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Existence and regularity of solutions to a quasilinear elliptic problem involving variable sources

The authors of this paper prove the existence and regularity results for the homogeneous Dirichlet boundary value problem to the equation − div ( | ∇ u | p − 2 ∇ u ) = f ( x ) u α ( x ) $-\operatorname{div}(|\nabla u|^{p-2}\nabla u)=\frac{f(x)}{u ^{\alpha(x)}}$ with f ∈ L m ( Ω ) $f\in L^{m}(\Omega)$ ( m ⩾ 1 $m\geqslant1$ ) and α ( x ) > 0 $\alpha(x)>0$ . Due to the nonlinearity...

Existence,uniqueness, and nonexistence of solutions to nonlinear diffusion equations with p ( x , t ) -Laplacian operator

The aim of this paper is to deal with the existence and nonexistence of weak solutions to the initial and boundary value problem for u t = div ( | ∇ u | p ( x , t ) − 2 ∇ u + b ( x , t ) ∇ u ) + f ( u ) . By constructing suitable function spaces and applying the method of Galerkin’s approximation as well as weak convergence techniques, the authors prove the existence of local...

Correction: The New Face of the Old Molecules: Crustin Pm4 and Transglutaminase Type I Serving as RNPs Down-Regulate Astakine-Mediated Hematopoiesis

Vinu S. Siva Chia-Ying Chu Huai- Jen Tsai Yen-Ling Song OPEN ACCESS - The authors would like to correct Fig 7, as errors were introduced in the preparation of this figure for publication. The GAPDH

Daily rhythmicity of clock gene transcript levels in fast and slow muscle fibers from Chinese perch (Siniperca chuatsi)

Background Clock genes are considered to be the molecular core of biological clock in vertebrates and they are directly involved in the regulation of daily rhythms in vertebrate tissues such as skeletal muscles. Fish myotomes are composed of anatomically segregated fast and slow muscle fibers that possess different metabolic and contractile properties. To date, there is no report...

Existence of solutions to a class of quasilinear elliptic problems with nonlinear singular terms

The authors of this paper deal with the existence of weak solutions to the homogenous boundary value problem for the equation −div(|∇u|p−2∇u)=f(x)uα with f∈Lm(Ω) and α⩾1. The authors prove the existence of solutions in W01,p(Ω) for suitable m and α.MSC: 35J62, 35B25, 76D03.

Syphilitic orchitis mimicking a testicular tumor in a clinically occult HIV-infected young man: a case report with emphasis on a challenging pathological diagnosis

Background Syphilitic orchitis is a rare manifestation of gumma in tertiary syphilis, microscopically typically characterized by multiple discrete granulomas with central necrosis and peripheral fibrosis. We report a case of syphilitic orchitis mimicking a testicular tumor with atypical histological features. Case presentation A 33-year-old clinically occult HIV-infected man had...

Identification of human immunodeficiency virus type 1 (HIV-1) gp120-binding sites on scavenger receptor cysteine rich 1 (SRCR1) domain of gp340

Background gp340, a member of scavenger receptor cysteine rich family encoded by Deleted in Malignant Brain Tumors 1 (DMBT1), is an important component in innate immune defense. The first scavenger receptor cysteine rich domain (SRCR1) of gp340 has been shown to inhibit HIV-1 infection through binding to the N-terminal flank of the V3 loop of HIV-1 gp120. Results Through homology...

Detrended Fluctuation Analysis of Heart Rate Dynamics Is an Important Prognostic Factor in Patients with End-Stage Renal Disease Receiving Peritoneal Dialysis

Background and Objectives Patients with severe kidney function impairment often have autonomic dysfunction, which could be evaluated noninvasively by heart rate variability (HRV) analysis. Nonlinear HRV parameters such as detrended fluctuation analysis (DFA) has been demonstrated to be an important outcome predictor in patients with cardiovascular diseases. Whether cardiac...

Is Zolpidem Associated with Increased Risk of Fractures in the Elderly with Sleep Disorders? A Nationwide Case Cross-Over Study in Taiwan

Background We conducted a study using a case-crossover design to clarify the risk of acute effects of zolpidem and benzodiazepine on all-sites of fractures in the elderly. Design of study Case-crossover design. Methods and Materials Elderly enrollees (n = 6010) in Taiwan’s National Health Insurance Research Database with zolpidem or benzodiazepine use were analyzed for the risk...

Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells

Because of their pluripotent characteristics, human induced pluripotent stem cells (iPSCs) possess great potential for therapeutic application and for the study of degenerative disorders. These cells are generated from normal somatic cells, multipotent stem cells, or cancer cells. They express embryonic stem cell markers, such as OCT4, SOX2, NANOG, SSEA-3, SSEA-4, and REX1, and...

Association between Gastroenterological Malignancy and Diabetes Mellitus and Anti-Diabetic Therapy: A Nationwide, Population-Based Cohort Study

Background The relationship between diabetes mellitus (DM) and cancer incidence has been evaluated in limited kinds of cancer. The effect of anti-diabetic therapy (ADT) on carcinogenesis among diabetic patients is also unclear. Materials and Methods Using population-based representative insurance claims data in Taiwan, 36,270 DM patients and 145,080 comparison subjects without DM...

MicroRNA-138 Suppresses Neutrophil Gelatinase-Associated Lipocalin Expression and Inhibits Tumorigenicity

The expression of neutrophil gelatinase-associated lipocalin (NGAL) is up-regulated in some cancers; therefore NGAL has potential as a tumor biomarker. Although the regulation mechanism for this is unknown, one study has shown that it is likely to involve a microRNA (miRNA). Here, we investigate the relation between miRNA expression and NGAL expression, and the role of NGAL in...

Effect of data homogenization on estimate of temperature trend: a case of Huairou station in Beijing Municipality

Daily minimum temperature (Tmin) and maximum temperature (Tmax) data of Huairou station in Beijing from 1960 to 2008 are examined and adjusted for inhomogeneities by applying the data of two nearby reference stations. Urban effects on the linear trends of the original and adjusted temperature series are estimated and compared. Results show that relocations of station cause...

Bronchial asthma is associated with increased risk of chronic kidney disease

Hui-Ling Huang Shinn-Ying Ho Chien-Hsun Li Fang-Ying Chu Li-Ping Ciou Hua-Chin Lee Wen-Liang Chen Nian-Sheng Tzeng 1 0 325 , Sec 2, Cheng-Gong RdNei- Hu District, Taipei City , Taiwan 1 Department of

Comparison of diffusion-weighted imaging and contrast-enhanced T1-weighted imaging on a single baseline MRI for demonstrating dissemination in time in multiple sclerosis

Background The 2010 Revisions to the McDonald Criteria have established that dissemination in time (DIT) of multiple sclerosis (MS) can be demonstrated by simultaneous presence of asymptomatic gadolinium-enhancing and nonenhancing lesions on a single magnetic resonance imaging (MRI). However, gadolinium-based contrast agents (GBCAs) have contraindications. Diffusion-weighted...

Lower irritation microemulsion-based rotigotine gel: formulation optimization and in vitro and in vivo studies

,1 Sheng-Ying Chu,1 Wen-Wen Zhang,1 Ai-Ping Wang,1,2 Wen-Yan Wang,2 Kao-Xiang Sun1 1School of Pharmacy, Yantai University, 2State Key Laboratory of Long-acting and Targeting Drug Delivery System

idTarget: a web server for identifying protein targets of small chemical molecules with robust scoring functions and a divide-and-conquer docking approach

Identification of possible protein targets of small chemical molecules is an important step for unravelling their underlying causes of actions at the molecular level. To this end, we construct a web server, idTarget, which can predict possible binding targets of a small chemical molecule via a divide-and-conquer docking approach, in combination with our recently developed scoring...

Lignosulfonic Acid Exhibits Broadly Anti-HIV-1 Activity – Potential as a Microbicide Candidate for the Prevention of HIV-1 Sexual Transmission

Some secondary metabolites from plants show to have potent inhibitory activities against microbial pathogens, such as human immunodeficiency virus (HIV), herpes simplex virus (HSV), Treponema pallidum, Neisseria gonorrhoeae, etc. Here we report that lignosulfonic acid (LSA), a polymeric lignin derivative, exhibits potent and broad activity against HIV-1 isolates of diverse...