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Dihydroisocoumarins from Radix Glycyrrhizae

BackgroundRadix Glycyrrhizae is the rhizome of Glycyrrhiza inflata Bat., Glycyrrhiza uralensis Fisch. or Glycyrrhiza glabra L. The present paper describes the isolation and the structural elucidation of three new dihydroisocoumarins obtained from the 70% EtOH extract of Radix Glycyrrhizae. And the cytotoxic activities of these new compounds were also evaluated using four cell...

Prognostic value of microRNAs in colorectal cancer: a meta-analysis

Prognostic value of microRNAs in colorectal cancer: a meta-analysis Song Gao,1,* Zhi-Ying Zhao,2,* Rong Wu,1 Yue Zhang,3 Zhen-Yong Zhang1 1Second Department of Clinical Oncology, Shengjing Hospital

A Generalized Mathematical Model for the Fracture Problem of the Suspended Highway

In order to answer dangling fracture problems of highway, the suspended pavement equivalent for non - suspended pavement, through the special boundary conditions has been suspended highway stress field of expression, in accordance with the 3D fracture model of crack formation, and establish a vacant, a general mathematics model for fracture problems of highway and analysis in...

The Aqueous Extract of Gynura divaricata (L.) DC. Improves Glucose and Lipid Metabolism and Ameliorates Type 2 Diabetes Mellitus

Shengpan Hou,1 Ying Zhao,1 Bo Zhang,1 and Cheng Yang1,3,4 1High-Throughput Molecular Drug Discovery Center, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China 2School of Chinese

Drug-induced anaphylaxis in China: a 10 year retrospective analysis of the Beijing Pharmacovigilance Database

especially with antibiotics, TCM, radiocontrast and antineoplastic agents. China; Clinical features; Drug category; Drug-induced anaphylaxis; Pharmacovigilance - Ying Zhao and Shusen Sun have contributed

Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways

is the S1 Table title. This is the S1 Table legend. (PDF) 15 / 19 Author Contributions Conceptualization: Jian-Ping Dai. Data curation: Qian-Wen Wang, Jiang-Tao Sheng, Li-Ming Gu, Ying Zhao, Jian ... , Li-Ming Gu, Ying Zhao, Cheng Chen, Jian-Ping Dai. Project administration: Cheng Chen, Jian-Ping Dai. Resources: Jian-Ping Dai. Software: Yun Su, Xiao-Xuan Chen. Supervision: Xiao-Xuan Chen, Kang

Endosphere microbiome comparison between symptomatic and asymptomatic roots of Brassica napus infected with Plasmodiophora brassicae

valuable comments. 15 / 19 Author Contributions Formal analysis: Ying Zhao, Huiquan Liu. Investigation: Ying Zhao, Zhixiao Gao, Binnian Tian, Kai Bi, Tao Chen. Methodology: Yanping Fu. Project ... administration: Daohong Jiang. Resources: Jiatao Xie, Jiasen Cheng, Yanping Fu. Supervision: Daohong Jiang. Writing ± original draft: Ying Zhao, Yanping Fu. Writing ± review & editing: Yanping Fu, Daohong

Intestinal microbiota and chronic constipation

Chronic constipation is a prevalent, burdensome gastrointestinal disorder whose aetiology and pathophysiology remains poorly understood and is most likely multifactorial. Differences in the composition of the intestinal microbiota have been demonstrated when constipated patients and healthy controls have been compared. Growing evidence indicates that alterations of intestinal...

Transform Group of Monotonic Functions with the Same Monotonicity on [ \(-\) 1, 1] and Operations of Fuzzy Numbers

Operations of fuzzy numbers are the main content of the fuzzy mathematical analysis. This paper defines the transformation of monotonic bounded functions with same monotonicity on the symmetric interval [\(-\)1, 1], and the four fundamental operations of fuzzy numbers based on the fuzzy structured element. It not only make operations of fuzzy numbers easier, but also start a new...

