fractional power scaling in the temperature, based on a...

Little string amplitudes (and the unreasonable effectiveness of 6D SYM)

We study tree level scattering amplitudes of four massless states in the double scaled little string theory, and compare them to perturbative loop amplitudes in six-dimensional super-Yang-Mills theory. The little string amplitudes are computed from correlators in the cigar coset CFT and in \( \mathcal{N} \) = 2 minimal models. The results are expressed in terms of integrals of...

Identification of host proteins interacting with the integrin-like A domain of Toxoplasma gondii micronemal protein MIC2 by yeast-two-hybrid screening

Background Toxoplasma gondii is an obligate intracellular protozoan, causing the important zoonosis toxoplasmosis. This parasite utilizes a unique form of locomotion called gliding motility to find and invade host cells. The micronemal adhesin MIC2 plays critical roles in these processes by binding to substrates and host cell receptors using its extracellular adhesive domains...

EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer

Background GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Gprc5a– knockout mice develop spontaneous lung cancer, indicating Gprc5a is a lung tumor suppressor gene. GPRC5A expression is frequently suppressed in majority of non-small cell lung cancers (NSCLCs), however, elevated GPRC5A is still observed in a small portion of NSCLC cell...

Adaptive evolution and divergent expression of heat stress transcription factors in grasses

Background Heat stress transcription factors (Hsfs) regulate gene expression in response to heat and many other environmental stresses in plants. Understanding the adaptive evolution of Hsf genes in the grass family will provide potentially useful information for the genetic improvement of modern crops to handle increasing global temperatures. Results In this work, we performed a...

Identification of two novel HSP90 proteins in Babesia orientalis: molecular characterization, and computational analyses of their structure, function, antigenicity and inhibitor interaction

Background HSP90 protects the cells from heat stress and facilitates protein maturation and stability. The full genome sequences of piroplasms contain two putative HSP90 proteins, which are yet uncharacterized. To this end, the two putative HSP90 proteins of Babesia orientalis were identified and characterized by molecular and in silico methods. Methods The two putative proteins...