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28 papers found.
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Capability of leaf interdigitation with different inverse planning strategies in Monaco: an investigation of representative tumour sites

Purpose The aim of this study was to experimentally assess the dosimetric impact of leaf interdigitation using different inverse treatment strategies for representative tumour sites and to identify the situations in which leaf interdigitation can benefit these tumour sites. Material and methods Sixty previously treated patients (15 nasopharyngeal carcinoma (NPC), 15 multiple brain ...

Sedimentary characteristics and processes of the Paleogene Dainan Formation in the Gaoyou Depression, North Jiangsu Basin, eastern China

In this paper, the type, vertical evolution, and distribution pattern of sedimentary facies of the Paleogene Dainan Formation in the Gaoyou Depression of the North Jiangsu Basin are studied in detail. Results show that fan delta, delta, nearshore subaqueous fan, and lacustrine facies developed during the Dainan Formation period and their distribution pattern was mainly controlled ...

Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats

Background Diabetic nephropathy is one of the most serious complications in patients with diabetes. At present, there are no satisfactory treatments available for diabetic nephropathy. Stem cells are currently the main candidates for the development of new treatments for diabetic nephropathy, as they may exert their therapeutic effects mainly through paracrine mechanisms. Exosomes ...

Tree-Ring Dating of the Reshui-1 Tomb in Dulan County, Qinghai Province, North-West China

Tuyuhun and Tubo were two important states that thrived in north-western China during AD 311-900 in parallel with the Han Chinese dynasties of Sui and Tang periods. The Reshui Tomb Cluster located in Dulan County of the north-eastern Tibetan Plateau is an important cultural relic of the Tuyuhun-Tubo age. The official excavations of the Reshui tombs were regarded as top events in ...

Porta hepatic schwannoma: case report and a 30-year review of the literature yielding 15 cases

and ZSS revised the manuscript. All authors read and approved the final manuscript. Acknowledgements First of all, I would like to extend my sincere gratitude to my supervisor, Sheng-yong Yin, for his

A comparison of the different 3D CT scanning modes on the GTV delineation for the solitary pulmonary lesion

Objectives To investigate the impacts of the different three-dimensional CT (3DCT) scanning modes on the GTV delineation for solitary pulmonary lesion (SPL) based on four-dimensional CT (4DCT), and to evaluate the feasibility of using the spiral CT scan in CT simulation. Materials and methods Twenty-one patients with SPL underwent axial CT scan, spiral CT scan and 4DCT simulation ...

Gradient-based delineation of the primary GTV on FLT PET in squamous cell cancer of the thoracic esophagus and impact on radiotherapy planning

Background To validate a gradient-based segmentation method for gross tumor volume(GTV) delineation on 8F-fluorothymidine (FLT)positron emission tomography (PET)/ computer tomography (CT) in esophageal squamous cell cancer through pathologic specimen, in comparison with standardized uptake values (SUV) threshold-based methods and CT. The corresponding impact of this GTV delineation ...

Feasibility and potential benefits of defining the internal gross tumor volume of hepatocellular carcinoma using contrast-enhanced 4D CT images obtained by deformable registration

authors have read and approved the final manuscript. Hua Xu, Guanzhong Gong, Hong Wei, Lusheng Chen, Jinhu Chen, Jie Lu, Tonghai Liu, Jian Zhu, Yong Yin carried out this study jointly, and Yong Yin

Assessment of anatomical and dosimetric changes by a deformable registration method during the course of intensity-modulated radiotherapy for nasopharyngeal carcinoma

Jie LU Yidong MA Jinhu CHEN Liming WANG Guifang ZHANG Mukun ZHAO Yong YIN - Radiotherapy (RT) is a critical component in the current management of patients with nasopharyngeal carcinoma (NPC

The feasibility of evaluating radiation dose to the heart by integrating kilovoltage-cone beam computed tomography in stereotactic body radiotherapy of early non-small-cell lung cancer patients

Background To investigate the feasibility of contouring the planning risk organ volume (PRV) for the heart, and to determine the probability of evaluating radiation dose to the heart using kilovoltage-cone beam computed tomography (kV-CBCT) in early-stage non-small-cell lung cancer (NSCLC) patients, who received stereotactic body radiotherapy (SBRT). Materials and methods Seventeen ...

