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10 papers found.
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Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1

Casein kinase 1 delta (CK1δ) is a conserved serine/threonine protein kinase that regulates diverse cellular processes. Mice lacking CK1δ have a perinatal lethal phenotype and typically weigh 30% less than their wild type littermates. However, the causes of death and small size are unknown. We observed cells with abnormally large nuclei in tissue from Csnk1d null embryos, and...

Fleshing out the skeletal system

, Boulder, CO 80309-0347 , USA Yingzi Yang Edited by Olivier Pourqui Cold Spring Harbor Laboratory Press (2009) 365 pages ISBN 978-087969825-6 61.75/$95 (hardcover) T N E M P O L E V E D - the descriptive

Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals

The role of planar cell polarity (PCP) signalling in neural crest (NC) development is unclear. The PCP dependence of NC cell migration has been reported in Xenopus and zebrafish, but NC migration has not been studied in mammalian PCP mutants. Vangl2Lp/Lp mouse embryos lack PCP signalling and undergo almost complete failure of neural tube closure. Here we show, however, that NC...

The Wnt/β-Catenin Pathway Interacts Differentially with PTHrP Signaling to Control Chondrocyte Hypertrophy and Final Maturation

Sequential proliferation, hypertrophy and maturation of chondrocytes are required for proper endochondral bone development and tightly regulated by cell signaling. The canonical Wnt signaling pathway acts through β-catenin to promote chondrocyte hypertrophy whereas PTHrP signaling inhibits it by holding chondrocytes in proliferating states. Here we show by genetic approaches that...

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

Kinglun Kingston Mak Henry M. Kronenberg Pao-Tien Chuang Susan Mackem Yingzi Yang ) Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of

LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth

Yang ) 2 0 Present address: Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University , 7 Divinity Avenue, Cambridge, MA 02138 , USA 1 Section on Molecular