, Xiaofeng Zeng and Xiyun Yan designed the experiments. Lingling Zhang, Yongting Luo, Xiao Teng, Zhenzhen Wu and Fei Wang performed all the experiments, analyzed and interpreted the data, Mengtao Li, Dong Xu ... , Qian Wang collected patients materials, Lingling Zhang, Yongting Luo, Jing Feng, Xiaofeng Zeng and Xiyun Yan wrote the manuscript, which all authors edited and approved. Lingling Zhang, Yongting Luo
. Jianan Chen and Yongting Luo have contributed equally to this work. Electronic supplementary material The online version of this article (doi:10.1007/s13238-017-0484-5) contains supplementary material
, Hongxia Duan, Xuan Jiang, Tao Tu, Di Lu, Yongting Luo, Ping Wang, Lina Song, Jing Feng, Dongling Yang and Xiyun Yan declare that they have no conflict of interest. All institutional and national guidelines
Cell adhesion molecules (CAMs) are crucial effectors for the development and maintenance of the nervous system. Mutations in human CAM genes are linked to brain disorders and psychological diseases, and CAM knockout mice always exhibit similar behavioral abnormalities. CD146 is a CAM of the immunoglobulin superfamily that interacts with Neurite Outgrowth Factor and involved in...