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Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PD

Cognitive impairment is a common disabling symptom in PD. Unlike motor symptoms, the mechanism underlying cognitive dysfunction in Parkinson’s disease (PD) remains unclear and may involve multiple pathophysiological processes. Resting state functional magnetic resonance imaging (rs-fMRI) is a fast-developing research field, and its application in cognitive impairments in PD is...

A comparative study on corrosion kinetic parameter estimation methods for the early stage corrosion of Q345B steel in 3.5wt% NaCl solution

Jin Corrosion kinetic parameters play an important role in researchers' ability to understand and predict corrosion behavior. The corrosion kinetic parameters of structural steel Q345B specimens

Comparing DIF methods for data with dual dependency

Background The current study compared four differential item functioning (DIF) methods to examine their performances in terms of accounting for dual dependency (i.e., person and item clustering effects) simultaneously by a simulation study, which is not sufficiently studied under the current DIF literature. The four methods compared are logistic regression accounting neither...

Analysis of Th17-associated cytokines and clinical correlations in patients with dry eye disease

We aimed to investigate the expressions of three Th17-associated cytokines, interleukin (IL)-17A, IL-6 and IL-23, in protein and mRNA levels and their correlations with ocular surface parameters in patients with dry eye disease (DED) through a small sample size case control study. A total of 45 female subjects were divided into Sjögren’s syndrome (SS) DED group, non-Sjögren’s...

The Effect of Pudilan Anti-Inflammatory Oral Liquid on the Treatment of Mild Recurrent Aphthous Ulcers

Received 15 February 2017; Revised 2 April 2017; Accepted 12 April 2017; Published 3 May 2017 Academic Editor: Ken Yasukawa Copyright © 2017 Ying Jin et al. This is an open access article distributed ... authors declare that they have no conflicts of interest regarding the publication of this paper. Authors’ Contributions Ying Jin and Xiaoping Lin participated in literature search, study design, data

Comparison of the Optical Quality between Small Incision Lenticule Extraction and Femtosecond Laser LASIK

Academic Editor: Vasilios F. Diakonis Copyright © 2016 Ying Jin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

Single-stranded DNA binding protein Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells

Background Intrinsic factors and extrinsic signals which control unlimited self-renewal and developmental pluripotency in embryonic stem cells (ESCs) have been extensively investigated. However, a much smaller number of factors involved in extra-embryonic trophoblast differentiation from ESCs have been studied. In this study, we investigated the role of the single-stranded DNA...

Reorganization of a synthetic microbial consortium for one-step vitamin C fermentation

Background In the industry, the conventional two-step fermentation method was used to produce 2-keto-l-gulonic acid (2-KGA), the precursor of vitamin C, by three strains, namely, Gluconobacter oxydans, Bacillus spp. and Ketogulonicigenium vulgare. Despite its high production efficiency, the long incubation period and an additional second sterilization process inhibit the further...

Upregulation of microRNA-98 increases radiosensitivity in esophageal squamous cell carcinoma

Although radiation resistance is a common challenge in the clinical treatment of esophageal squamous cell carcinoma (ESCC), an effective treatment strategy has yet to be developed. Aberrant expression of microRNAs (miRNAs) is responsible for cancer sensitivity to radiation. In this study, we aimed to identify the miRNAs that are associated with radioresistance in ESCC. We used a...

The target therapy of ovarian clear cell carcinoma

The target therapy of ovarian clear cell carcinoma Ying Jin, Yan Li, Lingya Pan Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and

New predictions on the mass of the 1−+ light hybrid meson from QCD sum rules

Abstract We calculate the coefficients of the dimension-8 quark and gluon condensates in the current-current correlator of 1−+ light hybrid current \( g\overline{q}(x){\gamma}_{\nu }i{G}_{\mu \nu }(x)q(x) \). With inclusion of these higher-power corrections and updating the input parameters, we re-analyze the mass of the 1−+ light hybrid meson from Monte-Carlo based QCD sum rules...

Guiding migration of transplanted glial progenitor cells in the injured spinal cord

AffiliationsSpinal Cord Research Center, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USAXiao-bing Yuan, Ying Jin, Christopher Haas, Lihua Yao, Kazuo Hayakawa ...  & Itzhak FischerHussman Institute for Autism, Baltimore, MD, USAXiao-bing Yuan, Yue Wang & Chunlei Wang AuthorsSearch for Xiao-bing Yuan in:Nature Research journals • PubMed • Google ScholarSearch for Ying

Atorvastatin prevents Aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting Tau cleavage

degeneration. Nevertheless, these observations provide further evidence of the beneficial effects of statins in the prevention of AβO-induced toxicity in central neurons. Author contribution Ying JIN ... designed the research; Ling-ling ZHANG, Hai-juan SUI, and Zhou LIU performed the research; Hai-juan SUI analyzed the data; and Ying JIN wrote the paper. References 1. Parihar MS, Hemnani T. Alzheimer's

Genome Sequence of Bacillus endophyticus and Analysis of Its Companion Mechanism in the Ketogulonigenium vulgare-Bacillus Strain Consortium

Bacillus strains have been widely used as the companion strain of Ketogulonigenium vulgare in the process of vitamin C fermentation. Different Bacillus strains generate different effects on the growth of K. vulgare and ultimately influence the productivity. First, we identified that Bacillus endophyticus Hbe603 was an appropriate strain to cooperate with K. vulgare and the...

Inhibition of lignin-derived phenolic compounds to cellulase

Background Lignin-derived phenolic compounds are universal in the hydrolysate of pretreated lignocellulosic biomass. The phenolics reduce the efficiency of enzymatic hydrolysis and increase the cost of ethanol production. We investigated inhibition of phenolics on cellulase during enzymatic hydrolysis using vanillin as one of the typical lignin-derived phenolics and Avicel as...

Engineering Yarrowia lipolytica for Campesterol Overproduction

Campesterol is an important precursor for many sterol drugs, e.g. progesterone and hydrocortisone. In order to produce campesterol in Yarrowia lipolytica, C-22 desaturase encoding gene ERG5 was disrupted and the heterologous 7-dehydrocholesterol reductase (DHCR7) encoding gene was constitutively expressed. The codon-optimized DHCR7 from Rallus norvegicus, Oryza saliva and Xenapus...

Alleviating Redox Imbalance Enhances 7-Dehydrocholesterol Production in Engineered Saccharomyces cerevisiae

Maintaining redox balance is critical for the production of heterologous secondary metabolites, whereas on various occasions the native cofactor balance does not match the needs in engineered microorganisms. In this study, 7-dehydrocholesterol (7-DHC, a crucial precursor of vitamin D3) biosynthesis pathway was constructed in Saccharomyces cerevisiae BY4742 with endogenous...

Ethylenediamine pretreatment changes cellulose allomorph and lignin structure of lignocellulose at ambient pressure

Background Pretreatment of lignocellulosic biomass is essential to increase the cellulase accessibility for bioconversion of lignocelluloses by breaking down the biomass recalcitrance. In this work, a novel pretreatment method using ethylenediamine (EDA) was presented as a simple process to achieve high enzymatic digestibility of corn stover (CS) by heating the biomass–EDA...

Increasing proline and myo-inositol improves tolerance of Saccharomyces cerevisiae to the mixture of multiple lignocellulose-derived inhibitors

Background The development of robust microbes with tolerance to the combined lignocellulose-derived inhibitors is critical for the efficient cellulosic ethanol production. However, the lack of understanding on the inhibition mechanism limited the rational engineering of tolerant strain. Here, through the metabolomic analysis of an adaptation process of Saccharomyces cerevisiae to...