Leveraging Lexical Link Analysis (LLA) To Discover New Knowledge

Lexical Link Analysis (LLA) is a form of text mining in which word meanings represented in lexical terms (e.g., word pairs) are treated as if they are in a community of a word network. LLA can provide automated awareness for analyzing text data and reveal previously unknown, data-driven themed connections. We applied LLA to develop authentic archetypes and conversely determine...

Rapid and simultaneous detection of common aneuploidies by quadruplex real-time polymerase chain reaction combined with melting curve analysis

Background During the prenatal period, the number variation of chromosomes 13, 18, 21, X and Y accounts for more than 80% of the clinically significant chromosomal abnormalities diagnosed. Rapid tests for prenatal diagnosis of these abnormalities can improve pregnancy management and alleviate parental anxiety. Here, we present a molecular alternative method for detecting common...

Electron transport layer driven to improve the open-circuit voltage of CH3NH3PbI3 planar perovskite solar cells

Suitable electron transport layers are essential for high performance planar perovskite heterojunction solar cells. Here, we use ZnO electron transport layer sputtered under oxygen-rich atmosphere at room temperature to decrease the hydroxide and then suppress decomposition of perovskite films. The perovskite films with improved crystallinity and morphology are achieved. Besides...

Is the Taklimakan Desert Highway Shelterbelt Sustainable to Long-Term Drip Irrigation with High Saline Groundwater?

Freshwater resources are scarce in desert regions. Highly saline groundwater of different salinity is being used to drip irrigate the Taklimakan Desert Highway Shelterbelt with a double-branch-pipe system controlling the irrigation cycles. In this study, to evaluate the dynamics of soil moisture and salinity under the current irrigation system, soil samples were collected to a 2...

Functional Anatomy of Recognition of Chinese Multi-Character Words: Convergent Evidence from Effects of Transposable Nonwords, Lexicality, and Word Frequency

This fMRI study aimed to identify the neural mechanisms underlying the recognition of Chinese multi-character words by partialling out the confounding effect of reaction time (RT). For this purpose, a special type of nonword—transposable nonword—was created by reversing the character orders of real words. These nonwords were included in a lexical decision task along with regular...

Assessment of gray and white matter structural alterations in migraineurs without aura

Background Migraine constitute a disorder characterized by recurrent headaches, and have a high prevalence, a high socio-economic burden and severe effects on quality of life. Our previous fMRI study demonstrated that some brain regions are functional alterations in migraineurs. As the function of the human brain is related to its structure, we further investigated white and gray...

Continuous extrusion and rolling forming of copper strips

Continuous extrusion and rolling technology was proposed as a new strip production technology. It conducts a hot rolling process using waste heat after continuous extrusion. The continuous extrusion and rolling forming was simulated with DEFORM-3DT. Influences of extrusion wheel velocity and rolling reduction on the continuous extrusion and rolling forming were analyzed. It was...

MECP2 duplication syndrome in a Chinese family

Background Methyl-CpG-binding protein 2 (MeCP2) is a key transcriptional regulator of gene expression in the maintenance and development of the central nervous system. Loss- or gain-function of this gene may contribute to neurodevelopmental disorders. The aim of this study is to delineate the clinical characteristics of MECP2 duplication syndrome and the hereditary mechanism in a...

Targeted optimization of central carbon metabolism for engineering succinate production in Escherichia coli

Background Succinate is a kind of industrially important C4 platform chemical for synthesis of high value added products. Due to the economical and environmental advantages, considerable efforts on metabolic engineering and synthetic biology have been invested for bio-based production of succinate. Precursor phosphoenolpyruvate (PEP) is consumed for transport and phosphorylation...

SMILE and Wavefront-Guided LASIK Out-Compete Other Refractive Surgeries in Ameliorating the Induction of High-Order Aberrations in Anterior Corneal Surface

,1 Zheng-yu Gu,1 Bing-ying Zhao,1 and Yi Liao3 1Department of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China 2Department of Ophthalmology, The Hospital