Synthesis, Structure and Antibacterial Activity of Potent DNA Gyrase Inhibitors: N′-Benzoyl-3-(4-Bromophenyl)-1H-Pyrazole-5-Carbohydrazide Derivatives

A total of 19 novel (3a–3s) N′-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide analogs were designed, synthesized, and evaluated for biological activities as potential DNA gyrase inhibitors. The results showed that compound 3k can strongly inhibit Staphylococcus aureus DNA gyrase and Bacillus subtilis DNA gyrase (with IC50 of 0.15 µg/mL and 0.25 µg/mL, respectively). ...

Reduced lung dose during radiotherapy for thoracic esophageal carcinoma: VMAT combined with active breathing control for moderate DIBH

, and Chengxin Liu carried out the statistics of this study, and Yong Yin administrated the study. All authors participated in the sequence alignment and drafted the manuscript.

MRI Assessment of Lumbar Intervertebral Disc Degeneration with Lumbar Degenerative Disease Using the Pfirrmann Grading Systems

Background To evaluate by MRI intervertebral disc degeneration in patients with lumbar degenerative disease using the Pfirrmann grading system and to determine whether Modic changes correlated with the Pfirrmann grades and modified Pfirrmann grades of disc degeneration. Methods The clinical data of 108 surgical patients with lumbar degenerative disease were reviewed and their ...

Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population

Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Currently, numerous genetic loci of SLE have been confirmed. Here we try to further explore additional genes contributing to SLE susceptibility in this study. Methods Forty nine single nucleotide polymorphisms (SNPs) with moderate-risk for SLE in previous study were genotyped in a large-scale ...

RapidArc radiotherapy for whole pelvic lymph node in cervical cancer with 6 and 15 MV: a treatment planning comparison with fixed field IMRT

De-Yin ZHAI Yong YIN Guan-Zhong GONG Tong-Hai LIU Jin-Hu CHEN Chang-Sheng MA Jie LU Dosimetric differences were investigated among single and dual arc RapidArc and fixed-field intensitymodulated

Dosimetric differences among volumetric modulated arc radiotherapy (RapidArc) plans based on different target volumes in radiotherapy of hepatocellular carcinoma

We investigated the dosimetric differences among volumetric-modulated arc radiotherapy (RapidArc, RA) plans designed for various target volumes in hepatocellular carcinoma (HCC). Ten HCC patients underwent 3D-CT scanning at free breathing (FB), 3D-CT at end inspiration hold (EIH) assisted by an Active Breathing Coordinator (ABC), and 4D-CT scanning. Gross tumor volumes (GTVs) were ...

Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance

Background Amino acid insertions and deletions in proteins are considered relatively rare events, and their associations with the evolution and adaptation of organisms are not yet understood. In this study, we undertook a systematic analysis of over 214,000 polypeptides from 32 nematode species and identified insertions and deletions unique to nematode proteins in more than 1000 ...

Association Analysis of Single Nucleotide Polymorphisms at Five Loci: Comparison between Atopic Dermatitis and Asthma in the Chinese Han Population

Atopic diseases, such as atopic dermatitis (AD) and asthma, are closely related to clinical phenotypes with hypersensitivity, and often share some similar genetic and pathogenic bases. Our recent GWAS identified three susceptibility gene/loci FLG (rs11204971 and rs3126085), 5q22.1 (rs10067777, rs7701890, rs13360927 and rs13361382) and 20q13.33 (rs6010620) to AD. The effect of these ...

Nematode.net update 2008: improvements enabling more efficient data mining and comparative nematode genomics

Nematode.net (http://nematode.net) is a publicly available resource dedicated to the study of parasitic nematodes. In 2000, the Genome Center at Washington University (GC) joined a consortium including the Nematode Genomics group in Edinburgh, and the Pathogen Sequencing Unit of the Sanger Institute to generate expressed sequence tags (ESTs) as an inexpensive and efficient solution ...