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Niclosamide induces protein ubiquitination and inhibits multiple pro-survival signaling pathways in the human glioblastoma U-87 MG cell line

Morales. Methodology: Benxu Cheng. Project administration: Benxu Cheng. Resources: Benxu Cheng, Yonghong Zhang, Shizue Mito. Supervision: Benxu Cheng. Validation: Benxu Cheng. Visualization: Benxu ... Cheng, Liza Doreen Morales. Writing ± original draft: Benxu Cheng. Writing ± review & editing: Benxu Cheng, Liza Doreen Morales, Yonghong Zhang, Shizue Mito, Andrew Tsin. 15 / 18 States. Clin Cancer

Evaluating somatic tumor mutation detection without matched normal samples

Observations of recurrent somatic mutations in tumors have led to identification and definition of signaling and other pathways that are important for cancer progression and therapeutic targeting. As tumor cells contain both an individual’s inherited genetic variants and somatic mutations, challenges arise in distinguishing these events in massively parallel sequencing datasets. ...

Dissection of HY5/HYH expression in Arabidopsis reveals a root-autonomous HY5-mediated photomorphogenic pathway

roots of WT and hy5 mutants, related to S6D and S6E Fig. (XLSX) 12 / 15 Author Contributions Conceptualization: Chen Li, Guodong Wang, Lanlan Zheng. Data curation: Yonghong Zhang, Jiajing Wang ... , Jingwei Yang, Guodong Wang. Funding acquisition: Yonghong Zhang, Chen Li, Guodong Wang, Lanlan Zheng. Investigation: Yonghong Zhang, Guodong Wang, Lanlan Zheng. Methodology: Chen Li, Jiajing Wang, Guodong

Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance

Elucidating protective immunity against HCV is important for the development of a preventative vaccine. We hypothesize that spontaneous resolution of acute HCV infection offers clue to protective immune responses, and that DAA therapy affects the quality and quantity of HCV-specific T cell responses. To test these hypotheses, we performed T cell epitope mapping in 111 HCV-infected ...

High serum resistin associates with intrahepatic inflammation and necrosis: an index of disease severity for patients with chronic HBV infection

Background Studies have revealed that resistin plays a role as an intrahepatic cytokine with proinflammatory activities. This study investigated the association between serum resistin and fibrosis severity and the possible marker role of resistin in the inflammatory process of chronic hepatitis B. Methods In this study, 234 subjects with HBV infection were retrospectively selected, ...

Yalongjiang River Has Had an Important Role in the Dispersal and Divergence of Rosa soulieana in the Hengduan Mountains of China

Natural Science Foundation of China (31590823 to HS), National Natural Science Foundation of China (31260198 to HYJ), National Natural Science Foundation of China (31460050 Dr. Yonghong Zhang), Academic and

Clinical, biochemical and molecular analysis of two infants with familial chylomicronemia syndrome

Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disease due mainly to inherited deficiencies in the proteins or enzymes involved in the clearance of triglycerides from circulation. It usually happens in late childhood and adolescence, which can have serious consequences if misdiagnosed or untreated. In the present study, we investigated two Chinese male babies ...

Operational reliability evaluation of restructured power systems with wind power penetration utilizing reliability network equivalent and time-sequential simulation approaches

include the areas of power system reliability and planning, power system dynamics and control based on wide-area measurement systems (WAMS). Yonghong ZHANG received the Ph.D degree from Shanghai Jiaotong

NLRP3 inflammasome activation contributes to Listeria monocytogenes-induced animal pregnancy failure

Background Listeria monocytogenes (LM), a foodborne pathogen, can cause pregnancy failure in animals, especially in ruminants. Recent studies have shown that LM activates inflammasomes to induce IL-1β release in macrophages, however, whether the inflammasome activation regulates LM-induced pregnancy failure remains largely unknown. Here we used mouse model to investigate the ...

The interactive effect of diabetes and central obesity on stroke: a prospective cohort study of inner Mongolians

Background The relationship between central obesity and stroke is inconsistent in diabetic and non-diabetic populations. This indicates an interaction between diabetes and central obesity on stroke risk. The present study aimed to examine the interaction in a cohort of Inner Mongolians. Methods In this prospective cohort study, we assessed the interaction between diabetes and ...

