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The Chinese Medicine, Jiedu Recipe, Inhibits the Epithelial Mesenchymal Transition of Hepatocellular Carcinoma via the Regulation of Smad2/3 Dependent and Independent Pathways

The authors declare that there are no conflicts of interest. Authors’ Contributions Shufang Liang, Yong Zou, and Jingdong Gao contributed equally to this work and should be considered as co-first ... Zou,1 Jingdong Gao,2 Xiaolin Liu,1 Wanfu Lin,1 Zifei Yin,1 Juan Du,1 Ya’ni Zhang,1 Qunwei Chen,3 Shu Li,4 Binbin Cheng,1 and Changquan Ling1 1Department of Traditional Chinese Medicine, Changhai

Transcriptome analysis reveals the genetic basis underlying the biosynthesis of volatile oil, gingerols, and diarylheptanoids in ginger (Zingiber officinale Rosc.)

Background Ginger (Zingiber officinale Rosc.) is a popular flavoring that widely used in Asian, and the volatile oil in ginger rhizomes adds a special fragrance and taste to foods. The bioactive compounds in ginger, such as gingerols, diarylheptanoids, and flavonoids, are of significant value to human health because of their anticancer, anti-oxidant, and anti-inflammatory...

Constructing regional climate networks in the Amazonia during recent drought events

curation: Elbert E. N. Macau. Formal analysis: Heng Guo, AntoÃnio M. T. Ramos, Yong Zou, Shuguang Guan. Investigation: AntoÃnio M. T. Ramos, Yong Zou. Methodology: AntoÃnio M. T. Ramos, Elbert E. N. Macau ... , Yong Zou. Visualization: Heng Guo. Writing ± original draft: Yong Zou, Shuguang Guan. Writing ± review & editing: Elbert E. N. Macau, Yong Zou, Shuguang Guan. 13 / 16 14 / 16 15 / 16 1. Tsonis AA

Comparison between toric and spherical phakic intraocular lenses combined with astigmatic keratotomy for high myopic astigmatism

Background To compare the outcomes of a toric phakic intraocular lens (PIOL) and a spherical PIOL combined with astigmatic keratotomy (AK) for the correction of high myopic astigmatism. Methods This study enrolled patients with high myopic astigmatism, including 30 eyes (22 patients) that received a toric PIOL implantation (TICL group), and 32 eyes (24 patients) that received...

The distribution and function of human memory T cell subsets in lung cancer

The distribution and function of T lymphocytes in human lung cancer remain limited. In this study, we investigated the properties of human T cell subsets in the blood of non-small cell lung cancer (NSCLC) patients. We found a relatively normal level of CD4+ subsets in the blood of NSCLC patients, but CD8+ effector T cells increased and CD8+ effector memory cells declined compared...

Erzhi Pill® Repairs Experimental Liver Injury via TSC/mTOR Signaling Pathway Inhibiting Excessive Apoptosis

The present study aimed to investigate the mechanism of hepatoprotective effect of Erzhi Pill (EZP) on the liver injury via observing TSC/mTOR signaling pathway activation. The experimental liver injury was induced by 2-acetylaminofluorene (2-AAF) treatment combined with partial hepatectomy (PH). EZP treated 2-AAF/PH-induced liver injury by the therapeutic and prophylactic...

Prognostic value of decreased microRNA-133a in solid cancers: a meta-analysis

Prognostic value of decreased microRNA-133a in solid cancers: a meta-analysis Jian Xiao, Yong Zou, Xiaoxiao Lu, Bin Xie, Qiao Yu, Baimei He, Bixiu He, Qiong Chen Department of Geriatrics, Respiratory ... OncoTargets and Therapy Prognostic value of decreased microrna-133a in solid cancers: a meta-analysis 0 Jian Xiao Yong Zou Xiaoxiao lu Bin Xie Qiao Yu Baimei he Bixiu he Qiong chen 8 1 0 2 - l u J

Prognostic value of decreased FOXP1 protein expression in various tumors: a systematic review and meta-analysis

, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, ChinaJian Xiao, Bixiu He, Yong Zou, Xiaoxiao Lu, Mingxuan Xie, Wei Li & Qiong ChenDepartment of Respiratory Medicine, Xiangya ... Research journals • PubMed • Google ScholarSearch for Yong Zou in:Nature Research journals • PubMed • Google ScholarSearch for Xi Chen in:Nature Research journals • PubMed • Google ScholarSearch for Xiaoxiao

Comparative Transcriptomic Analysis of the Response to Cold Acclimation in Eucalyptus dunnii

Eucalyptus dunnii is an important macrophanerophyte with high economic value. However, low temperature stress limits its productivity and distribution. To study the cold response mechanisms of E. dunnii, 5 cDNA libraries were constructed from mRNA extracted from leaves exposed to cold stress for varying lengths of time and were evaluated by RNA-Seq analysis. The assembly of the...

NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure

Background and Aims Previous work conducted by our group has shown that the accumulation of hepatic natural killer (NK) cells and the up-regulation of natural cytotoxicity receptors (NKP30 and NKP46) on NK cells from patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) were correlated with disease progression in HBV-ACLF. The natural cytotoxicity...

Explosive synchronization as a process of explosive percolation in dynamical phase space

, ChinaXiyun Zhang, Yong Zou & Zonghua LiuCNR- Institute of Complex Systems, Via Madonna del Piano 10, 50019 Sesto Fiorentino, Florence, ItalyS. Boccaletti AuthorsSearch for Xiyun Zhang in:Nature Research ... journals • PubMed • Google ScholarSearch for Yong Zou in:Nature Research journals • PubMed • Google ScholarSearch for S. Boccaletti in:Nature Research journals • PubMed • Google ScholarSearch for Zonghua Liu

The Prognostic Value of Decreased LKB1 in Solid Tumors: A Meta-Analysis

Background Liver kinase B1 (LKB1) is a protein kinase that regulates the growth, integrity and polarity of mammalian cells. Recent studies have reported the prognostic value of decreased LKB1 expression in different tumors. However, the results of these studies remain controversial. Therefore, this meta-analysis was performed to more accurately estimate the role of decreased LKB1...

On the Estimation of Additive Interaction by Use of the Four-by-two Table and Beyond

additive interaction and thus face a real challenge of gene-environment interaction, that is, conducting appropriate inferences for disease prevention ( 5–7 ). ACKNOWLEDGMENTS Guang Yong Zou is a

Manipulation of the Porcine Epidemic Diarrhea Virus Genome Using Targeted RNA Recombination

Porcine epidemic diarrhea virus (PEDV) causes severe economic losses in the swine industry in China and other Asian countries. Infection usually leads to an acute, often lethal diarrhea in piglets. Despite the impact of the disease, no system is yet available to manipulate the viral genome which has severely hampered research on this virus until today. We have established a...

Reduction of Phosphorylated Synapsin I (Ser-553) Leads to Spatial Memory Impairment by Attenuating GABA Release after Microwave Exposure in Wistar Rats

Background Abnormal release of neurotransmitters after microwave exposure can cause learning and memory deficits. This study investigated the mechanism of this effect by exploring the potential role of phosphorylated synapsin I (p-Syn I). Methods Wistar rats, rat hippocampal synaptosomes, and differentiated (neuronal) PC12 cells were exposed to microwave radiation for 5 min at a...

The complexity of gene expression dynamics revealed by permutation entropy

Background High complexity is considered a hallmark of living systems. Here we investigate the complexity of temporal gene expression patterns using the concept of Permutation Entropy (PE) first introduced in dynamical systems theory. The analysis of gene expression data has so far focused primarily on the identification of differentially expressed genes, or on the elucidation of...

Effect of phenylhexyl isothiocyanate on aberrant histone H3 methylation in primary human acute leukemia

BackgroundWe have previously studied the histone acetylation in primary human leukemia cells. However, histone H3 methylation in these cells has not been characterized.MethodsThis study examined the methylation status at histone H3 lysine 4 (H3K4) and histone H3 lysine 9 (H3K9) in primary acute leukemia cells obtained from patients and compared with those in the non-leukemia and...

Ancient gene transfer from algae to animals: Mechanisms and evolutionary significance

Ting Ni 0 Jipei Yue Guiling Sun Yong Zou 0 Jianfan Wen 0 Jinling Huang 0 State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming

Proteomic-Based Insight into Malpighian Tubules of Silkworm Bombyx mori

Malpighian tubules (MTs) are highly specific organs of arthropods (Insecta, Myriapoda and Arachnida) for excretion and osmoregulation. In order to highlight the important genes and pathways involved in multi-functions of MTs, we performed a systematic proteomic analysis of silkworm MTs in the present work. Totally, 1,367 proteins were identified by one-dimensional gel...

Relapse Rate and Associated-Factor of Recurrence after Stopping NUCs Therapy with Different Prolonged Consolidation Therapy in HBeAg Positive CHB Patients

Background Many chronic hepatitis B (CHB) patients recur after off-therapy and have to accept prolonged consolidation therapy with NUCs. We investigated the rate of HBV relapse after stopping NUCs therapy with different time period of prolonged consolidation therapy in HBeAg positive CHB patients, and analyzed the associated-factor of recurrence. Methods We recruited 162 HBeAg...