Longitudinal Changes in Plasma Caspase-1 and Caspase-3 during the First 2 Years of HIV-1 Infection in CD4Low and CD4High Patient Groups

Over 95% of CD4 cell death occurs by Caspase-1-mediated pyroptosis during HIV infection. Caspase-3-mediated apoptosis accounts for the death in a small proportion of infected CD4 cells. To date, there have been no reports on the dynamics of Caspase-1 and Caspase-3 and their relationship with disease progression in acute HIV-1 infection. In this study, two distinct HIV-1 patient ...

Activation of transcription factor AP-1 in response to thermal injury in rat small intestine and IEC-6 cells

design, coordinated the study and revised the manuscript. All authors read and approved the final manuscript. Authors’ information Joint first authors: Yonghong Zhang, Hong Zhao. Acknowledgments This work

Glycerol Affects Root Development through Regulation of Multiple Pathways in Arabidopsis

Glycerol metabolism has been well studied biochemically. However, the means by which glycerol functions in plant development is not well understood. This study aimed to investigate the mechanism underlying the effects of glycerol on root development in Arabidopsis thaliana. Exogenous glycerol inhibited primary root growth and altered lateral root development in wild-type plants. ...

The Predictive Value of Waist-To-Height Ratio for Ischemic Stroke in a Population-Based Prospective Cohort Study among Mongolian Men in China

Hongmei Li 0 Mingzhi Zhang 0 Yonghong Zhang 0 Masaru Katoh, National Cancer Center, Japan 0 Department of Epidemiology, School of Public Health, Medical College of Soochow University , Suzhou , China

Associations of non-high density lipoprotein cholesterol and traditional blood lipid profiles with hyperuricemia among middle-aged and elderly Chinese people: a community-based cross-sectional study

Background Increased serum uric acid (SUA) is associated with dyslipidemia. However, there are conflicting data about the role of single lipid species including non-high density lipoprotein cholesterol (non-HDL-C) in promoting SUA accumulation. Here, we aimed to compare non-HDL-C with other traditional blood lipid profiles in relation to hyperuricemia in a middle-aged and elderly ...

Acute HIV Infection Is Beneficial for Controlling Chronic Hepatitis B

Background. Coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) is common. Most studies have concentrated on the effects of chronic HIV infection on HBV infection; however, studies on the effects of acute HIV infection on HBV infection are especially important to elucidate the potential mechanisms leading to complications from HIV/HBV coinfection. ...

Association of Biomarkers of Inflammation with Dyslipidemia and Its Components among Mongolians in China

Objective This study aims to examine the association between inflammatory biomarkers and dyslipidemia and its components among Mongolians in China. Methods Data were obtained from 2544 Mongolians via standard questionnaires and blood samples in Inner Mongolia, China. High sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble ...

Association between Human Urotensin II and Essential Hypertension—A 1:1 Matched Case-Control Study

Objective We aimed to evaluate the controversial association between human urotensin II and essential hypertension in untreated hypertensive cases and normotensive controls. Methods 197 newly diagnosed hypertensive patients and 197 age- and sex-matched normotensive controls were studied. Plasma urotensin II, nitric oxide metabolites, and other traditional biomarkers were examined. ...

An update on overweight and obesity in rural Northeast China: from lifestyle risk factors to cardiometabolic comorbidities

Background Not enough is known about the prevalence of overweight and obesity in rural China in the current decade. We aim to update our knowledge of the prevalence of obesity and its associated risk factors and comorbidities in a large population sample in rural Northeast China. Methods A population-based survey of 11,579 participants aged 35 years and older was conducted in rural ...

Association between Vitamin D Insufficiency and Elevated Serum Uric Acid among Middle-Aged and Elderly Chinese Han Women

Background Association between vitamin D insufficiency and hyperuricemia has not been reported so far. We aimed to study the association of vitamin D insufficiency with elevated serum uric acid among middle-aged and elderly Chinese Han women. Methods We collected data from participants residing in Jinchang district of Suzhou from January to May, 2010. Serum uric acid, 25-hydroxy ...